Protein Alignment Nepl13 and nep-22

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_509528.1
• Gene: nep-22 / 181144
• WormBaseID: WBGene00020788
• Length: 798
• Species: Caenorhabditis elegans
• Alignment Length: 780
• Identity: 153/780 - (19%)
• Similarity: 276/780 - (35%)
• Gaps: 171/780 - (21%)

  Fly    67 SADPCTDFFEYACGQW-GRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGA 130
            :.|||.||:.:.|.:: .....::|....|.|..|......||.:..|              |..
 Worm    82 TVDPCQDFYAFTCNKFLQNTDLQKLGRSRLGTYDQAQVDVYSEIVAAL--------------SKI 132

  Fly   131 SMTNV------RKVRAFYESCVAVEANASERRRFL-MKILKDNGGLRNVP--NSNWQHNRQWVQT 186
            .:|:.      |..:|.:|:|....|:.:::...: .:|....||   ||  ....:.|..:...
 Worm   133 DVTSTTTSKTERITKAAFETCKNNLASPADKTAVVYAEITSLFGG---VPFFGEPLKTNVDYWMV 194

  Fly   187 LGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQ 251
            .|::.:.:.:..|.......:.:....|.:|.|.|.|::          .|...|:.:....|.|
 Worm   195 AGQIEQKHAVGTLTYTIASSDYKDHTKNALYTGPPGLSL----------ARDFYVKPQYIAEVNQ 249

  Fly   252 QVTE--NLRDWF--------GMDTGEAARFAGDIIRFEFELCKQMGEQD-IQKPEEEFPPAIQAQ 305
            :|::  :|...|        |.|...||  |.:::.||.::.......| ::..::::.|
 Worm   250 RVSDVNDLLTAFANAAKKNVGADALLAA--AQEVVNFEVQIAMASWPDDLLRNYQQQYNP----- 307

  Fly   306 IYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVK--HVV 368
             |...|.|...|....|.  .|.:|...:.:..|         ::.|  .:.:..|.|..  :.|
 Worm   308 -YNIASATTAYRAINWKS--YLGQLFHGVASDAD---------QANY--NIVVTEPSYFAWLNSV 358

  Fly   369 RTVKANNRITVGGYILYVALNE----LNQPPEEAPSQR--------------------------- 402
            ...|.:|...|..|::...|.:    :|....:..|..
 Worm   359 FDGKTSNSTVVANYMIAQLLADESDFINPATAKVSSDTNYIHYALRNGRGIKKIGKREYRMADLD 423

  Fly   403 --ARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-----VEWMDENDR 460
              :..|:.:.....|...|.::   |:..:.::.:.|...|....:...|.     :.|||...:
 Worm   424 GISEGCMDLLTAYMPYGTGYVY---VKSKSERNKVQADVKDQTTLIINNFQGMIDSLNWMDTFSK 485

  Fly   461 RAAR-----------------------TRLSQYRVSLPDYQSLDLTDLQFQKSEDYWRRLEIALK 502
            ..|.                       |.:..|.   .||.|  :.||..:...|.:....:..|
 Worm   486 NRAHNKSDSLVKNFGWPEAMFGDFNDFTTVDAYN---QDYAS--IIDLYTKDKNDIYGIFAVLKK 545

  Fly   503 YRSHQQFEALRGNDFGQDADGLDAFE----VRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYA 563
            ....::|..:    .|:.||..:..:    |.|...|.:..:...:.....||||..||::..:|
 Worm   546 GMEVREFFRI----MGEPADRTNFLQSPAMVNAWYQPERNSITFPYAAWNPPYYNLNYPQAYNFA 606

  Fly   564 LLGHRLASALVQAFDDEGWN---NHPQATAQWNEV------TMSGYRNASECQRAQYSSYLYNE- 618
            ..|......|...:||||..   |.......||:.      :.||:.:.::|...|:|:....|
 Worm   607 GQGGTGGHELTHGYDDEGVQFGFNGELTDCSWNKCGWMDTNSSSGFIDMAQCVVTQFSTQCCPEK 671

  Fly   619 PGEF---RNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSEL-NFTNTQLFFIY 679
            .|..   ..||...|.|||..|...|:.:|    .|.....|..:.::.|..| |:|..|:|:|.
 Worm   672 TGNIHCANGATTQGENIADLGGQQAAYRSY----RQYVATTRKGVEEDRLPGLENYTPNQIFWIT 732

  Fly   680 FAQTRCWAKDNQDA-ILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPM--NSGDKCLVY 741
            :..:  |.....|| ::..:....|:|.:...|..:.:..|||::|||..|:||  ....:|.|:
 Worm   733 YGYS--WCMKQSDANLVHQLLTNPHSPAQCRTNQVMQDIPEFGKDFGCVRGSPMYPEPSGRCKVW 795

  Fly   742  741
             Worm   796  795

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	151/774 (20%)
nep-22	NP_509528.1	M13	83..793	CDD:341056	151/775 (19%)