Protein Alignment Nepl13 and Ece1

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001356106.1
• Gene: Ece1 / 230857
• MGIID: 1101357
• Length: 769
• Species: Mus musculus
• Alignment Length: 747
• Identity: 182/747 - (24%)
• Similarity: 303/747 - (40%)
• Gaps: 144/747 - (19%)

  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELS---TAQQLMETKISEQLQQLLTQP 117
            :.:.:...|:.:.|||.|||.||||.|   .|....||..|   |...|.|.. ...::.||..
Mouse   106 VTSSILNSMDPTVDPCQDFFSYACGGW---IKANPVPDGHSRWGTFSNLWEHN-QAVIKHLLEN- 165

  Fly   118 LPPQHHPNGYSGASMTNV-RKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNR 181
                      :.||::.. ||.:.:|.:|:........|.:.||::::..||        |....
Mouse   166 ----------ATASVSEAERKAQVYYRACMNETRIEELRAKPLMELIEKLGG--------WNITG 212

  Fly   182 QWVQ-----TLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQV 241
            .|.:     ||..:..:|.......:.:..:.:....|.|...:..|              |...
Mouse   213 PWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGL--------------GLPS 263

  Fly   242 RDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQM--GEQDIQKPEE----EFPP 300
            ||  |.|   ..|||.:...|            .:.:..:|.|.:  |::|..:|:.    :|..
Mouse   264 RD--YYL---NKTENEKVLTG------------YLNYMVQLGKLLGGGDEDAIRPQMQQILDFET 311

  Fly   301 AIQAQIYGARSRTGQERLRRQKGGMTLTEL--TSEMGNHLDFKMLVEVILESQYPSQVYLRSPEY 363
            |: |.|...:.:...|.|...|  :|..||  .:...|.|.|...:...:|......:.:...||
Mouse   312 AL-ANITIPQEKRRDEELIYHK--VTAAELQTLAPAINWLPFLNTIFYPVEINESEPIVVYDKEY 373

  Fly   364 VKHVVRTVKANNRITVGGYILYVALNE----LNQPPEEAPSQ--------------RARQCVQVT 410
            ::.|...:...::..:..|:::..:.:    |:|..::|..:              |.:.||..|
Mouse   374 LRQVSTLINNTDKCLLNNYMMWNLVRKTSSFLDQRFQDADEKFMEVMYGTKKTCIPRWKFCVSDT 438

  Fly   411 QRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMDENDRRAARTR------LS 468
            :......||.||.:....:::|:....:..::.||.||... ::||||..||:|:.:      :.
Mouse   439 ENNLGFALGPMFVKATFAEDSKNIASEIIMEIKKAFEESLSTLKWMDEETRRSAKEKADAIYNMI 503

  Fly   469 QYRVSLPDYQSLD--------LTDLQFQKSEDY----WRRLEIALKYRSHQQFEALRGNDFGQDA 521
            .|...:.|.:.||        :.||.|:.:..:    ||.....|:...:            :|.
Mouse   504 GYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRKAPN------------RDQ 556

  Fly   522 DGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNN 584
            ..:....|.|..||.:..::...|:||||:|....|.:|.:..:|..:...|..||||:|  ::.
Mouse   557 WSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPNALNFGGIGVVVGHELTHAFDDQGREYDK 621

  Fly   585 HPQATAQWNEVTMSGYRNASECQRAQYSSYLYN-EPGEFRNATRLREIIADGSGLNLAFNAYLAW 648
            .......|...::..::..:||...|||:|..| ||...|:.  |.|.|||..||..|:.||..|
Mouse   622 DGNLRPWWKNSSVEAFKQQTECMVQQYSNYSVNGEPVNGRHT--LGENIADNGGLKAAYRAYQNW 684

  Fly   649 LEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQDAILDSMPLMQHTPERWD 709
            :::..       |::||..|..|:.||||:.|||..|..:    .::..|.|     .|:|.|:.
Mouse   685 VKKNG-------AEQTLPTLGLTSNQLFFLGFAQVWCSVRTPESSHEGLITD-----PHSPSRFR 737

  Fly   710 VNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            |.|.||||.||...|.|..|:|||...||.|:
Mouse   738 VIGSLSNSKEFSEHFRCPPGSPMNPHHKCEVW 769

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	178/730 (24%)
Ece1	NP_001356106.1	M13	118..767	CDD:341056	179/731 (24%)