DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Nep2

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001246914.1	Gene:	Nep2 / 40588	FlyBaseID:	FBgn0027570	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	170/820 - (20%)
Similarity:	303/820 - (36%)	Gaps:	239/820 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 GNFPDSREEQLVRQKI--ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDE---LSTAQQ 100
            |...||.:..|.::.|  |:.|.:.|....:||.:|:|:||   |.|.:.:..||:   :||. .
  Fly    75 GKSGDSGDVCLTQECIHTASTVLRKMKPEVEPCDNFYEFAC---GTYLEEENIPDDKVSISTF-S 135

  Fly   101 LMETKISEQLQQLLTQPLP---PQHH--PNGYSGASMTNVRKVRAFYESCV---AVEANASERRR 157
            ::..|:.|||:.::|...|   |:|.  ||              ..|::|:   .:|....|.
  Fly   136 VISDKLQEQLKDIITAERPETEPKHFRLPN--------------LLYKACMNKTLIETLGPEP-- 184

  Fly   158 FLMKILKDNGGLRNVPNSNWQHNRQWV--------QTLGELRRNYGLDILLGLEIDLNLQTMKGN 214
             :.::.:..||...:...:|..:..|.        :|.|     :.:|.::...|.::||.....
  Fly   185 -ITRVAERLGGWPLIKGDSWNADDSWTWQEQVKKFRTAG-----FSMDYIIDFSIGVDLQNSTKR 243

  Fly   215 TIYFGEPKLTIIPAEHCNALATRGAQVR--DEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIR 277
            .|...:..|.:          :|...|:  :|.......:...::...||.:...|....  ::.
  Fly   244 LIDLDQSSLAL----------SREYLVKGFNETLVTAYYKYMVDIAVLFGANRDLAKTEL--LLS 296

  Fly   278 FEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKM 342
            .|||    |...:|..|.|:                     ||.         :||:     :.:
  Fly   297 LEFE----MALANISWPNEK---------------------RRN---------SSEL-----YNL 322

  Fly   343 LVEVILESQYP---------------------SQVYLRSPEYVKHVVRTVKANNRITVGGYILY- 385
            .....|::.||                     ..:.|..|.:.:.:.:.:....:..:..|:.:
  Fly   323 RTPAQLQAAYPYVQWVDYMNALLPEGLNVAEDEMINLSVPSFFEDLGKLLAKTPKRVIANYMFWR 387

  Fly   386 ---------------------VALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQ------ 423
                                 .||:  .:..:||   |.::||.:......:|..:.|.
  Fly   388 IHGFSVGFLSEEFRKRQLQYATALS--GRQEQEA---RWKECVDIATSSMDEVCEDDFDSLGISV 447

  Fly   424 ------RHVQRDNAKHDLDA------VFNDVIKALEEQFHVEWMDENDRRAARTRLSQY--RVSL 474
                  :|..:|:..:.|:.      ||||:   |:|   |.|||...::.|:.:|...  .:..
  Fly   448 GSLYVGKHFHKDSKANALEMVNEIRNVFNDI---LDE---VNWMDAKTKKEAKLKLHSMATHIGY 506

  Fly   475 PDYQSLDLTDLQFQKSEDYWRRLEI-ALKYRSHQQFEALRG-NDFGQDADGLDAFE--------- 528
            ||..      |..:|...|:.:|:| ..||     ||:..| |.||.|.    :|.
  Fly   507 PDEM------LDNEKLAAYYAKLDIDPDKY-----FESFLGMNIFGTDY----SFNKLRLPVNKT 556

  Fly   529 ----------VRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG-- 581
                      |.|..|..:..:....|:||..::|...||.:.:..:|:.:...:...|||:|
  Fly   557 DWVRHARPAIVNAFYSSLENSIQFPAGILQGHFFNAQRPKYMNFGAIGYVIGHEITHGFDDQGRQ 621

  Fly   582 ---------WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNATRLR-EIIADGS 636
                     |         |:..|...|...::|...||.:|.....|...|....: |.|||..
  Fly   622 FDVKGNLRDW---------WHPDTQKAYLAKAKCIIEQYGNYTERATGLNLNGINTQGENIADNG 677

  Fly   637 GLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLM 701
            |:..::.||..|.|:...:.:       |..|::|..|:|::...||.| ||..::::...:...
  Fly   678 GVKESYIAYRRWAEKHGPEAK-------LPGLDYTPEQMFWVAAGQTWC-AKYRKESLKMRITTG 734

  Fly   702 QHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|:|..:.|.|.|||..:|.::|.|..|:|||...||.|:
  Fly   735 VHSPSEFRVLGSLSNMKDFAKDFHCPEGSPMNPVQKCEVW 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	157/785 (20%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	159/786 (20%)
Nep2	NP_001246914.1	M13	104..772	CDD:189000	160/787 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.920