DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Nepl18

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_651643.1	Gene:	Nepl18 / 43410	FlyBaseID:	FBgn0039611	Length:	682	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	177/724 - (24%)
Similarity:	319/724 - (44%)	Gaps:	104/724 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 DSREEQLVRQKIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQ 109
            |..::.:|:.|:| :::..|.....||.||:.:|||.|.|::..||..|.::...:|:......:
  Fly    36 DYAKKIIVQAKVA-EMKTMMKPEVSPCDDFYTHACGNWHRHNPAQLLGDVMTDNFKLISKGFDRR 99

  Fly   110 LQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPN 174
            ||:||..           :.......:|::.||.||..|..:....:..|..::::.|.|..:..
  Fly   100 LQRLLRA-----------NDLQSELEKKMQRFYMSCNLVHRDDVHYKLALENVIREYGTLPALVG 153

  Fly   175 SNWQHNR-QWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRG 238
            :.|..:. .|.:|:.:::..||..|::||||..:::....|.:|..:|..        ..:.||.
  Fly   154 AQWNSSDFSWWRTVAQIQHKYGKQIIIGLEIMHDIRNTSVNRVYISQPDF--------KTINTRL 210

  Fly   239 AQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQ 303
            ..:.:||      :.:.:|:.:||:.:..|               |...|| :.:.|..|...
  Fly   211 TNLMEEV------RTSMDLQQYFGLSSSVA---------------KHTAEQ-LTELERTFSSG-- 251

  Fly   304 AQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVIL-ESQYPSQVYLRSPEYVKHV 367
                |:.:.|.||.|..    .|:.:|..:..:||:|...:.:|| |...|..:|:...||:...
  Fly   252 ----GSGAATLQESLSL----YTVADLQEKYSDHLNFTEFLGLILGEENIPKSLYIYDEEYLDKA 308

  Fly   368 VRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAK 432
            :.|:::....|...|:|:..|.:.  ..:..|....:.|.:.|::.|.::......:..:..:.:
  Fly   309 LLTMRSTPLATQANYVLWKLLEDF--LVDAQPKDMVKWCTESTKKYFGKLAEHAVYKRYRNPDVE 371

  Fly   433 HDLDAVFNDVIKALEEQ----FHVEWMDENDRRAARTRLSQYRVSLPDYQSLDLTDLQFQKSEDY 493
            .::..:: |.||.:..|    ..::|:....|..|..:|.:..:::..|..        :..|:.
  Fly   372 SEVHKIW-DQIKGIFRQRLLGDKLDWISNATRTLAIEKLERMHLNINSYDE--------ENFENV 427

  Fly   494 WRRLEI-ALKYRSH-QQFEALRGNDF----GQDADGLDAFEV---RAALSPRQQMVLVGWGLLQA 549
            :..:.| .|.|.|: ||....:|..|    .|.||.:||.|:   ..|.:.::..:.:...|||.
  Fly   428 YGEVFIDRLNYVSNVQQLLIAKGIRFVARINQPADSVDATELLGFTPAYNIQENNITIPVALLQP 492

  Fly   550 PYY-NYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQY 611
            .|: ...||::||||.||:.||..::..|||:|  ::........|:..:...:....:|.:|||
  Fly   493 RYFWGDQYPEALKYATLGYLLAHEMLHGFDDDGRQYDASGNLAPWWDLKSRYEFEERRKCFQAQY 557

  Fly   612 SSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLF 676
            ..|.|. ..:...:....|.|||..||.||:.||..||.||..:   :|.:||:..|.|.:.|||
  Fly   558 HEYQYG-GSKLPESKDQSENIADSGGLKLAYAAYELWLGQQSEE---VLQRETMEGLPFNSRQLF 618

  Fly   677 FIYFAQTRC---------WAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPM 732
            |:.:||..|         |...:.          :|.|.::.|.|||||..||...|.|:...||
  Fly   619 FLGYAQLLCDDVQFLFQPWVSQSD----------RHAPSKYRVIGPLSNFQEFPWVFNCSQSAPM 673

  Fly   733 NSGDKCLVY 741
            :...||.:|
  Fly   674 DPEYKCAIY 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	168/695 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	169/696 (24%)
Nepl18	NP_651643.1	PepO	54..682	CDD:226118	172/703 (24%)
Nepl18	NP_651643.1	M13	58..679	CDD:189000	169/696 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454940
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850