DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and KEL

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_005250050.1	Gene:	KEL / 3792	HGNCID:	6308	Length:	744	Species:	Homo sapiens

Alignment Length:	803	Identity:	173/803 - (21%)
Similarity:	296/803 - (36%)	Gaps:	195/803 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LGFLL--ELLLLFEIQLCDVTEARQNHMNRMQMSGNFP-------DSREEQLVRQKIATDVQKYM 64
            ||.||  .:||.:..|.|                |..|       |.|:..|...
Human    67 LGLLLCFSVLLFYNFQNC----------------GPRPCETSVCLDLRDHYLASG---------- 105

  Fly    65 NLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYSG 129
            |.|..||||||.:|||          |..|.:.:.|.:.||...:|:::|  .:....||.  ||
Human   106 NTSVAPCTDFFSFACG----------RAKETNNSFQELATKNKNRLRRIL--EVQNSWHPG--SG 156

  Fly   130 ASMTNVRKVRAFYESC---VAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQWV-----QT 186
            .     .|...||.||   :|:||..:..   |.:::::.||        |:.:.:|.     :|
Human   157 E-----EKAFQFYNSCMDTLAIEAAGTGP---LRQVIEELGG--------WRISGKWTSLNFNRT 205

  Fly   187 LGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQ 251
            |..|...||                     :|  |........|..:..|...|:....:::..:
Human   206 LRLLMSQYG---------------------HF--PFFRAYLGPHPASPHTPVIQIDQPEFDVPLK 247

  Fly   252 QVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGE---QDIQKPEE--EFPPAIQAQIYGARS 311
            |..|.             :....|.|.......|:|.   .|..|.:|  ....:|.::::....
Human   248 QDQEQ-------------KIYAQIFREYLTYLNQLGTLLGGDPSKVQEHSSLSISITSRLFQFLR 299

  Fly   312 RTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILE--SQYPSQ-VYLRSPEYVKHVVRTVK- 372
            ...|.|.:.:...|...:...||...:|:...::....  |..||| :.:...||:|::.:.|:
Human   300 PLEQRRAQGKLFQMVTIDQLKEMAPAIDWLSCLQATFTPMSLSPSQSLVVHDVEYLKNMSQLVEE 364

  Fly   373 --------ANNRITVGGYI----------------LYVALNELNQPPEEAPSQRARQCVQVTQRL 413
                    ..:.:.:|..:                |...|.||.:.|......|..:||:.|...
Human   365 MLLKQRDFLQSHMILGLVVTLSPALDSQFQEARRKLSQKLRELTEQPPMPARPRWMKCVEETGTF 429

  Fly   414 FPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-HVEWMDENDRRAARTRLSQYRVSL--- 474
            |...|..:|.|.....:.:.....:|..:..||..:. ::.||:|..:..|:.:::|.:|.:
Human   430 FEPTLAALFVREAFGPSTRSAAMKLFTAIRDALITRLRNLPWMNEETQNMAQDKVAQLQVEMGAS 494

  Fly   475 -----PDYQSLDLTDLQ----FQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVR 530
                 |:....:..|:|    |.:|.....|   :|:.|..|.|  |:.:.  |....:..::|.
Human   495 EWALKPELARQEYNDIQLGSSFLQSVLSCVR---SLRARIVQSF--LQPHP--QHRWKVSPWDVN 552

  Fly   531 AALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDD-------EGWNNHPQA 588
            |..|....:|:...||||.|:::..||:::.:...|..:|..|:..|..       ...:||
Human   553 AYYSVSDHVVVFPAGLLQPPFFHPGYPRAVNFGAAGSIMAHELLHIFYQLLLPGGCLACDNH--- 614

  Fly   589 TAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQD 653
                      ..:.|..|.:..|:::.......|.::....|..||..||.:|..||       .
Human   615 ----------ALQEAHLCLKRHYAAFPLPSRTSFNDSLTFLENAADVGGLAIALQAY-------S 662

  Fly   654 HKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSA 718
            .:|.....:..|..|:.:..|:||..:||..|.....||: .|:     |:|....|:||||::.
Human   663 KRLLRHHGETVLPSLDLSPQQIFFRSYAQVMCRKPSPQDS-HDT-----HSPPHLRVHGPLSSTP 721

  Fly   719 EFGREFGCALGTPMNSGDKCLVY 741
            .|.|.|.||.|..:|...:|.::
Human   722 AFARYFRCARGALLNPSSRCQLW 744

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	158/729 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	157/730 (22%)
KEL	XP_005250050.1	PepO	106..744	CDD:226118	160/736 (22%)
KEL	XP_005250050.1	M13	109..742	CDD:189000	157/731 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810