DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and frma

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_572226.2	Gene:	frma / 31464	FlyBaseID:	FBgn0029769	Length:	611	Species:	Drosophila melanogaster

Alignment Length:	736	Identity:	158/736 - (21%)
Similarity:	265/736 - (36%)	Gaps:	195/736 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 VQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHP 124
            ||...:..||||.:|::.|||.|...|    ..|...:....::....|:|..||         .
  Fly    17 VQVKSHPQADPCQNFYKVACGNWSASH----ATDSYESFMDRLDYNYQEKLADLL---------D 68

  Fly   125 NGYSGASMTNVRKVRAFYESCVAVEANASERRRF----LMKILKDNGGLRNVPNSNWQHNRQWVQ 185
            |.........::::|.||.:|         |:..    :::||:....:.|:.|.
  Fly    69 NEREDDEPHFLQQLRNFYTAC---------RKPLSQDQVLRILEHLIVMENIQNE---------- 114

  Fly   186 TLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQ 250
               ||  :.||.....|::.::|.......|:    |..:...:|.:...|....:..|:::.:
  Fly   115 ---EL--SVGLTAAFRLQVLIDLNDSNTYDIW----KQLMSHRKHWDPNTTNREPLTREMFDKL- 169

  Fly   251 QQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGAR----- 310
                     |..:..          |.|.|   |:...:::.:.||:.      ..||:.
  Fly   170 ---------WASLPK----------IPFPF---KEYYWRELSELEEKI------MSYGSEDDGFD 206

  Fly   311 -----SRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVRT 370
                 :|.....:.....|....|..|:|.:.||.| ..|.||     :.:|:|    :|.|...
  Fly   207 SGDLVTRIPPFWMMPWPNGNITYENLSQMAHWLDIK-ANEFIL-----TYIYMR----LKLVAEG 261

  Fly   371 VKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDL 435
            |..                       |:......||.:.::    |:|.......|::::.:...
  Fly   262 VST-----------------------ESWHIDRDQCAEQSR----QILSHPAAWLVEKNHPRLKE 299

  Fly   436 DAVFNDVIKALEEQFHVEWMDENDRRAART------RLSQYRVSL------PDYQSL------DL 482
            :.|..|:...|:::|..:.:...:.....|      :|.:.|:.|      ...||:      ..
  Fly   300 EPVLQDIFAELKQRFGQKLLANRNNFTRSTQHFLLGKLKRMRLRLSILPRNSSAQSMVRRIERHY 364

  Fly   483 TDLQFQKSEDYWRRLEIALKY-RSHQQFEALRGNDFGQ-------DADGLDAFEVR-------AA 532
            .|:....| ||:..|.|.|.: |||:::..|....||:       ....|...:||       |.
  Fly   365 RDVHMNAS-DYFGNLHIGLNHSRSHKKYAQLWAIVFGRQLIPSRISKSDLYPTQVRGYGTYASAF 428

  Fly   533 LSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEV 595
            ...:|.|::|...||:.|:|.:..|..|.|:.||..|...|...||.||  :::|...::..:..
  Fly   429 YIVKQNMLIVPLSLLEPPFYTHGQPSILTYSALGFILGHELSHGFDSEGMTFSSHGVGSSAVDRE 493

  Fly   596 TMSGYRNASE--CQRAQYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRP 658
            .....|...|  |.|.::....|             |..||.|||.||::||.. ..|.||| |.
  Fly   494 LDRNPRFQQELGCLRRRFGRKRY-------------EKFADASGLELAYSAYFD-TAQTDHK-RN 543

  Fly   659 LLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQ---HTPERWDVNGPLSNSAEF 720
            ..|:|.:     |..|.||..|||..|..|:          |:|   |..:|..||..:::...|
  Fly   544 RSAEELV-----TQKQQFFHNFAQFFCSDKE----------LLQAHDHGSDRKRVNDAVAHFEPF 593

  Fly   721 GREFGCALGTPMNSGDKCLVY 741
            ...|.|.   |.....:|.:|
  Fly   594 REAFSCG---PSPRRRQCRLY 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	153/722 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	154/723 (21%)
frma	NP_572226.2	GluZincin	25..601	CDD:301352	153/716 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940