DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and nep-1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_496490.2	Gene:	nep-1 / 174787	WormBaseID:	WBGene00013926	Length:	754	Species:	Caenorhabditis elegans

Alignment Length:	788	Identity:	182/788 - (23%)
Similarity:	309/788 - (39%)	Gaps:	203/788 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 QKIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMET--KISEQLQQLLTQ 116
            |:.:..:||.:|||.|||.|||||||..|...|.   .||:|::..|...|  |:..::::|
Worm    70 QEASRLLQKSLNLSLDPCDDFFEYACRAWVDSHP---IPDDLTSYSQFTATREKVLAEMRKL--- 128

  Fly   117 PLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQ--H 179
                  :.:..|..:..::..::..|.:|:..|.:.:...|.|::.:|..|        .|.  |
Worm   129 ------YEDNTSIPTSKSIALIKQIYNTCMDTEKHNAVGARDLLEKIKTYG--------YWPMVH 179

  Fly   180 NRQWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIY---------FGEPKLTIIPAEHCNALA 235
            |.:|                  .|...:|..:..|||.         ||       |||....::
Worm   180 NEKW------------------RESTFDLTKLLSNTIQSRDVSVFFDFG-------PAEDSRNVS 219

  Fly   236 TR-----------GAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGD--------------- 274
            .|           |...||  |.|.:::..:.::.:.....|:...:..|
Worm   220 RRLLSFDQGSLGLGYSTRD--YYLDEKKYEKQMKAYRKYTIGKVRYYTEDAGMAVNESKIESDVD 282

  Fly   275 -IIRFEFELCK-QMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNH 337
             ||.||.|..: .:.|:|.:.         ..::|..|      |....|..|::
Worm   283 EIIAFEKEWAQILVAEEDRRN---------YTKLYNVR------RFDDLKEYMSI---------- 322

  Fly   338 LDFK--------MLVEVILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILY----VALNE 390
            :|:|        .||...|::. || :.:...||::.:...::..:...|..|||.    ....|
Worm   323 IDWKKLTLSTTPFLVHSYLKTN-PS-IIISDVEYLQKMNTLLQNTDPRIVTNYILLRWAGSWSQE 385

  Fly   391 LNQPPEEAPSQ-------------RARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDV 442
            :.:..|:...:             |.:.||...........|.|:.|.....|||:....:..|:
Worm   386 IGKKYEDLQQEFAFQMYGRKQRQPRWKDCVSSAGGKLSYASGSMYVRKYFDANAKNTTLDMITDL 450

  Fly   443 IKALEEQFHV-EWMDENDRRAARTRLSQY--RVSLPDYQSLDLTDLQFQKSEDYWRRLEIA---- 500
            .:|.....|. :|||...::.|..:..|.  ::..||:      .|..:|.:|:::.||.|
Worm   451 QEAFRNMMHANDWMDAETKKYALEKADQMLKQIGYPDF------ILNDEKLDDWYKGLEGAPEDS 509

  Fly   501 --------LKYRSHQQFEALRGNDFGQDADGLDAFE-------VRAALSPRQQMVLVGWGLLQAP 550
                    :::|::..:..|        .:.::.||       |.|..||.:..:....|:||.|
Worm   510 FSQLVEKSIQWRNNFYYRRL--------LEPVNRFEFISSAAVVNAFYSPTRNAIAFPAGILQQP 566

  Fly   551 YYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSS 613
            :::..:||:|.|..:|..:...:...|||.|  ::|.......|:..|.|.:...::|...||:.
Worm   567 FFDARFPKALNYGGIGAVIGHEITHGFDDTGRQFDNVGNLRDWWDNTTSSKFNERTQCIIEQYAD 631

  Fly   614 YLYNEPGEFRNATRLR--------EIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNF 670
            ...       ..|.||        |.|||..|:..||.||.::||:...:...|...|:|
Worm   632 VKL-------RGTDLRINGKLTQGENIADNGGIKQAFKAYKSYLEKHGGQEARLPQFESL----- 684

  Fly   671 TNTQLFFIYFAQTRCWAK--DNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMN 733
            ||.||||:.:||..|.||  :.:..:|.:.|   |:||...||..|:|..||...|.|..|:|||
Worm   685 TNEQLFFVGYAQVWCGAKTPETKTLLLLTDP---HSPETARVNTVLTNQPEFAEAFKCPAGSPMN 746

  Fly   734 SGDKCLVY 741
            ...:|:|:
Worm   747 PTKRCVVW 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	174/768 (23%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	174/769 (23%)
nep-1	NP_496490.2	PepO	80..754	CDD:226118	178/776 (23%)
nep-1	NP_496490.2	M13	85..751	CDD:189000	174/768 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920