Protein Alignment Nepl13 and Mmel1

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_038811.2
• Gene: Mmel1 / 27390
• MGIID: 1351603
• Length: 766
• Species: Mus musculus
• Alignment Length: 750
• Identity: 172/750 - (22%)
• Similarity: 304/750 - (40%)
• Gaps: 133/750 - (17%)

  Fly    57 ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPL--- 118
            |..:.:.|:.|.:||.:|::||||.|.|:|   :.| |.::...:.:. :.::|:.:|...|
Mouse    85 AARILENMDQSRNPCENFYQYACGGWLRHH---VIP-ETNSRYSVFDI-LRDELEVILKGVLEDS 144

  Fly   119 PPQHHPNGYSGASMTNVRKVRAFYESCV---AVEANASERRRFLMKILKDNGG-------LRNVP 173
            ..||.|         .|.|.:..|.||:   .:|...||.   |:.:||..||       .....
Mouse   145 TSQHRP---------AVEKAKTLYRSCMNQSVIEKRDSEP---LLSVLKMVGGWPVAMDKWNETM 197

  Fly   174 NSNWQHNRQWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRG 238
            ...|:..||    |..|...:...:|:.|.|..:.|....:.||..:|.|. :|:..........
Mouse   198 GLKWELERQ----LAVLNSQFNRRVLIDLFIWNDDQNSSRHVIYIDQPTLG-MPSREYYFQEDNN 257

  Fly   239 AQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQ 303
            .:||....|.:....|                    ::|.:..|.|:..     ...||....::
Mouse   258 HKVRKAYLEFMTSVAT--------------------MLRKDQNLSKESA-----MVREEMAEVLE 297

  Fly   304 AQIYGARSRTGQER---LRRQKGGMTLTELTSEMG-NHLDFKMLVEVILES----QYP-SQVYLR 359
            .:.:.|.:...||:   :......|.|.||....| ...::.:.::.:|.|    .:| .:|.:.
Mouse   298 LETHLANATVPQEKRHDVTALYHRMDLMELQERFGLKGFNWTLFIQNVLSSVEVELFPDEEVVVY 362

  Fly   360 SPEYVKHVVRTVKANNRITVGGYILY----VALNELNQPPEEA-------------PSQRARQCV 407
            ...|::::...:.:.:..|:..|:::    ..:..|:|..:||             ...|.|:||
Mouse   363 GIPYLENLEDIIDSYSARTMQNYLVWRLVLDRIGSLSQRFKEARVDYRKALYGTTVEEVRWRECV 427

  Fly   408 QVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-----HVEWMDENDRRAARTRL 467
            ..........:|.::   ::|..:| |..:...::|:.:...|     .:.||||..::.|:.:.
Mouse   428 SYVNSNMESAVGSLY---IKRAFSK-DSKSTVRELIEKIRSVFVDNLDELNWMDEESKKKAQEKA 488

  Fly   468 SQYR--VSLPDY------QSLD-----LT---DLQFQKSEDYWRRLEIALKYRSHQQFEALRGND 516
            ...|  :..|||      :.||     ||   ||.|:....       .||..:.:..:.|| ..
Mouse   489 MNIREQIGYPDYILEDNNKHLDEEYSSLTFYEDLYFENGLQ-------NLKNNAQRSLKKLR-EK 545

  Fly   517 FGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG 581
            ..|:...:.|..|.|..||.:..::...|:||.|:::...|:||.:..:|..:...:...|||.|
Mouse   546 VDQNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKDQPQSLNFGGIGMVIGHEITHGFDDNG 610

  Fly   582 WN--NHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNA---TRLREIIADGSGLNLA 641
            .|  .:......|:..:...::..|:|...||.::.: |..:.:|.   :.|.|.|||..|:..|
Mouse   611 RNFDKNGNMLDWWSNFSARHFQQQSQCMIYQYGNFSW-ELADNQNVNGFSTLGENIADNGGVRQA 674

  Fly   642 FNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPE 706
            :.|||.||.......|       |..||.|..|||||.:||..|.:...:.|: .|:....|:|.
Mouse   675 YKAYLRWLADGGKDQR-------LPGLNLTYAQLFFINYAQVWCGSYRPEFAV-QSIKTDVHSPL 731

  Fly   707 RWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            ::.|.|.|.|...|...|.|..|:||:...:|.::
Mouse   732 KYRVLGSLQNLPGFSEAFHCPRGSPMHPMKRCRIW 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	168/734 (23%)
Mmel1	NP_038811.2	M13	97..764	CDD:341056	168/734 (23%)