Protein Alignment Nepl13 and nep-18

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_494297.1
• Gene: nep-18 / 186911
• WormBaseID: WBGene00019343
• Length: 701
• Species: Caenorhabditis elegans
• Alignment Length: 808
• Identity: 172/808 - (21%)
• Similarity: 279/808 - (34%)
• Gaps: 228/808 - (28%)

  Fly    40 SGNFPDSREEQLVRQK---IATDVQKYMNLSADPCTDFFEYACGQ----------WGRYHKRQLR 91
            |.|.|:...|....::   :...::.|.|.|.|||.||||:.||:          ||....:||.
 Worm    16 SSNAPNGSPETCWSKECVGVLAMIKNYQNASVDPCEDFFEHTCGRYSEHVMDDNSWGYVQYKQLL 80

  Fly    92 PDELSTAQQL--METKISEQLQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASE 154
            ....:.|::.  ..:|.:|||                            |.|.:||:..:....:
 Worm    81 YQVFAIARKTNKFNSKPNEQL----------------------------RIFTKSCLDRKEMDED 117

  Fly   155 RRRFLMKILKDNGGLRNVPNSNWQHNRQWVQTLGELRRNYGLDILLGLEIDLNLQTM-------- 211
            ..:.|...:::.||...: :.||...:            :.|..:|...:.:|...|
 Worm   118 TFQDLRNDIEERGGFPMI-DPNWNEEK------------FDLSDMLAKYLSINRNRMGFLSVEPY 169

  Fly   212 ---KGNTIYFGEPKLTIIPAEHC--------------------NALATRGAQVRDEVY-----EL 248
               :||.   ...:|.:.|..|.                    ..|.....::.:.:|     ||
 Worm   170 AAIEGNK---SVNRLYVSPGPHWVYNWAMGISIYKDSVAFMLRRLLKLENRELNETIYDKEFAEL 231

  Fly   249 VQQQVT-ENLRDWFGM----DTGEAARFAGDIIRF--EFELCKQM--------GEQDIQKPEEEF 298
            ||.:.. ..|.|:..:    |....:|...|:::.  |.:..|.:        .|:|.:|..|
 Worm   232 VQLEANFSTLADYRNLALDNDNMSKSRNLTDLVKMIPEIDWIKILKALARHGTSEEDEEKLLE-- 294

  Fly   299 PPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEY 363
                :..::||......|  .|:...:......|.:.|:|..:.|::|.|        |.    |
 Worm   295 ----RVTVHGAGEYFFGE--NRELARIATETPKSALANYLVVRQLIDVAL--------YF----Y 341

  Fly   364 VKHVVRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFP------------- 415
            .|...|..|..|.:....:                       |.......||
 Worm   342 DKDQPRQNKFYNHVDQQSF-----------------------CATQVASFFPMPSMNVFIESSQF 383

  Fly   416 -----QVLGEMFQRHVQRDNAKHDLDAVF--NDVIKALEEQFHVEWMDENDRRAARTRLSQYRVS 473
                 :|:.|||.:      .|.:.:.:|  |:.::....:|.:..::..|   .:..|.||...
 Worm   384 KIENLKVIEEMFVK------IKAEYEQIFTENEYLELEIREFLIRKLNAID---GKFGLDQYTEG 439

  Fly   474 LP----DYQSLDL--TDLQFQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAA 532
            .|    .|::|:.  ||..:|.....||       :.|.|..|.: .:|...|...|..|...||
 Worm   440 KPLLEKMYETLNFLDTDSPWQVYMKMWR-------HWSEQLVEHI-VHDTPLDPVNLKMFGTHAA 496

  Fly   533 LSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFD------DEGWNNHPQATAQ 591
            ..|......:....|..|:.:..:|.:..|..||:.:...:..|||      ||.....    ..
 Worm   497 YQPYPNHFYINLPYLTYPWMDADFPANTNYGYLGYVIGHEIGHAFDHFHRKLDESGRQQ----QY 557

  Fly   592 WNEVTMSG---YRNASECQRAQYSSYLYNEPGE--FRNATRLR-EIIADGSGLNLAFNAYLAWLE 650
            |...|.|.   |....:|.|.|||:  |.|||.  |.|.|..| ||..|..|:..||..: ..::
 Worm   558 WFTETNSSNTEYELREKCLRDQYSA--YKEPGYDFFMNGTHCRYEIAGDHMGIRTAFRVF-EKVK 619

  Fly   651 QQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKD--NQDAILDSMPLMQHTPERWDVNGP 713
            ::|        :..|..|..:..||||..:|..:|   |  |.:.:..:|...||...|:.|||.
 Worm   620 KED--------RFRLPGLEMSEEQLFFYNYAFRQC---DVYNPNKLPRNMLARQHPTNRYRVNGV 673

  Fly   714 LSNSAEFGREFGCALGTPMNSGDKCLVY 741
            :.|..||...|.|...:|||...||.:|
 Worm   674 IQNIPEFAEAFNCPKNSPMNPEMKCKLY 701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	162/772 (21%)
nep-18	NP_494297.1	M13	47..699	CDD:341056	163/773 (21%)