Protein Alignment Nepl13 and nep-5

DIOPT Version :9

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_001364754.1
• Gene: nep-5 / 173933
• WormBaseID: WBGene00017393
• Length: 694
• Species: Caenorhabditis elegans
• Alignment Length: 720
• Identity: 122/720 - (16%)
• Similarity: 253/720 - (35%)
• Gaps: 180/720 - (25%)

  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLP 119
            |.:.::.:.|:.|.:||.:|..:.|   ..::.|:               |..|:|.:|:.....
 Worm   115 KYSAELLELMDSSVNPCENFHHHVC---NGFNPRK---------------KDFERLMKLINIQEK 161

  Fly   120 PQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVP----NSNWQHN 180
            |.|.       ...||  ||.....|...:.....:...|..|:     |..:|    |::|...
 Worm   162 PDHR-------KAVNV--VRRMLSKCAMGKTEEIHQVGRLSSII-----LPGLPFPLLNNSWTKP 212

  Fly   181 RQWVQTLGELRRNYG--------LDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATR 237
            ...:.| ......|.        ..|:|....|.....:|.::    :.:.::...:..:.:.|
 Worm   213 SDPIST-SNSSTTYSYPFLTKILAHIILHNPDDAGFVGIKPSS----DSEFSLFVVKPFSPVLT- 271

  Fly   238 GAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMG-----EQDIQKPEEE 297
            ..:.|: :|:::::...|:..:  ||            |..||:..:|:.     :..::|.|.:
 Worm   272 NFKFRN-MYDILKRNAPESSTN--GM------------IDLEFDRQRQLNDVIKLQTKLEKIEFK 321

  Fly   298 FPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQY---PSQVYLR 359
            ..|.:                      :.|||:..:| ..:|:|.|::..:.:.|   ..:||..
 Worm   322 ADPEV----------------------VNLTEIQRQM-PIIDWKRLIDSWIPNGYAHLKEKVYGF 363

  Fly   360 SPEYVKHVVRTVKANNRITVGGYI-LYVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQ 423
            :..|.:.:...:.:....|:..:: |..:...|.   .|..|.....|:.......|   |::..
 Worm   364 NTSYYEEINAIISSTPSETIYNFLFLRFSFKFLR---TEVASDLEDTCLHQLSTTIP---GKIVL 422

  Fly   424 RHVQRDNAKHDLDAVFNDVIKALEEQFH-----VEWMDENDRRAARTRLSQYRVSLPDYQSLDLT 483
            ...:...|.:    :.|.::..:::|..     ::|||......|:.:.::.: ::..:...||.
 Worm   423 YGSEEPEALN----LLNGMLHTIKDQLKRSLATLKWMDSRGIEEAQKKFNKTK-TVFGFTGEDLI 482

  Fly   484 DLQFQK---SEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAF-EVRAALSPRQQMVLVGW 544
            |....|   ..:|...|:..|.:::...|:::..|:       :..| ......|..:..:.:..
 Worm   483 DELVGKITPESNYISTLQNVLLWQTRNMFKSVAENN-------VTVFLNSEVFYSVEKNEITISR 540

  Fly   545 GLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGW-----NNHPQATAQWNEVTMSGYRNAS 604
            .||..|:.:...|....:|.:..::...::..||:.|.     .||..   .||..|...::...
 Worm   541 ALLHYPFMSANLPNYTNFATIASKILPQMIHIFDERGRFYDSDGNHRN---WWNTETERYFQIIV 602

  Fly   605 ECQRAQYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELN 669
            :|    :...:.|               ..|..:::.:|||       |....|.   .||..:.
 Worm   603 QC----FDGMMQN---------------VFGVSVSIGWNAY-------DSTKEPY---ATLPGIQ 638

  Fly   670 FTNTQ-LFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMN 733
            .::.: |||....:|.|                  |.:..:||..|::..:|...|.|..||.||
 Worm   639 QSSDEALFFYSMVKTMC------------------TSDPDNVNEALASVPQFNSAFKCNNGTKMN 685

  Fly   734 SGDKC 738
            ...||
 Worm   686 PPTKC 690

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	117/704 (17%)
		M13	68..738	CDD:189000	117/705 (17%)
nep-5	NP_001364754.1	GluZincin	128..691	CDD:417498	119/707 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.810