DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Nepl15

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_651098.2	Gene:	Nepl15 / 42701	FlyBaseID:	FBgn0039024	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	770	Identity:	175/770 - (22%)
Similarity:	329/770 - (42%)	Gaps:	126/770 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LGFLLELLLLFEIQLCDVTEARQNHMNRMQMSGNFPDSREEQLVRQKIATDVQKYM-NLSADPCT 72
            ||.||..:|   ..:|.: :|...|    .::.|:    ...::|...|..::.|| :.....|.
  Fly     6 LGLLLGAIL---FSICAI-DASVPH----PLAANY----SIDILRLAKAAHIKAYMGDEKEQACN 58

  Fly    73 DFFEYACGQWGRYH---KRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGASMTN 134
            :|:.|||..|.|.|   |.:.|.:.|...|:|...|.::.|:             :...||..:.
  Fly    59 NFYNYACANWPRLHPARKSKTRTNYLEELQELYIRKSADMLK-------------SATRGAENSA 110

  Fly   135 VRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNW-QHNRQWVQTLGELRRNYGLDI 198
            .|:::.||.||.....:.......|..:....||...:..::| |:...|:|.:..|:|..|:||
  Fly   111 DRQLKYFYGSCRLQTNDTRSALNTLQNVTDFRGGWPEIRVASWYQYEYDWLQVVANLKRKLGVDI 175

  Fly   199 LLGLEIDLNLQTMKGNTIYFGEPKLTIIPAE--HCNALATRGAQVRDEVYELVQQQVTENLRDWF 261
            .:|||:.|:.:..|.:.:..|.|:..:....  |.:...||      |:||   :.:...|:.:|
  Fly   176 FIGLEVILDYKEEKMHRLKIGAPQFPMSRRHYLHPHFEGTR------EIYE---RSIENKLKLYF 231

  Fly   262 GMDTGEAAR--FAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGG 324
             .:..|..|  .|..:::.|.:|.|.:...          ||:      ..::|.::|
  Fly   232 -PEQSEHWRQEVASQVVQIEQQLAKGLPHN----------PAL------TLAQTTRQR------- 272

  Fly   325 MTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALN 389
             |..|:.:..|:::|....:::|........:|....:|:.::|..::...::.:..|.::.||.
  Fly   273 -TAAEMKTAYGSYVDVTRYLQLIFNDNLYMDLYETPEDYMSNLVDVIRETPKLQLANYTMWKALE 336

  Fly   390 ELNQPPEEAPSQRAR-QCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFHVE 453
            .|:.....| ||||. .|||:.|:.||..|..:|.|:.......::|.:.::|:.:...|.....
  Fly   337 ALDIARVPA-SQRADIWCVQLAQQFFPHQLESLFHRNYNHMQMINELQSTWSDIKRVFREDLQAS 400

  Fly   454 ----WMDENDRRAARTRLSQYRVSLPDYQSLDLTDLQFQKSED----------------YWRRLE 498
                |:....|:.|.|:|...:             |.|:..:|                ::..|.
  Fly   401 ERLLWLTLETRQKAITKLEALK-------------LHFRTHDDNKLIRQMHGLILNMDRFYPNLV 452

  Fly   499 IALKYRSHQQFEALRGNDFGQD-ADGLDAFEVRAALSPRQQMVLVGWGLLQAPYY-NYYYPKSLK 561
            ..|::::.:....|......:| ...|..:|:      ::..:.|....|||.:: :..||..||
  Fly   453 SVLQWKTQRGLAKLMTEPVAEDEVHKLPHYEI------QKNRIQVPITFLQARFFWDPAYPNGLK 511

  Fly   562 YALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRN 624
            ||.||..||..::..||..|  ::.:......|:..:.|.|...::|.:.||:.::..:....::
  Fly   512 YATLGVLLARQMLHGFDGVGRRYDAYGYKNNWWDHTSESSYSRRTQCFQEQYAIFVEYKGKPVQD 576

  Fly   625 ATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLL-AKETLSELNFTNTQLFFIYFAQTRCWAK 688
            ...||.|:||...|::|:.||..||:....  .|:: .:|.|..|:..:.|:|::.:||..|  .
  Fly   577 KDLLRRIVADNGALDIAYRAYQQWLKNAAE--TPVIYQRERLPLLDHDHNQIFYLGYAQLYC--T 637

  Fly   689 DNQDAI--LDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            |..:.:  .|.:      ||:..||..||||.:|...:||:....:|:..||.:|
  Fly   638 DYPETVERFDEL------PEQLRVNTALSNSQQFANAYGCSREEKLNARFKCTLY 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	160/705 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	159/705 (23%)
Nepl15	NP_651098.2	M13	57..684	CDD:189000	160/703 (23%)
Nepl15	NP_651098.2	PepO	57..677	CDD:226118	158/696 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454937
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	1	1.000	-	-		FOG0007609
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.850