Protein Alignment Nepl13 and phex

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001307259.2
• Gene: phex / 386969
• ZFINID: ZDB-GENE-030103-2
• Length: 745
• Species: Danio rerio
• Alignment Length: 755
• Identity: 173/755 - (22%)
• Similarity: 308/755 - (40%)
• Gaps: 140/755 - (18%)

  Fly    57 ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELST--AQQLMETKISEQLQQLLTQPLP 119
            |..:...|:.|.|||.||::||||.|.|.:.   .|::.|:  ....:...:..:|::||.||:
Zfish    61 AGSILSKMDQSVDPCDDFYQYACGGWLRENP---IPEDSSSYGIYPWLRQNVDLKLKELLEQPV- 121

  Fly   120 PQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQWV 184
                    ....:..|:|.:..|.||:...|...|....|:|.||.......|.......:.:||
Zfish   122 --------RSGDIEAVKKAKVLYASCMNESALEIEDANPLLKNLKQKEFRWPVLGDALGSSSRWV 178

  Fly   185 -------QTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVR 242
                   :||.::|..:...:|:                     :|.:.|.:         ....
Zfish   179 ESQFNLLETLAQIRSQHSKSVLI---------------------RLFVAPDD---------KNSN 213

  Fly   243 DEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIY 307
            ..:.:|.|..::.:.|:.:..:|.||..:...::|...::...:|..: |..|.:....:..::.
Zfish   214 QYIIKLDQASLSLSSREDYITNTTEAQMYREALLRLMVDVSVMLGASE-QAAEAQMKSVLDFEMK 277

  Fly   308 GAR------SRTGQERLRRQKGGMTLTELTSEMGNHLDFKML--VEVILESQ-YP-------SQV 356
            .|:      :||.:....:    .:|::|...:.   ||..|  |..::::: ||       .||
Zfish   278 LAQIVIPYENRTSENMYNK----YSLSKLQRTVP---DFNWLGFVRAVIDTELYPDLKISSSEQV 335

  Fly   357 YLRSPEYVKHVVRTVKANNRITVGGYILY-----------------------VALNELNQPPEEA 398
            .:|:|:|.|.:.:.:.|.:..||..|:::                       |.....:..|
Zfish   336 IVRAPQYFKDLFKLINATDTRTVANYVIWRSVFSRITTLSRRFLYRYLDFARVTTGTTSLTP--- 397

  Fly   399 PSQRARQCVQVTQRLFPQVLGEMF-QRHVQRDNAKHDLDAVFNDV----IKALEEQFHVEWMDEN 458
               |..:||...:.......|.:| .:|.|.|. ||.::.:.|.:    |..||::  .|||||.
Zfish   398 ---RWDKCVNYVENTLIYAAGRLFVDKHFQEDK-KHMMEELINGIRWAFIDILEKE--NEWMDEE 456

  Fly   459 DRRAA--RTRLSQYRVSLPD------YQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGN 515
            .:|.|  :......:|..||      |.:.|:..|.|..: ||:..:...||:.:......||
Zfish   457 TKRKAIDKAHAVLPKVGYPDFILNDTYINEDIKRLAFTMT-DYFGNVMQTLKFIAQSDIGWLR-- 518

  Fly   516 DFGQDADGLDAF----EVRAALSPRQQMVLVGWGLLQAPYY-NYYYPKSLKYALLGHRLASALVQ 575
               :.....:.|    .|.|..|.....:....|.||.|:: ...||:||.|..:|..:...|..
Zfish   519 ---KTVPRTEWFTNPTTVNAFYSSSTNQIRFPAGELQKPFFWGLNYPRSLSYGAIGVIVGHELTH 580

  Fly   576 AFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG-EFRNATRLREIIADGSG 637
            .||:.|  ::........|:..:::.:...::|...||:||.:.|.| ..:....|.|.|||..|
Zfish   581 GFDNNGRKYDKDGNLDQWWSNSSINRFTEKTQCMIDQYNSYYWKEAGLNVKGKRTLAENIADNGG 645

  Fly   638 LNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQ 702
            :..:|.||..|:|::    |..:.:..|..:..|:.||||:.:|..||.|. ..:|..|.:....
Zfish   646 IRESFRAYRRWVEKE----RGGVEEPLLPGVGLTHNQLFFLSYAHVRCNAY-RPEAARDQIQSGA 705

  Fly   703 HTPERWDVNGPLSNSAEFGREFGCALGTPMNSG-DKCLVY 741
            |:|.::.|.|.:||..||.:.|.|...:.||.| :.|.|:
Zfish   706 HSPPKYRVIGAMSNFEEFRKAFNCPETSIMNRGTESCRVW 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	168/739 (23%)
phex	NP_001307259.2	None