DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and nep-11

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_494538.1	Gene:	nep-11 / 173685	WormBaseID:	WBGene00017557	Length:	848	Species:	Caenorhabditis elegans

Alignment Length:	766	Identity:	173/766 - (22%)
Similarity:	299/766 - (39%)	Gaps:	164/766 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDEL---STAQQLMETKISEQLQQLLTQ 116
            :.||.....||.|.|||.||||:|||||...|.   .||::   .|.....| ::.:||:.||.|
Worm   168 RAATHFLNAMNTSVDPCDDFFEFACGQWNDQHP---IPDDMYGFGTFAYARE-QVRQQLRVLLEQ 228

  Fly   117 PLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRF----LMKILKDNGGLRNVP--NS 175
            .:..:..          ::...||.|.||:    |.::....    |.:.|.:.|   ..|  ..
Worm   229 EVVTESE----------SINMARATYRSCM----NKTQLDELMTGPLFETLTELG---EWPLLQE 276

  Fly   176 NWQHNR-QWVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGA 239
            ||...: .:...|...||:||:|:...|.|..:.:....||::..:..|.:            |.
Worm   277 NWDKTKFNFTSLLVNSRRDYGVDVFFQLYIYADSKNTSRNTLFIDQSTLAL------------GR 329

  Fly   240 QVRD------------EVYELVQQQVTENLRDWFGMDTGEAARFAG--DIIRFEFELCKQMGEQD 290
            ..||            ..|....:|:...|:....:...|:...|.  .||.||.||.|.:..:|
Worm   330 GTRDYYLNTTLFSSHMTAYRKYLRQIAHLLKTDGNLTRSESEMNADIEKIIDFEIELAKIIVAED 394

  Fly   291 IQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLVEVILESQY--- 352
                                .|....||..::....|..|..:    :|:....:.|..|..
Worm   395 --------------------ERRNNTRLYNKRQIQDLYNLLPQ----VDWVPFFQSIAPSDLTHL 435

  Fly   353 ---PSQVYLRSPEYVKHVVRTVKANNRITVGGYILY-----------------------VALNEL 391
               .:::.:...||::||...::..:...:..|:|:                       |...:.
Worm   436 FHNETEIIICEIEYLQHVSELIEKTDVGLLTNYVLWRVVQSNVRYLDERFEDIKQDFLKVMTGQQ 500

  Fly   392 NQPPEEAPSQRARQCVQVTQRLFPQVLGEMF-QRHVQRDNAKHD-------LDAVFNDVIKALEE 448
            ..||      |.:.|.||...:.|...|.:: |.|.| ::.||:       |...|.|:::
Worm   501 QSPP------RWKDCAQVPSTVLPLAAGAIYVQAHFQ-ESDKHEALRMIMHLRNSFADLVR---- 554

  Fly   449 QFHVEWMDENDRRAARTRLSQY--RVSLPD-----------YQSLDLTDLQFQKSEDYWRRLEIA 500
              ..:||||..:..|..:.:..  .:..||           |..|.::|     |:.|:..::.:
Worm   555 --QNDWMDEETKAVAIEKANSMINNIGYPDVTNDLPKLDKQYLGLSISD-----SDTYYYIMKKS 612

  Fly   501 LKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYALL 565
            :.:...::|:.|. ..|.:....:....|.|..||.:..:....|:||.|:::..:||::.|..:
Worm   613 VVWMQSREFQKLT-KPFDKHEFDISPAVVNAFYSPEKNAITFPAGILQPPFFSGTFPKAVNYGAI 676

  Fly   566 GHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNATRL 628
            |..:...:...|||:|  ::........|:|.:::.:.....|...||.:|...:. .||...:|
Worm   677 GAVIGHEITHGFDDQGSQYDKDGNLHNWWSESSLNSFDTRRRCIVEQYGNYTVPKT-NFRVNGKL 740

  Fly   629 R--EIIADGSGLNLAFNAYLAWLEQQDHKLR-PLLAKETLSELNFTNTQLFFIYFAQTRCWAKDN 690
            .  |.|||..|:..||.||..::.:...:.| |.|.:       :||.|:||:.:|...| .|..
Worm   741 TQGENIADNGGVKEAFQAYQKYVTENGEEPRLPGLQQ-------YTNEQIFFVSYAHFWC-GKKK 797

  Fly   691 QDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            :.|.:..:...:|:||.:.|.|.|||...|...:.|....|:|...||:|:
Worm   798 EAAAMQQVLTDEHSPEVFRVIGVLSNMQAFADVYKCPRNAPVNPDHKCIVW 848

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	166/747 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	165/748 (22%)
nep-11	NP_494538.1	PepO	174..848	CDD:226118	170/758 (22%)
nep-11	NP_494538.1	M13	181..845	CDD:189000	165/748 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020