DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ECE1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_011539174.1	Gene:	ECE1 / 1889	HGNCID:	3146	Length:	778	Species:	Homo sapiens

Alignment Length:	765	Identity:	179/765 - (23%)
Similarity:	293/765 - (38%)	Gaps:	180/765 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPP 120
            :.:.:...|:.:.|||.|||.||||.|                              :...|:|.
Human   115 VTSSILSSMDPTVDPCHDFFSYACGGW------------------------------IKANPVPD 149

  Fly   121 QH------------------HPNGYSGASMTNV-RKVRAFYESCVAVEANASERRRFLMKILKDN 166
            .|                  |....|.||::.. ||.:.:|.:|:........|.:.||::::..
Human   150 GHSRWGTFSNLWEHNQAIIKHLLENSTASVSEAERKAQVYYRACMNETRIEELRAKPLMELIERL 214

  Fly   167 GGLRNVPNSNWQHNRQWVQ-----TLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTII 226
            ||        |.....|.:     ||..:..:|.......:.:..:.:....|.|...:..|
Human   215 GG--------WNITGPWAKDNFQDTLQVVTAHYRTSPFFSVYVSADSKNSNSNVIQVDQSGL--- 268

  Fly   227 PAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDI 291
                       |...||  |.|   ..|||.:...|            .:.:..:|.|.:|..|
Human   269 -----------GLPSRD--YYL---NKTENEKVLTG------------YLNYMVQLGKLLGGGD- 304

  Fly   292 QKPEEEFPPAIQ---------AQIYGARSRTGQERLRRQKGGMTLTEL--TSEMGNHLDFKMLVE 345
               ||...|.:|         |.|...:.:...|.|...|  :|..||  .:...|.|.|...:.
Human   305 ---EEAIRPQMQQILDFETALANITIPQEKRRDEELIYHK--VTAAELQTLAPAINWLPFLNTIF 364

  Fly   346 VILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNE----LNQPPEEAPSQ----- 401
            ..:|......:.:...||::.:...:...:|..:..|:::..:.:    |:|..::|..:
Human   365 YPVEINESEPIVVYDKEYLEQISTLINTTDRCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVM 429

  Fly   402 ---------RARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMD 456
                     |.:.||..|:......||.||.:....:::|.....:..::.||.||... ::|||
Human   430 YGTKKTCLPRWKFCVSDTENNLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMD 494

  Fly   457 ENDRRAARTR------LSQYRVSLPDYQSLD--------LTDLQFQKSEDY----WRRLEIALKY 503
            |..|::|:.:      :..|...:.|.:.||        :.||.|:.:..:    ||.....|:.
Human   495 EETRKSAKEKADAIYNMIGYPNFIMDPKELDKVFNDYTAVPDLYFENAMRFFNFSWRVTADQLRK 559

  Fly   504 RSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHR 568
            ..:            :|...:....|.|..||.:..::...|:||||:|....||:|.:..:|..
Human   560 APN------------RDQWSMTPPMVNAYYSPTKNEIVFPAGILQAPFYTRSSPKALNFGGIGVV 612

  Fly   569 LASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYN-EPGEFRNATRLRE 630
            :...|..||||:|  ::........|...::..::..:||...|||:|..| ||...|:.  |.|
Human   613 VGHELTHAFDDQGREYDKDGNLRPWWKNSSVEAFKRQTECMVEQYSNYSVNGEPVNGRHT--LGE 675

  Fly   631 IIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAK----DNQ 691
            .|||..||..|:.||..|:::..       |:.:|..|..||.||||:.|||..|..:    .::
Human   676 NIADNGGLKAAYRAYQNWVKKNG-------AEHSLPTLGLTNNQLFFLGFAQVWCSVRTPESSHE 733

  Fly   692 DAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            ..|.|     .|:|.|:.|.|.||||.||...|.|..|:|||...||.|:
Human   734 GLITD-----PHSPSRFRVIGSLSNSKEFSEHFRCPPGSPMNPPHKCEVW 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	173/747 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	175/748 (23%)
ECE1	XP_011539174.1	PepO	114..769	CDD:226118	173/754 (23%)
ECE1	XP_011539174.1	M13	127..776	CDD:189000	176/749 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920