DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and nep-10

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_494532.2	Gene:	nep-10 / 173684	WormBaseID:	WBGene00017555	Length:	711	Species:	Caenorhabditis elegans

Alignment Length:	815	Identity:	171/815 - (20%)
Similarity:	306/815 - (37%)	Gaps:	194/815 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SAWLGFLLELLLLFEIQLCDVTEARQNHMN-RMQMSGNF----------PDSR------EEQLVR 53
            |.|:.|.|.||||. :.|..||.    |:. .:.::..|          ||.:      |.|.|.
Worm    12 SPWIAFALNLLLLI-VFLALVTV----HIKMTIDVAPVFKSDDPLPRGDPDQKPATIDSETQTVD 71

  Fly    54 Q-----------KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKIS 107
            :           .:|.::..|.:.|.|||.||:::.||::  |....:....::|.:..:...|.
Worm    72 EPRNVCESPECITLAHELHNYKDPSVDPCQDFYQHFCGKF--YEHSAIGQGRMATKRSTLSKLIR 134

  Fly   108 EQLQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNV 172
            |.|.:            |..|.:...|..|  ..|..|           |.|.||    ..|.::
Worm   135 EFLLK------------NKTSTSKSENTMK--QVYAKC-----------RELQKI----SDLNSI 170

  Fly   173 PNSNWQHNRQWVQTLGELRRNYGLDILLGLE-------ID-------LNLQTMKGNTIYFGEPKL 223
            |          .|.|        |||...::       :|       .||..|....:..||..|
Worm   171 P----------PQAL--------LDIFSDIKKIGAWPVLDKDWDGSKFNLNEMLRQLVNLGETHL 217

  Fly   224 TIIPAEHCNALATRGAQVRDEVYELVQQQVTENL------RDWFGMDTGEAARFAGDIIRFEFEL 282
            ...   |.:.:|.....::..:.:.||:.|.|.:      .:...||.|    |:.|:..: |||
Worm   218 GFF---HFDFIARPYVLIKPPLKQGVQKSVLEKVVKMILEANEIKMDQG----FSEDLDEY-FEL 274

  Fly   283 CKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLTEL-TSEMGNHLDFKMLVEV 346
            ..::....:        |.....|.|......:...|    |:.|..: .|:|...|.  .|.:.
Worm   275 SNRIKIDKL--------PRTSRSIVGLLPDVRRINFR----GLILEMMPRSKMNRFLG--TLFQK 325

  Fly   347 ILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVALNELNQPPE----EAPSQRARQCV 407
            ::...:|  :::|..| ..|:...:::.:...:..|:::   |.::...:    ...|.|.| |.
Worm   326 VVTYHHP--LFVRDNE-TNHLDTIIRSTSNRALANYLIF---NFIHSSIKFLTFGLKSDRER-CE 383

  Fly   408 QVTQRLFPQVLGEMFQRH-VQRDNAKHDLDAVFNDVIKALE--EQFHVEWMDEND--------RR 461
            ::..:..|:....:|.|: |.:.|.:        :|.|..|  ::..:|.:.|:|        |.
Worm   384 KIVVQELPRPSLRVFMRNCVDKGNRE--------EVAKLTETVKENVLEMIRESDSFTPSVKKRV 440

  Fly   462 AARTRLSQYRVSLPDY----QSLD--LTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQD 520
            ..:.......:..||:    .:||  ..:|....|:.|::..:...:.|...|.|.|.|......
Worm   441 LKKVEAIGAIIGYPDHFDPPGTLDKEYENLTLDASDSYYKMSQKLHQLRLQHQMEFLAGQTPLSP 505

  Fly   521 ADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYYPKSLKYA----LLGHRLASAL-VQAFDDE 580
            :|  ...||.|....:...:.|....|..|:::..||:.:...    |:||....:: .:....:
Worm   506 SD--QVLEVNAHYDSKDNALTVLAPFLDDPFFDSTYPEYVNLIFTGFLIGHEFGHSIDPKILRRD 568

  Fly   581 GWNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEPGEFRNATR-LREIIADGSGLNLAFNA 644
            ||         :....|:.|...::|...||.:|...:.|:..|.|. :.||:.|..|.::.:.|
Worm   569 GW---------YKTEDMTEYGKRAQCLIDQYDNYDDPDHGKQMNGTYCIGEIVGDWVGRDVTWRA 624

  Fly   645 YLAWLEQQD-HKLRPLLAKE--TLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPE 706
            :    ::.| .|::.|:..|  .|.:|.|....|||       |..:..:.  |:.:....|..|
Worm   625 F----KKMDLSKMQKLIGFEDKNLDQLYFRIQSLFF-------CGPRSMKS--LEQLLSDPHPTE 676

  Fly   707 RWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .:.|||..||..:|.:.|.|.:|:|||...||.::
Worm   677 VFRVNGIYSNMPQFAKAFNCPIGSPMNPEKKCKMF 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	147/719 (20%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	148/720 (21%)
nep-10	NP_494532.2	M13	97..709	CDD:189000	149/721 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920