Protein Alignment Nepl13 and mmel1

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: XP_017213856.1
• Gene: mmel1 / 560703
• ZFINID: ZDB-GENE-101112-2
• Length: 765
• Species: Danio rerio
• Alignment Length: 741
• Identity: 166/741 - (22%)
• Similarity: 301/741 - (40%)
• Gaps: 129/741 - (17%)

  Fly    64 MNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYS 128
            |:.|.|||.:|::||||.|   .:|.:.| |.|:...:... :.::|:.:|...|..::..:..:
Zfish    91 MDPSVDPCQNFYQYACGGW---IERHVIP-ETSSLHSVFNI-LRDELEIVLKGVLEMENKDDREA 150

  Fly   129 GASMTNVRKVRAFYESC---VAVEANASERRRFLMKILKDNGGLRNVPNSNWQ--HNRQW--VQT 186
                  .:|.:..|.||   :.:|...|:.   |:::: |:.|...|.:..|.  ..:.|  ..|
Zfish   151 ------FKKAKTLYSSCMNEILIEQRDSQP---LLRLI-DSIGDWPVASEVWNGTSEQTWSLEDT 205

  Fly   187 LGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQ 251
            |..|...|....:|.:.:..:.:......|:..:|.|         .:.:|...:.|..|:.|::
Zfish   206 LAVLNGRYNKKAVLEMFVWPDDRDSSRYIIHVDQPAL---------GMPSRDYYLSDGNYKKVRE 261

  Fly   252 QVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMG-----EQDI---QKPEEEFPPAIQAQIYG 308
            ...|     |.:.....||...::.:.|..:.:.|.     |.||   ..|.||
Zfish   262 AYLE-----FMVSMARIAREDRNLTQDEERVLEDMSQVLELETDIANATSPAEE----------- 310

  Fly   309 ARSRTGQERLRRQKGGMTLTELTSEMG-NHLDFKMLVEVIL-------ESQYPSQVYLRSPEYVK 365
                  :..:......|||.|...... |..::...::.|:       :|..|..:|. || |::
Zfish   311 ------RNDITVLYNKMTLREAQQTFNLNGFNWTRYIQGIMSSVSISVQSDEPIVIYC-SP-YLE 367

  Fly   366 HVVRTVKANNRITVGGYILYVALNEL--------------------NQPPEEAPSQRARQCVQVT 410
            .:...:..::..|:..|::::.:.:.                    ....|||   |.|.||:..
Zfish   368 KLSEVLSKHSHRTLQNYLVWMLIMDRVSSMSRRFKDVRAHYRKALHGTTVEEA---RWRDCVRYV 429

  Fly   411 QRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-----HVEWMDENDRRAARTR---L 467
            |......:|.::.|.....|:|.    :..::||.::|.:     .:.||||..:..||.:   :
Zfish   430 QGNMENAVGALYVRETFSGNSKR----MVGELIKKIQEAYVETLEELSWMDEQSKVKAREKAMAI 490

  Fly   468 SQYRVSLPDY------QSLD--LTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGL 524
            |: ::..||:      :.||  ...|.|.: |:|:..:...|...:.:..:.|| .....|...:
Zfish   491 SE-QIGYPDHILEEENKKLDQEYAHLNFSE-ENYFENILENLAASAQKGHKKLR-EPVDPDMWII 552

  Fly   525 DAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQAT 589
            .|..|.|..|..:..::...|:||.|:::....::|.:..:|..:...:...|||.|.|......
Zfish   553 GAAVVNAFYSHNRNQIVFPAGILQPPFFSEKQLQALNFGGIGMVIGHEITHGFDDHGRNFDKDGN 617

  Fly   590 AQ--WNEVTMSGYRNASECQRAQYSSYLYNEPG--EFRNATRLREIIADGSGLNLAFNAYLAWLE 650
            ..  |:..:...:.:.|:|...||..:.:...|  .....|.|.|.|||..|:..|:.||:.|:|
Zfish   618 MYNWWSNYSAERFEDQSKCMVEQYGRFSWKLAGGQNVSGITTLGENIADNGGVRQAYKAYVKWVE 682

  Fly   651 QQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLS 715
            ::..:.|       |..|:..:.||||:.|||..|.|...:.|| .::....|:|..:.|.|.|.
Zfish   683 REGEEPR-------LPGLDMNHKQLFFLNFAQVWCGACRPEYAI-QTIKTDPHSPLEYRVLGSLQ 739

  Fly   716 NSAEFGREFGCALGTPMNSGDKCLVY 741
            |...|...|.||.|.|||..:||.|:
Zfish   740 NFEAFSEAFHCARGAPMNPEEKCRVW 765

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	161/732 (22%)
mmel1	XP_017213856.1	M13	95..763	CDD:341056	162/733 (22%)