DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and nep-12

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001364537.1	Gene:	nep-12 / 173824	WormBaseID:	WBGene00017842	Length:	832	Species:	Caenorhabditis elegans

Alignment Length:	838	Identity:	177/838 - (21%)
Similarity:	316/838 - (37%)	Gaps:	207/838 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 FLLELL------------------LLFEIQLCDVTEA------RQNHMNRMQMSGNFPDSREEQL 51
            |:|.||                  |:...:||..||.      ..||:       |:.......|
Worm    95 FILTLLISISFITIVAILSDGFSTLISGSELCSNTEGDAYEVKNSNHV-------NYGSDNSTCL 152

  Fly    52 VRQ--KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLL 114
            ..:  ::|......||..|:||.||:|:||   |:|..|::..:.......|.|.|  :::.:.|
Worm   153 TPECIRLAASYLNNMNRDANPCEDFYEFAC---GKYATRKVIAEHEKKVTVLSEMK--KEMDRHL 212

  Fly   115 TQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQH 179
            ...|......|     :..:::..:.:::||:...:......:.||.::.:.||...:.|:.:..
Worm   213 KDILEKTSREN-----TTRSMKLAQIYFDSCMDEFSQDDLGVQPLMSMISNLGGWPLLTNARFDS 272

  Fly   180 -NRQWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTI--------IPAEHCNALA 235
             :.||....|.|.. ||:|.:..:.:..:......|.:.|..|||.:        :|:.:
Worm   273 IDFQWEVLAGHLAL-YGVDGIFRVFVHSSFDDSDKNVLMFSPPKLFLEKKKFYREVPSSN----- 331

  Fly   236 TRGAQVRDEVYELVQQQVTENLRDWFGMD----TGEAARFAGDIIRFEFELCKQMGEQDIQKPEE 296
                     ||....:|...:|....|:|    ||.......|||.||
Worm   332 ---------VYLQYYRQYILSLLSLLGVDMEDETGVIEYQVDDIIDFE----------------- 370

  Fly   297 EFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELT---SEMGNHL---DFKMLVEVILESQY--- 352
                                   |:...:|..||:   |.:.|.:   :||...:.|....:
Worm   371 -----------------------RRIANLTRIELSRNHSSINNMITFGEFKRKYDKINWDAFFNE 412

  Fly   353 ---------PSQVYLR--SPEYVKHVVRTVKANNRITVGGYILYVALNELNQPPEEAPSQRARQC 406
                     |..:.:.  ...|..::...:|:....::..::::..::..:.   ..|::..:..
Worm   413 EMRGNLGRMPDSLVINVVDVNYFDNLYSLIKSKPLSSINNFLMWCLVSNYDM---YLPAKYRKPM 474

  Fly   407 VQVTQR---------LFPQVLGEMFQ--------RHVQRDNAKHD---LDAVFNDVIKALEEQ-F 450
            :...|:         |:...:||:.:        .:.|:...|.|   .:.:..|:.||:|:. .
Worm   475 LDFRQKMYGVSSDDPLWEVCVGEVRENLAMPLSTEYAQKFFTKKDKLVAEDMIRDLKKAMEQTLL 539

  Fly   451 HVEWMDENDRRAARTRLSQ--YRVSLPD-----------YQSLDLTDLQFQKSEDYWRRLEIALK 502
            :.:|:||:.|.||..:|..  :::..||           |..:.||..|:..:       .|:||
Worm   540 NADWIDESTREAALMKLDAMGHKIGFPDSLLNETAVLLPYAGVRLTANQYFDN-------AISLK 597

  Fly   503 ---YRS-----HQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKS 559
               ||.     |:....:   |:......:|||.....     ..::...|:||.|.:....|..
Worm   598 KAAYRDALSKLHRTPSLI---DWASPIIAVDAFHYFTG-----NEIIFPAGILQFPMFVPDAPAF 654

  Fly   560 LKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG-E 621
            ..|..:|..:...:...:||.|  :::.......|:..||:.::...:|..|||.|.:..:.| :
Worm   655 SNYGAIGMGIGHEITHGYDDLGAQYDDKGNLRGWWHTETMTTFQKKKQCFVAQYGSKIEPQTGRK 719

  Fly   622 FRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKET--LSEL-NFTNTQLFFIYFAQT 683
            ......:.|.|||..||.:||.||         :||....|||  |..| :|:..||||:.:|.|
Worm   720 VDGKMTIGENIADNGGLRVAFQAY---------QLRSDREKETRRLPGLTDFSPNQLFFLAYANT 775

  Fly   684 RCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|.|. ...||...|....|:...:.||.||.|...|.:||.|.:|:|||..:||.::
Worm   776 WCEAL-KPSAIDHIMDTDVHSLGMFRVNVPLQNLPAFSKEFDCPIGSPMNPFEKCRIW 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	158/749 (21%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	159/750 (21%)
nep-12	NP_001364537.1	M13	171..830	CDD:341056	160/751 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	6	5.880