DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and Phex

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_035207.1	Gene:	Phex / 18675	MGIID:	107489	Length:	749	Species:	Mus musculus

Alignment Length:	747	Identity:	173/747 - (23%)
Similarity:	310/747 - (41%)	Gaps:	122/747 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 ATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELST--AQQLMETKISEQLQQLLTQPLP 119
            |..:...:|||.|||.:||.:||..|   ......|:::.:  ....:...:..:|:.||.:.:.
Mouse    63 AAAIMSKVNLSVDPCENFFRFACDGW---ISNNPIPEDMPSYGVYPWLRHNVDLKLKALLEKSVS 124

  Fly   120 PQHHPNGYSGASMTNVRKVRAFYESCV---AVE-ANAS------ERRRFLMKILKDNGGLRNVPN 174
            .:.....        |:|.:..|.||:   |:| |:|.      ....|...:|:.|.|    |.
Mouse   125 RRRDTEA--------VQKAKILYSSCMNEKAIEKADAKPLLHILRHSPFRWPVLEANIG----PE 177

  Fly   175 SNWQHNR-QWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRG 238
            ..|...: ..:|||...|..|...:.:.|.:..:.:....:.:...:..|::...|......|..
Mouse   178 GVWSERKFSLLQTLATFRGQYSNSVFIRLYVSPDDKASNEHILKLDQATLSLAVREDFLDNTTEA 242

  Fly   239 AQVRDEVYE-LVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAI 302
            ...||.:|: :|...|.      .|.::..|......::|.|.::.      :|..|.|
Mouse   243 KSYRDALYKFMVDTAVL------LGANSSRAEHDMKSVLRLEIKIA------EIMIPHE------ 289

  Fly   303 QAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQ-YP--------SQVYL 358
                    :||.:....:    |.::|| |.|....|:...::.::::: ||        ..|.:
Mouse   290 --------NRTSEAMYNK----MNISEL-SAMIPQFDWLGYIKKVIDTRLYPHLKDIGPSENVVV 341

  Fly   359 RSPEYVKHVVRTVKANNRITVGGYI----LYVALNELNQPPEEAPSQRAR-------------QC 406
            |.|:|.|.:.|.:.|..:.|:..|:    :|..:..|::..:....:.:|             :|
Mouse   342 RVPQYFKDLFRILGAERKKTIANYLVWRMVYSRIPNLSRRFQYRWLEFSRVIQGTTTLLPQWDKC 406

  Fly   407 VQVTQRLFPQVLGEMFQR-HVQRDNAKHDLDAVFNDV----IKALEEQFHVEWMDENDRRAA--R 464
            |...:...|.|:|:||.. |.|.|. |..::.:...|    |..||::  .||||...:|.|  :
Mouse   407 VNFIESALPYVVGKMFVNVHFQEDK-KEMMEELIEGVRWAFIDMLEKE--NEWMDAGTKRKAQEK 468

  Fly   465 TRLSQYRVSLPD------YQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQF----EALRGNDFGQ 519
            .|....:|..|:      |.:.||..::|.:| ||:..:....||.:...|    :|:...::..
Mouse   469 ARAVLAKVGYPEFIMNDTYVNEDLKAIKFSES-DYFGNVLQTRKYLAQSDFFWLRKAVPKTEWFT 532

  Fly   520 DADGLDAFEVRAALSPRQQMVLVGWGLLQAPYY-NYYYPKSLKYALLGHRLASALVQAFDDEG-- 581
            :...::||     .|.....:....|.||.|:: ...||:||.|..:|..:.......||:.|
Mouse   533 NPTTVNAF-----YSASTNQIRFPAGELQKPFFWGTEYPRSLSYGAIGVIVGHEFTHGFDNNGRK 592

  Fly   582 WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG-EFRNATRLREIIADGSGLNLAFNAY 645
            ::.:......|:..:...::..::|...|||:|.:.:.| ..:....|.|.|||..||..||.||
Mouse   593 YDKNGNLDPWWSVESEEKFKEKTKCMINQYSNYYWKKAGLNVKGKRTLGENIADNGGLREAFRAY 657

  Fly   646 LAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDV 710
            ..|:..:    |..:.:..|..:.|||.||||:.:|..|| .....:|..:.:.:..|:|.::.|
Mouse   658 RKWINDR----RQGVEEPLLPGITFTNNQLFFLSYAHVRC-NSYRPEAAREQVQIGAHSPPQFRV 717

  Fly   711 NGPLSNSAEFGREFGCALGTPMNSG-DKCLVY 741
            ||.:||..||.:.|.|...:.||.| |.|.::
Mouse   718 NGAISNFEEFQKAFNCPRNSTMNRGADSCRLW 749

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	167/729 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	168/731 (23%)
Phex	NP_035207.1	PepO	67..741	CDD:226118	168/733 (23%)
Phex	NP_035207.1	M13	74..747	CDD:189000	168/732 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920