Protein Alignment Nepl13 and PHEX

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_000435.3
• Gene: PHEX / 5251
• HGNCID: 8918
• Length: 749
• Species: Homo sapiens
• Alignment Length: 746
• Identity: 167/746 - (22%)
• Similarity: 312/746 - (41%)
• Gaps: 120/746 - (16%)

  Fly    57 ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELST--AQQLMETKISEQLQQLLTQPLP 119
            |..:...:|||.|||.:||.:||..|   ......|:::.:  ....:...:..:|::||.:.:.
Human    63 AAAILSKVNLSVDPCDNFFRFACDGW---ISNNPIPEDMPSYGVYPWLRHNVDLKLKELLEKSIS 124

  Fly   120 PQHHPNGYSGASMTNVRKVRAFYESCV---AVE-ANAS------ERRRFLMKILKDNGGLRNVPN 174
            .:.....        ::|.:..|.||:   |:| |:|.      ....|...:|:.|.|    |.
Human   125 RRRDTEA--------IQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLESNIG----PE 177

  Fly   175 SNWQHNR-QWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRG 238
            ..|...: ..:|||...|..|...:.:.|.:..:.:....:.:...:..|::...|.....:|..
Human   178 GVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDYLDNSTEA 242

  Fly   239 AQVRDEVYE-LVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAI 302
            ...||.:|: :|...|.      .|.::..|......::|.|.::.      :|..|.|
Human   243 KSYRDALYKFMVDTAVL------LGANSSRAEHDMKSVLRLEIKIA------EIMIPHE------ 289

  Fly   303 QAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQ-YP--------SQVYL 358
                    :||.:....:    |.::|| |.|....|:...::.::::: ||        ..|.:
Human   290 --------NRTSEAMYNK----MNISEL-SAMIPQFDWLGYIKKVIDTRLYPHLKDISPSENVVV 341

  Fly   359 RSPEYVKHVVRTVKANNRITVGGYI----LYVALNELNQPPEEAPSQRAR-------------QC 406
            |.|:|.|.:.|.:.:..:.|:..|:    :|..:..|::..:....:.:|             :|
Human   342 RVPQYFKDLFRILGSERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKC 406

  Fly   407 VQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDV----IKALEEQFHVEWMDENDRRAA--RT 465
            |...:...|.|:|:||.....:::.|..::.:...|    |..||::  .||||...:|.|  :.
Human   407 VNFIESALPYVVGKMFVDVYFQEDKKEMMEELVEGVRWAFIDMLEKE--NEWMDAGTKRKAKEKA 469

  Fly   466 RLSQYRVSLPDY------QSLDLTDLQFQKSEDYWRRLEIALKYRSHQQF----EALRGNDFGQD 520
            |....:|..|::      .:.||..::|.:: ||:..:....||.:...|    :|:...::..:
Human   470 RAVLAKVGYPEFIMNDTHVNEDLKAIKFSEA-DYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFTN 533

  Fly   521 ADGLDAFEVRAALSPRQQMVLVGWGLLQAPYY-NYYYPKSLKYALLGHRLASALVQAFDDEG--W 582
            ...::||     .|.....:....|.||.|:: ...||:||.|..:|..:.......||:.|  :
Human   534 PTTVNAF-----YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRKY 593

  Fly   583 NNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG-EFRNATRLREIIADGSGLNLAFNAYL 646
            :.:......|:..:...::..::|...|||:|.:.:.| ..:....|.|.|||..||..||.||.
Human   594 DKNGNLDPWWSTESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAYR 658

  Fly   647 AWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVN 711
            .|:..:    |..|.:..|..:.|||.||||:.:|..|| .....:|..:.:.:..|:|.::.||
Human   659 KWINDR----RQGLEEPLLPGITFTNNQLFFLSYAHVRC-NSYRPEAAREQVQIGAHSPPQFRVN 718

  Fly   712 GPLSNSAEFGREFGCALGTPMNSG-DKCLVY 741
            |.:||..||.:.|.|...:.||.| |.|.::
Human   719 GAISNFEEFQKAFNCPPNSTMNRGMDSCRLW 749

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	162/730 (22%)
PHEX	NP_000435.3	M13	74..740	CDD:341056	158/724 (22%)