DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and Mme

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_001276391.1	Gene:	Mme / 17380	MGIID:	97004	Length:	750	Species:	Mus musculus

Alignment Length:	773	Identity:	172/773 - (22%)
Similarity:	300/773 - (38%)	Gaps:	172/773 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQW----------GRYHKRQLRPDELSTAQQLMETKISEQ 109
            |.|..:.:.|:.|.:||||||:||||.|          .||....:..|||       |..:.:.
Mouse    64 KSAARLIQNMDASVEPCTDFFKYACGGWLKRNVIPETSSRYSNFDILRDEL-------EVILKDV 121

  Fly   110 LQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPN 174
            ||:..|:              .:..|:|.:..|.||:...|..|...:.|:|:|.|..|. .|.:
Mouse   122 LQEPKTE--------------DIVAVQKAKTLYRSCINESAIDSRGGQPLLKLLPDIYGW-PVAS 171

  Fly   175 SNWQ--HNRQWV--QTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKL----------TI 225
            .||.  :...|.  :::.:|...||..:|:...:..:.:....:.|:|.:|:|          |.
Mouse   172 DNWDQTYGTSWTAEKSIAQLNSKYGKKVLINFFVGTDDKNSTQHIIHFDQPRLGLPSRDYYECTG 236

  Fly   226 IPAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQD 290
            |..|.|.|.    ......|..|::|:.:      ..:|..:.:.....::..|.|:...
Mouse   237 IYKEACTAY----VDFMISVARLIRQEQS------LPIDENQLSLEMNKVMELEKEIANA----- 286

  Fly   291 IQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFK----------MLVE 345
            ..|||:...|.:   :|..               |||.:|.:.....::.|          ::..
Mouse   287 TTKPEDRNDPML---LYNK---------------MTLAKLQNNFSLEVNGKSFSWSNFTNEIMST 333

  Fly   346 VILESQYPSQVYLRSPEY------------------------VKHVVRTVKANNRITVGGY--IL 384
            |.:..|...:|.:.:|||                        :..:|.::..|.:.:...:  .|
Mouse   334 VNINIQNEEEVVVYAPEYLTKLKPILTKYSPRDLQNLMSWRFIMDLVSSLSRNYKESRNAFRKAL 398

  Fly   385 YVALNELNQPPEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQ 449
            |...:|         :...|:|...........:|.::........:||    |..|:|..:.|.
Mouse   399 YGTTSE---------TATWRRCANYVNGNMENAVGRLYVEAAFAGESKH----VVEDLIAQIREV 450

  Fly   450 F-----HVEWMD-ENDRRAARTRLS-QYRVSLPDYQSLDLTDLQFQKSEDYWRRLEIALKYRSHQ 507
            |     .:.||| |..::|....|: :.|:..||    |:...:.:.:.:|     :.|.||..:
Mouse   451 FIQTLDDLTWMDAETKKKAEEKALAIKERIGYPD----DIISNENKLNNEY-----LELNYREDE 506

  Fly   508 QFEALRGN-DFGQD------ADGLDAFE-------VRAALSPRQQMVLVGWGLLQAPYYNYYYPK 558
            .||.:..| .|.|.      .:.:|..|       |.|..|..:..::...|:||.|:::.....
Mouse   507 YFENIIQNLKFSQSKQLKKLREKVDKDEWISGAAVVNAFYSSGRNQIVFPAGILQPPFFSAQQSN 571

  Fly   559 SLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPG- 620
            ||.|..:|..:...:...|||.|  :|........|.:.:.:.:::.|:|...||.::.::..|
Mouse   572 SLNYGGIGMVIGHEITHGFDDNGRNFNKDGDLVDWWTQQSANNFKDQSQCMVYQYGNFSWDLAGG 636

  Fly   621 -EFRNATRLREIIADGSGLNLAFNAYLAWLEQQ-DHKLRPLLAKETLSELNFTNTQLFFIYFAQT 683
             .......|.|.|||..|:..|:.||..::::. :.||.|        .|:..:.||||:.|||.
Mouse   637 QHLNGINTLGENIADNGGIGQAYRAYQNYVKKNGEEKLLP--------GLDLNHKQLFFLNFAQV 693

  Fly   684 RCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|.....:.|: :|:....|:|..:.:.|.|.|||||...|.|...:.||...||.|:
Mouse   694 WCGTYRPEYAV-NSIKTDVHSPGNFRIIGTLQNSAEFADAFHCRKNSYMNPERKCRVW 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	165/754 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	165/755 (22%)
Mme	NP_001276391.1	Stop-transfer sequence. /evidence=ECO:0000255	16..23
Mme	NP_001276391.1	M13	77..748	CDD:341056	166/756 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920