DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Mmel1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001101467.2	Gene:	Mmel1 / 313755	RGDID:	1309299	Length:	774	Species:	Rattus norvegicus

Alignment Length:	781	Identity:	183/781 - (23%)
Similarity:	317/781 - (40%)	Gaps:	155/781 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SREEQLVRQKIATD-------------------VQKYMNLSADPCTDFFEYACGQWGRYHKRQLR 91
            ||.|:.|.:::..|                   :.:.|:.|..||.:|::||||.|.|:|   :.
  Rat    64 SRHERTVVKRVLRDSSQKSDICTTPSCVIAAARILQNMDQSKKPCDNFYQYACGGWLRHH---VI 125

  Fly    92 PDELSTAQQLMETKISEQLQQLLTQPLPP---QHHPNGYSGASMTNVRKVRAFYESCV---AVEA 150
            | |.::...:.:. :.::|:.:|...|..   ||.|         .|.|.:..|.||:   .:|.
  Rat   126 P-ETNSRYSVFDI-LRDELEVILKGVLEDSSVQHRP---------AVEKAKTLYRSCMNQSVIEK 179

  Fly   151 NASERRRFLMKILKDNGG-------LRNVPNSNWQHNRQWVQTLGELRRNYGLDILLGLEIDLNL 208
            ..||.   |:.:|...||       ........|:..||    |..|...:...:|:.|.|..:.
  Rat   180 RDSEP---LLNVLDMIGGWPVAMDKWNETMGPKWELERQ----LAVLNSQFNRRVLIDLFIWNDD 237

  Fly   209 QTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAG 273
            |....:.||..:|              |.|...|:..::....:|.|....:.   |..|.....
  Rat   238 QNSSRHVIYIDQP--------------TLGMPSREYYFKEDSHRVREAYLQFM---TSVATMLRR 285

  Fly   274 DIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQER------LRRQKGGMTLTELTS 332
            |:        ...||.|:  .:||....:..:.:.|.:...||:      |..:.|   |.||..
  Rat   286 DL--------NLPGETDL--VQEEMAQVLHLETHLANATVPQEKRHDVTALYHRMG---LEELQE 337

  Fly   333 EMG-NHLDFKMLVEVILESQYPSQVYLRSPE--------YVKHVVRTVKANNRITVGGYILY--- 385
            ..| ...::.:.::.:|.|   .||.|...|        |::::...:......|:..|:::
  Rat   338 RFGLKGFNWTLFIQNVLSS---VQVELLPNEEVVVYGIPYLENLEEIIDVFPAQTLQNYLVWRLV 399

  Fly   386 -VALNELNQPPEEA-------------PSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLD 436
             ..:..|:|..:||             ...|.|:||..........:|.::   ::|..:| |..
  Rat   400 LDRIGSLSQRFKEARVDYRKALYGTTMEEVRWRECVSYVNSNMESAVGSLY---IKRAFSK-DSK 460

  Fly   437 AVFNDVIKALEEQF-----HVEWMDENDRRAARTRLSQYR--VSLPDY------QSLD--LTDLQ 486
            ::.:::|:.:...|     .:.||||..::.|:.:....|  :..|||      :.||  .:.|.
  Rat   461 SIVSELIEKIRSVFVDNLDELNWMDEESKKKAQEKALNIREQIGYPDYILEDNNRHLDEEYSSLT 525

  Fly   487 FQKSED-YWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAP 550
            |  ||| |:......||..:.:..:.|| ....|:...:.|..|.|..||.:.:::...|:||.|
  Rat   526 F--SEDLYFENGLQNLKNNAQRSLKKLR-EKVDQNLWIIGAAVVNAFYSPNRNLIVFPAGILQPP 587

  Fly   551 YYNYYYPKSLKYALLGHRLASALVQAFDDEGWN--NHPQATAQWNEVTMSGYRNASECQRAQYSS 613
            :::...|::|.:..:|..:...:...|||.|.|  .:......|:..:...:|..|:|...|||:
  Rat   588 FFSKDQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMLDWWSNFSARHFRQQSQCMIYQYSN 652

  Fly   614 YLYNEPGEFRNA---TRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQL 675
            :.: |..:.:|.   :.|.|.|||..|:..|:.|||.||.:.....|       |..||.|..||
  Rat   653 FSW-ELADNQNVNGFSTLGENIADNGGVRQAYKAYLQWLAEGGRDQR-------LPGLNLTYAQL 709

  Fly   676 FFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLV 740
            |||.:||..|.:...:.|| .|:....|:|.::.|.|.|.|...|...|.|..|:||:..::|.:
  Rat   710 FFINYAQVWCGSYRPEFAI-QSIKTDVHSPLKYRVLGSLQNLPGFSEAFHCPRGSPMHPMNRCRI 773

  Fly   741 Y 741
            :
  Rat   774 W 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	175/734 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	175/735 (24%)
Mmel1	NP_001101467.2	Stop-transfer sequence. /evidence=ECO:0000255	14..21
Mmel1	NP_001101467.2	M13	106..772	CDD:341056	175/735 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920