DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nepl13 and ecel1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_012818808.2	Gene:	ecel1 / 100496473	XenbaseID:	XB-GENE-989944	Length:	764	Species:	Xenopus tropicalis

Alignment Length:	797	Identity:	194/797 - (24%)
Similarity:	338/797 - (42%)	Gaps:	165/797 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LLFEIQLCDVTEAR--QNHMNRMQMSGNFPDSREEQLVRQKIATDVQKYMNLSADPCTDFFEYAC 79
            |:|.:.||.:....  ..::: |:......:..:|:....:.:..:...::.:..|||||:.:||
Frog    61 LVFAVGLCVILGCMLVLKYLS-MEQDVQCLEGCQERKAFMRASKFITNNIDPTISPCTDFYSFAC 124

  Fly    80 GQWGRYHKRQLRPDEL--STAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGASMTNVRKVRAFY 142
            |.|.|.|  .:..|:|  .|...:.|.. .|:|:.||.||:..:|     .|::   .|||:.|:
Frog   125 GGWLRRH--GIPEDKLIYGTIAAIGEQN-EEKLEHLLLQPVRRKH-----KGSA---ERKVKEFF 178

  Fly   143 ESCVAVEANASERRRFLMKILKDNGG--LRNVPNSNWQHNRQWVQTLGELRRNYGLDILLGLE-- 203
            :||:.:........|.::::::|.||  |...|.:.|..|....:|.|.........:.:.|:
Frog   179 KSCLNMRDIDRLGARPMLQVIEDCGGWDLPEDPRTQWDFNELLYKTQGVYSTAVFFSMTVSLDDK 243

  Fly   204 --------IDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQQVTENLRDW 260
                    ||.:..|:...|:|.|:.:      |....|         |.|::..|.:...|
Frog   244 NSSRYIIRIDQDGLTLPERTLYLGQDE------ESIKVL---------EAYKVFMQTILSLL--- 290

  Fly   261 FGMDTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQ-ERLRRQKGG 324
                                      |.:::||..||.   :..:.:.:.....: :.:||....
Frog   291 --------------------------GVENVQKKAEEI---LHLEQHLSNITISEFDDMRRDIST 326

  Fly   325 M----TLTELTSEMGNHLDFKMLVEVILESQYP--SQVYLRSPEYVKHVVRTVKANNRITVGGYI 383
            |    ||.:| .::..||::|.|:..|..:.:|  .:|.:.:.:|::.|...:::.....:..|:
Frog   327 MYNKVTLAQL-QQITPHLNWKNLLNRIFHTNFPEDEEVVVLATDYMQKVSEMIRSTPASVLHNYM 390

  Fly   384 LY---------------VALNELNQPPE--EAPSQRARQCVQVTQRLFPQVLGEMF--------- 422
            |:               .|::||::..|  |..::..:.|:....:.|...||.:|
Frog   391 LWRIVVVLSEHLSTPFRDAIHELSKEMEGSEKQAELTKVCLTQANKHFGMALGALFVEEYFSSSS 455

  Fly   423 QRHVQR--DNAKHDLDAVFNDVIKALEEQFHVEWMDENDRRAARTRLSQYRVSL--PDY----QS 479
            :..||:  :|.||.||       ..|||   ::|||...::|||.:|....|.:  ||.    :|
Frog   456 KAKVQQLVENIKHILD-------YRLEE---LDWMDTETKQAAREKLKHMMVMIGYPDVLLQPES 510

  Fly   480 LDLTDLQFQKSE-DYWRRLEIALKYRSHQQFEALRGNDFGQDAD---------GLDAFEVRAALS 534
            :| .:.:|:.:| .|::.:..:::|........:|     |:.|         .|:|:    .|.
Frog   511 MD-KEYEFEVNEKTYFKNILNSIRYSIKMAVRRIR-----QEVDKSAWLLPPQALNAY----YLP 565

  Fly   535 PRQQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEGWNNHPQATAQ----WNEV 595
            .:.|||... |:||...|:..:|:||.|..:|..:...|...:||  |.....|...    |.|.
Frog   566 NKNQMVFPA-GILQPTLYDPDFPQSLNYGGIGTIIGHELTHGYDD--WGGQYDANGNPIQWWTED 627

  Fly   596 TMSGYRNASECQRAQYSSY-LYNEPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPL 659
            :.|.:...:||....|.:: :||:  .....|.|.|.|||..||.||:.||..|:.....: ||
Frog   628 SYSKFLKKAECIVDLYENFTVYNQ--RVNGRTTLGENIADLGGLKLAYYAYQKWVRDNGPE-RP- 688

  Fly   660 LAKETLSELNFTNTQLFFIYFAQTRCWAKDNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREF 724
                 |..|.:|:.|||||.|||..|..:.:|...|..: ..:|.||.:.|.|.:|...||||.|
Frog   689 -----LPRLKYTHDQLFFIAFAQNWCIKRRSQSIYLQVL-TDKHAPEHYRVMGSVSQFEEFGRVF 747

  Fly   725 GCALGTPMNSGDKCLVY 741
            .|...:|||...||.|:
Frog   748 HCPRNSPMNPVHKCSVW 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	182/738 (25%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	185/739 (25%)
ecel1	XP_012818808.2	M13	113..762	CDD:341056	186/740 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020