DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and nep-9

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	NP_494531.2	Gene:	nep-9 / 173683	WormBaseID:	WBGene00017554	Length:	700	Species:	Caenorhabditis elegans

Alignment Length:	786	Identity:	143/786 - (18%)
Similarity:	273/786 - (34%)	Gaps:	257/786 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPP 120
            :|.:::.|.:.:...|.||::..|..:..:.......|          .|..:.:.:|:...|
Worm    72 LAQELKAYSDTATKSCEDFYKATCENYKDHQALDRHRD----------CKKRKAVNKLVRGFL-- 124

  Fly   121 QHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNW---QHNRQ 182
            |...:.::..|.:.::.:   :..|..:..|.|     .:.|.||   ::.:  .:|   :||
Worm   125 QRDESTFTSESESAIKLI---FGKCDELSRNTS-----YLDIFKD---IKKI--GSWPVLEHN-- 174

  Fly   183 WVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYE 247
            |..::      :.||       |:..:.:|..:..||..||                    |:.:
Worm   175 WKDSM------FNLD-------DVIAKLVKLGSTDFGLFKL--------------------ELRK 206

  Fly   248 LVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSR 312
            |.           ||       .||      .|...||  ||:|.:        ::..|.|....
Worm   207 LA-----------FG-------HFA------VFVSSKQ--EQNIHQ--------LEKTILGILKA 237

  Fly   313 TGQERLRRQKGGMTLTELTSEMGNHLDFK--------------------MLVEVILESQYPSQVY 357
            .|.::.|:        ||:.::.::.|||                    .:||.:..|...:|:.
Worm   238 NGIQQDRK--------ELSDDLKDYSDFKNHLKEFYQEETYIEYRLYAGSIVENLGISSLTTQMA 294

  Fly   358 LRSP--EYVKHV-VRTVKANNRI------------------TVGGYILYVALNELNQPPEEAPSQ 401
            |:|.  :...|| .||:..|:.:                  |:..::::..::.:......|
Worm   295 LKSTGLDVFNHVNQRTLITNSSLFFGEENNLGMIIQKTPKRTLANFLIFHFIDVMTTDLANA--- 356

  Fly   402 RARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDLDAVFNDVIKALEE---------QFHVEWMDE 457
             .:.|.:....|.|:...::..|:...::|:.|:..:..|:...:.|         :||:.:..|
Worm   357 -TKACKETLIDLLPRASIQVLSRNFVNEDAQDDMVKMAQDLKTKITEMIDNSPFFTKFHLVFDAE 420

  Fly   458 NDRR-----AARTRLSQY--RVSLPDYQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGN 515
            ..::     .|...:::|  .|...|::.|:||     .|:..:|.::...:.||.|..|.|.|:
Worm   421 EQKKLIQKVKAIGIVTEYPQEVLDRDFERLNLT-----PSDSIYRTIQKLRRLRSEQLIEHLGGD 480

  Fly   516 DFGQDADGLDAFEVRAALSPRQQMVLVGWG----------------LLQAPYYNYYYPKSLKYAL 564
                    ||..:.|.            ||                ::..||::..||..:...|
Worm   481 --------LDPTDTRV------------WGSAHYDQTTNNLTIFAPIIDGPYFDTSYPNYVNQFL 525

  Fly   565 LGHRLASALVQAFDD-----------EGW---------NNHPQATAQWNEVTMSGYRNASECQRA 609
            :|..|...|.::.|.           |.|         :.|.:..|:..:.:....::.|:..|.
Worm   526 MGFILGRELGRSLDSVRIRKDEKGQTENWLKPESLKRFDEHLKCWAEKYDKSADPLKSESKGIRQ 590

  Fly   610 QYSSYLYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQ 674
            ....|:.|            |:.||..|...::.|::    :.|.|...:|  ||...:..  .:
Worm   591 IEGRYIQN------------EMFADFIGHEASWRAFM----KLDVKNEEVL--ETFKVIKL--RR 635

  Fly   675 LFF----IYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSG 735
            :||    :||    |.........|......||...|  |||...|..:|...|.||....||..
Worm   636 MFFNVQALYF----CRPPSGSTDWLSYQEHHQHYSFR--VNGAFKNMPQFALAFECASDDDMNPQ 694

  Fly   736 DKCLVY 741
            :||.::
Worm   695 NKCSMF 700

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	138/768 (18%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	139/769 (18%)
nep-9	NP_494531.2	M13	87..698	CDD:189000	140/767 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3590
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910