DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Nepl5

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_609022.1	Gene:	Nepl5 / 33892	FlyBaseID:	FBgn0031808	Length:	684	Species:	Drosophila melanogaster

Alignment Length:	801	Identity:	171/801 - (21%)
Similarity:	301/801 - (37%)	Gaps:	190/801 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 AWLGFLLELLLLFEIQLCDVTEARQNHMNRMQMSGNFPDSREEQLVRQKIATDVQKYMNLSADPC 71
            |||.|.|       ......|..||.         |.|.|.:|.|..|     :|.||:..|.||
  Fly     8 AWLIFSL-------AWRTTPTACRQT---------NAPQSVQEMLAEQ-----LQSYMDTKARPC 51

  Fly    72 TDFFEYACGQW-------------------GRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQP 117
            .:|::||||.|                   .||..:.|..|.|.    |::..::.:|:.||.:
  Fly    52 ENFYQYACGNWQIQQQEQHSLRDRDWTRDRQRYQGQMLPTDTLG----LIDHSVNRKLELLLRR- 111

  Fly   118 LPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNR- 181
               ::..:..|.:|:  :.::|.:|.||..::  ....:::|..:...|..........|:..|
  Fly   112 ---RNESSFESDSSI--LEQMRLYYRSCKRLK--PYNLKKYLQLLPPSNSTQWPSVGRGWRPERF 169

  Fly   182 QWVQTLGELRRNYGLD-ILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEV 245
            .|:.|||.||. :||: :||..|:.......:..:||..:|.                   |.|.
  Fly   170 DWITTLGRLRL-HGLNGVLLREEVLPRWDDSRNYSIYVNKPS-------------------RQET 214

  Fly   246 YELVQQQVTENLRDWFGMDTGEAARFAGDIIR----FEFELCKQMGEQDIQKPEEEFPPAIQAQI 306
            ..:.:..:.|.|     :|.|:..|.|..:.|    ||.:|.:....:|.:.|.|
  Fly   215 QPMGEGAMIELL-----LDIGQTKRTANALARQVDDFERKLHRLQELEDDEGPRE---------- 264

  Fly   307 YGARSRTGQERLRRQKGGMTLTELTSEMG--NHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVR 369
                              |.|..|.|.:.  ..|.|...|.:..|....|.:.:.:..|::.:..
  Fly   265 ------------------MQLGYLDSYLPQLRWLSFMRQVRIDSELDLRSTLIIENIPYLRALSD 311

  Fly   370 TVKANNRITVGGYILYVALNELNQPPEEAPSQRAR-QCVQVTQRLFP----QVLGEMFQRHVQRD 429
            .:::.:..||..||:...|..|.|   :.|:..:| :||...:|..|    .::|:.|.
  Fly   312 LMESESPDTVCSYIMLKWLAFLKQ---QGPADISRGECVAALRRAMPLASSWLVGQQFS------ 367

  Fly   430 NAKHDLDAVFNDVIKALEEQFHVEW---MDENDRRAA-------RTRLSQYRVSLPDYQSLDLTD 484
                  |......:.:|.::..|.:   :.||..|.:       :.:|...|:.:..:|:.::.|
  Fly   368 ------DPESESYVSSLFQRLKVRFGQILAENRMRLSPPLVHILQQKLRAVRLQMGFFQTEEIED 426

  Fly   485 LQFQKSEDYWRRLEIA---------------------LKYRSHQQFEALRGNDFGQDADGLDAFE 528
            :     |.|..|::::                     |.|.:...|....|::....::..:|..
  Fly   427 V-----EQYHVRIDLSGHSFYGNQLVLLRQRVEANHDLLYINVTNFANSTGSNLSYLSESWEASN 486

  Fly   529 VRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQATAQW- 592
            ........:.:|||..||||.|.::.......::|::|..||..|...||..|.:.........
  Fly   487 SSPLYVRPRNLVLVPHGLLQLPIWHRNISALQQHAVMGFVLAHELAHGFDMLGMDYDAMGNIMGP 551

  Fly   593 -NEVTMS-GYRNASECQRAQYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHK 655
             .|:..| .:|...:|.:.|.::          .:..:.|.:||...|.||:..:....::::.:
  Fly   552 VEEIGASRQFRQGLQCLQQQMAT----------GSKWIDEKLADFVALRLAYETFFGVRDKREPR 606

  Fly   656 LRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEF 720
             .|||.:       |:..|||||.|||..|...........|...::|..:...|...|:|..||
  Fly   607 -DPLLPQ-------FSQRQLFFITFAQFFCGRTPVLSPRSQSEAHLKHAADELRVMQTLANFEEF 663

  Fly   721 GREFGCALGTPMNSGDKCLVY 741
            .|||||.....|.:..:|.::
  Fly   664 SREFGCDKKAKMQASQRCRIW 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	154/734 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	153/735 (21%)
Nepl5	NP_609022.1	PepO	42..684	CDD:226118	156/744 (21%)
Nepl5	NP_609022.1	GluZincin	48..682	CDD:301352	153/736 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850