Protein Alignment Nepl13 and nep-2

DIOPT Version :9

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_494343.2
• Gene: nep-2 / 188090
• WormBaseID: WBGene00020230
• Length: 736
• Species: Caenorhabditis elegans
• Alignment Length: 825
• Identity: 182/825 - (22%)
• Similarity: 325/825 - (39%)
• Gaps: 189/825 - (22%)

  Fly     2 RATRSAWLGFLLELLLLFEIQLCDVTEARQNHMNRMQMSG-------NFPDSREEQLVRQ--KIA 57
            |.|| .|....|.||:||.:.|                 |       |:.||.:..|...  |.|
 Worm    16 RWTR-IWAIIALILLILFLLVL-----------------GAAIYFYINYKDSSDVCLSPGCIKTA 62

  Fly    58 TDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQH 122
            :.:...||.|.|||.||:|:|||||.:.|.   .||:..:....  ..:.:.|:..|.:.|....
 Worm    63 SVILSSMNSSVDPCDDFYEFACGQWIKGHP---IPDDAPSVSNF--ENLGQDLEFALKELLDEND 122

  Fly   123 HPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQWVQTL 187
            .|..|..::   |.|.:.||..|:    |.||        :.||                |..|.
 Worm   123 EPYDYETSA---VGKAKYFYNLCL----NESE--------ILDN----------------WRTTF 156

  Fly   188 GELRRNYGLDILLG--LEIDLNLQTM--------KGNTIYFGEPKLTIIPAEHCNALATRGAQVR 242
            .|:.:::|....||  ::.|.:::.:        |.::::    |.|:.|.:       :.:|
 Worm   157 DEVVKSFGGWPSLGHQMKPDASIEMLYADMVAKFKADSLF----KATVQPDD-------KNSQ-- 208

  Fly   243 DEVYELVQQQVTENLRDWF----------------------GMDTGEAARFAGDIIRFEFELCK- 284
            ..|..:.|.|:....||::                      ..|...|...|.:||.||..|..
 Worm   209 RHVLLIDQPQLNLFARDFYVAAENEERMAYLQLIRDVLILLDADRTRATLDAKEIIDFETALANI 273

  Fly   285 -----------------QMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTS 332
                             .:||.....|...:|............:.|:.        :|..:.|.
 Worm   274 TMADEHRHDIAELYTKITLGEMRRSLPHFNWPLFFNRMFKDLHEKNGKR--------ITFDDNTE 330

  Fly   333 EMGNHLDFKMLVEVILESQYPSQV---YLRSPEYVKHVVRTVKANNRITVGGYILYVALNELNQP 394
            .:....:|...::|:: .||.:::   ||....:.|.::|.:.....:|:  :..|..||.:|
 Worm   331 VVVYGYEFLRRLDVLI-PQYDNRLIVNYLEWCWFFKTMLRDLPDPFALTI--FKFYKTLNIMN-- 390

  Fly   395 PEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-----HVEW 454
               ....|...||.....|.|.....::.::.....||..::    ::|..:.|.|     ..:|
 Worm   391 ---VQKVRWHGCVTRINSLMPMATSAIYVKNHFDHEAKQQVE----EMISLIMESFVDLLLSEDW 448

  Fly   455 MDENDRRAARTRLSQY--RVSLPDYQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQ------FEA 511
            :.:..::.|:.::::.  ::..|||    |.|.....:|  ::..::   |..|..      :|.
 Worm   449 LTKETKQTAKQKVNEMKRKIGYPDY----LNDPAAVNNE--YKTFKV---YPGHYYQTKFSFYEQ 504

  Fly   512 LRGNDFGQDADGLD-------AFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRL 569
            .:.:...:..:.:|       |..|.|..||....::...|:||..:|:..:|.|:.:..:|..:
 Worm   505 YQRDVLERITEAVDRERWVAGAALVNAFYSPNTNEIIFPAGILQPVFYSKDFPSSMNFGGIGVVI 569

  Fly   570 ASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG-EFRNATRLREI 631
            ...:...|||.|  ::|.......|:..|:|.:.:.::|...|||||:.::.. :....:...|.
 Worm   570 GHEITHGFDDRGRLYDNLGNIRQWWDNATISKFEHKAQCIEKQYSSYVLDQINMQINGKSTKGEN 634

  Fly   632 IADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILD 696
            |||..||..|:.||..:  ::.|...|     .|..:|.|:.||||:.:||..|...::::|| .
 Worm   635 IADNGGLKQAYRAYKKY--EKRHSRPP-----RLPGVNLTHDQLFFLNYAQIWCGTMNDKEAI-R 691

  Fly   697 SMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .:...:|:|....|.||||||.:|.:.:.|..|:.||..:||.|:
 Worm   692 KLRTSEHSPGPIRVKGPLSNSYDFAKAYNCEPGSQMNPREKCRVW 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	160/744 (22%)
		M13	68..738	CDD:189000	159/745 (21%)
nep-2	NP_494343.2	PepO	61..736	CDD:226118	165/760 (22%)
		M13	73..734	CDD:189000	160/746 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920