DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and nep-26

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001022540.1	Gene:	nep-26 / 174593	WormBaseID:	WBGene00014171	Length:	807	Species:	Caenorhabditis elegans

Alignment Length:	785	Identity:	165/785 - (21%)
Similarity:	290/785 - (36%)	Gaps:	167/785 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 PDSREEQLVRQKIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISE 108
            |.:.||.::   .|:.:.|.::.|.:||.:|:::|||.|.. ....|:.|..:|..:...|...:
Worm   103 PCTSEECVM---TASRLLKRVDQSVEPCDNFYQFACGGWIN-QSVNLKYDSWNTLYETQRTAHDQ 163

  Fly   109 QLQQLLTQPLPPQHHPNGYSGASMTNV--RKVRAFYESCVAVEANASERRRFLMKILKDNGG-LR 170
            .:|.:        |..|..|....||.  |.....||.|:..:...........:.:.:.|| :.
Worm   164 IVQAM--------HKINDGSYPLPTNAGERAAAKMYEQCMDTDTLEQTGLHLWERFVDELGGWMP 220

  Fly   171 NVPNSNWQHNRQWVQTLGE----LRR-----------NYGLDILLGLEIDLNLQTMKGN--TIYF 218
            .:.|...:....:...|.|    .||           ||.:..|....:::|....|.:  |||.
Worm   221 ELKNGALEQEESFEIELDEDEKKRRRFEIEDIILSAFNYSVFPLFWAGVEVNYLNSKEHLITIYE 285

  Fly   219 GEPKLTIIPAEHCNALATRGAQVRDEVYELVQ--------QQVTENLRDWFGMD-TGEAAR-FAG 273
            ..|.|......|.|...|     .:.:|..::        |||.|.|....|.| |.|..| ...
Worm   286 QLPILLAPEKYHYNKELT-----PEMIYGKMEGPPVTRALQQVGEELSAVLGFDSTDEKVRMMIA 345

  Fly   274 DIIRFEFELCKQMGEQDIQKPE----------EEFPPAIQAQIYGAR-------------SRTGQ 315
            ::|..|:::.........:|.|          :|..|||....:.:|             .:||.
Worm   346 NMIYLEYQITMAGSTFYKEKKERYTVVMLRELQEIAPAINWHYFLSRLVGENLSHSEPIALKTGT 410

  Fly   316 ----------ERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVRT 370
                      |:|::.:.|:.:      :.|::.:|   .::....|.|.
Worm   411 QWIPILSAIVEKLKQSRSGVAV------LKNYVKWK---TIMFHLAYASP--------------- 451

  Fly   371 VKANNRITVGGYILYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDL 435
             |..:.:......||          ..|.|||...||.....:||..|..:.::....|:.:.::
Worm   452 -KCRDGLLWMAVSLY----------SGAASQRKEFCVLRLSGIFPLSLPSILRKIDGIDHTEKNV 505

  Fly   436 DAVFNDVIKALEEQFHVEWMDEN---DRRAARTRLSQYR-----VSLPDYQSLDLTDLQFQKS-- 490
            .||.| :...::|::.......|   ||......:.:..     :..||...   :|.:.:|.
Worm   506 KAVQN-IADRIQEKYEEMVRSSNLFSDRETRENVIDKVNNMTKFIGFPDAMR---SDYEMEKEAV 566

  Fly   491 --ED--YWRR-LEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSP-----RQQMVLVGWG 545
              .|  :|.. |..:..|:  ::.:.||     ...|.....:.|.|:|.     .:.:|.:.:.
Worm   567 RLHDTLFWSMVLGSSSVYK--ERLQRLR-----LPVDPRSWVDTRPAISVPAHNYERNLVQIPFD 624

  Fly   546 LLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQAT--AQWNEVTMSGYRNASECQR 608
            .|:.||.:.:......||.:|..:...|..|||.:|..:.|...  ..|:..::..::...:|..
Worm   625 SLRLPYADEHQLDFANYAGIGTIIGHELTHAFDGQGKLHGPTGNLGVWWSTDSIREFKAREQCFV 689

  Fly   609 AQYSSYLYNEPGEFRNATR--LREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFT 671
            .||:..:.:..   .||.:  |.|.|||..||.:|:.|:.:...|...:: |.|.|       ::
Worm   690 KQYAGLMDSHD---MNAAKEGLYENIADQVGLKVAYEAWKSNGNQNSGRM-PGLEK-------YS 743

  Fly   672 NTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGD 736
            ..||||:.:.|..|..:..      |..|..|..||..:.|.|.||.||...:.|:..:.||..|
Worm   744 QDQLFFLAYTQGWCALRSK------SYKLQPHMEERIRMLGSLQNSPEFASAWKCSSESFMNPPD 802

  Fly   737 KCLVY 741
            ||.::
Worm   803 KCSIW 807

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	155/755 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	157/756 (21%)
nep-26	NP_001022540.1	PepO	111..807	CDD:226118	162/775 (21%)
nep-26	NP_001022540.1	M13	124..805	CDD:189000	158/757 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020