Protein Alignment Nepl13 and Ece2

DIOPT Version :10

• Sequence 1: NP_651096.1
• Gene: Nepl13 / 42699
• FlyBaseID: FBgn0039022
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_647454.2
• Gene: Ece2 / 107522
• MGIID: 1101356
• Length: 763
• Species: Mus musculus
• Alignment Length: 730
• Identity: 173/730 - (23%)
• Similarity: 306/730 - (41%)
• Gaps: 108/730 - (14%)

  Fly    55 KIATDVQKYMNLSADPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMET--KISEQLQQLLTQP 117
            ::|..:.:.::....||.||::::||.|       :|.:.|...:....|  .:.:|.|.:|...
Mouse    99 RVAGKILESLDRGVSPCQDFYQFSCGGW-------IRRNPLPNGRSRWNTFNSLWDQNQAILKHL 156

  Fly   118 LPPQHHPNGYSGASMTNVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQ 182
            |     .|....:|....||.|:||.||:..|.......:.|..::...||        |.....
Mouse   157 L-----ENTTFNSSSEAERKTRSFYLSCLQSERIEKLGAKPLRDLIDKIGG--------WNITGP 208

  Fly   183 WVQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYE 247
            |.:       :..:|:         |:.:.|.  |...|..|:.       ::.........:.:
Mouse   209 WDE-------DSFMDV---------LKAVAGT--YRATPFFTVY-------VSADSKSSNSNIIQ 248

  Fly   248 LVQQQVTENLRDWFGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSR 312
            :.|..:....||:: ::.....:.....:.:..||...:|.|. ....|:....::.:|..|...
Mouse   249 VDQSGLFLPSRDYY-LNRTANEKVLTAYLDYMVELGVLLGGQP-TSTREQMQQVLELEIQLANIT 311

  Fly   313 TGQERLRRQK---GGMTLTELTS-----EMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVR 369
            ..|::.|.::   ..|:::||.:     :....|.| :|..:.|....|..||  ..||::.|..
Mouse   312 VPQDQRRDEEKIYHKMSISELQALAPAVDWLEFLSF-LLSPLELGDSEPVVVY--GTEYLQQVSE 373

  Fly   370 TVKANNRITVGGYILY----VALNELNQPPEEAPSQ--------------RARQCVQVTQRLFPQ 416
            .:.......:..|:::    ...:.|:|..|.|..:              |.:.|:..|......
Mouse   374 LINRTEPSILNNYLIWNLVQKTTSSLDQRFETAQEKLLETLYGTKKSCTPRWQTCISNTDDALGF 438

  Fly   417 VLGEMFQRHVQRDNAKHDLDAVFNDVIKALEEQF-HVEWMDENDRRAARTRLSQY--RVSLPDY- 477
            .||.:|.:......:|...:.:.|::..|.||.. .:.||||..|.||:.:....  .:..||:
Mouse   439 ALGSLFVKATFDRQSKEIAEGMINEIRSAFEETLGDLVWMDEKTRLAAKEKADAIYDMIGFPDFI 503

  Fly   478 -QSLDLTDLQ--FQKSED-YWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQ 538
             :..:|.|:.  ::.||| :::.:.....:.:....:.|| ....:|...:....|.|...|.:.
Mouse   504 LEPKELDDVYDGYEVSEDSFFQNMLNLYNFSAKVMADQLR-KPPSRDQWSMTPQTVNAYYLPTKN 567

  Fly   539 MVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYR 601
            .::...|:||||:|.:.:||:|.:..:|..:...|..||||:|  ::........|...:::.::
Mouse   568 EIVFPAGILQAPFYAHNHPKALNFGGIGVVMGHELTHAFDDQGREYDKEGNLRPWWQNESLTAFQ 632

  Fly   602 NASECQRAQYSSYLYNEPGEFRNATR-LREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETL 665
            |.:.|...|||.|..|  ||..|..: |.|.|||..||..|:|||.|||.:...: :||.|
Mouse   633 NHTACMEEQYSQYQVN--GERLNGLQTLGENIADNGGLKAAYNAYKAWLRKHGEE-QPLPA---- 690

  Fly   666 SELNFTNTQLFFIYFAQTRCWAK----DNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGC 726
              :..||.||||:.|||..|..:    .::..:.|     .|:|.|:.|.|.||||.:|.|.|||
Mouse   691 --VGLTNHQLFFVGFAQVWCSVRTPESSHEGLVTD-----PHSPARFRVLGTLSNSRDFLRHFGC 748

  Fly   727 ALGTPMNSGDKCLVY 741
            .:|:|||.|..|.|:
Mouse   749 PVGSPMNPGQLCEVW 763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	M13	68..738	CDD:341056	170/712 (24%)
Ece2	NP_647454.2	M13	112..761	CDD:341056	170/713 (24%)