DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ece2

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_002935189.1	Gene:	ece2 / 100488407	XenbaseID:	XB-GENE-1011916	Length:	766	Species:	Xenopus tropicalis

Alignment Length:	777	Identity:	189/777 - (24%)
Similarity:	320/777 - (41%)	Gaps:	119/777 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SAWLGFLL--ELLLLFEIQLCDVTEARQNHMNRMQMSGNFPDSREEQLVRQKIATDVQKYMNLSA 68
            ||.||.||  .|:.|...|:.|.:.:.......:.::|...||                 ::...
Frog    68 SAVLGVLLLGSLIALGVQQMTDRSRSLCLSEACVSVAGRILDS-----------------LDRGI 115

  Fly    69 DPCTDFFEYACGQWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNGYSGASMT 133
            |||.||::|:||.|.|   |...||..|.....  ..|.:|.|.:|...|     .|....:|..
Frog   116 DPCQDFYQYSCGGWMR---RNPLPDGRSRWNTF--NSIWDQNQAILKHIL-----ENATFNSSSE 170

  Fly   134 NVRKVRAFYESCVAVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQWVQTLGELRRNYGLDI 198
            ...|.:.||.||:..:.....|::.|..:::..||. |: :.||: ...::..|..:...|....
Frog   171 AEMKTQRFYLSCLKEQRIEELRQKPLTDLIEKIGGW-NI-SGNWR-GENFMSVLKTVSGTYRATP 232

  Fly   199 LLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYELVQQQVTENLRDWFGM 263
            ...:.:..:.::...|.|...:..| .:|:.......|...:|.|     ...|...::.:..|.
Frog   233 FFSVFVSADSKSSNSNIIQVDQSGL-FLPSRDYYLNKTANGKVLD-----AYLQYMVSVGELLGG 291

  Fly   264 DTGEAARFAGDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYGARSRTGQERLRRQKGGMTLT 328
            ..|........|:.||..|......||.::.||        :||..               ||::
Frog   292 SPGSVDMQMTQILEFETLLANLTVPQDERRDEE--------KIYNR---------------MTIS 333

  Fly   329 ELTS-----EMGNHLDFKMLVEVILESQYPSQVYLRSPEYVKHVVRTVKANNRITVGGYILYVAL 388
            ||.|     :..::|.| .|..:.|....|..||  ..||::.|...|...:.:.:..|:::..:
Frog   334 ELQSLAPAFDWMDYLTF-ALSPLDLNDTEPVVVY--GKEYLQQVSELVNNTDPMLLNNYLVWNLV 395

  Fly   389 NELNQP------------------PEEAPSQRARQCVQVTQRLFPQVLGEMFQRHVQRDNAKHDL 435
            .:::..                  .:::.:.|.:.|:..|.......||.:|.:.....|:|:..
Frog   396 QKMSSSLDSRFEKAQDKLLESLYGAKKSCTPRWQTCLSNTDDTLGFALGSLFVKSTFDKNSKNIA 460

  Fly   436 DAVFNDVIKALEEQF-HVEWMDENDRRAARTRLSQY--RVSLPDYQSLDLTDLQ-----FQKSED 492
            :.:.:::..|.|... .:.||||..||||:.:....  .:..||: .||..:|.     |:.|||
Frog   461 EQMISEIRDAFELTLGGLTWMDEKTRRAAKEKADAIYDMIGFPDF-ILDTKELDEVYDGFEVSED 524

  Fly   493 -YWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFEVRAALSPRQQMVLVGWGLLQAPYYNYYY 556
             :::.:.....:.:....|.|| ....::...:....|.|...|.:..::...|:||||:|...:
Frog   525 AFFQNMLNFYNFSAKLMAEQLR-KPPNREQWSMTPQTVNAYYLPNKNEIVFPAGILQAPFYAPTH 588

  Fly   557 PKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSGYRNASECQRAQYSSYLYNEP 619
            ||:|.:..:|..:...|..||||:|  ::........|...::..::|.:||...||:||..|
Frog   589 PKALNFGGIGVVMGHELTHAFDDQGREYDEDGNLRPWWQNSSLEAFKNRTECMVNQYNSYTVN-- 651

  Fly   620 GEFRNATR-LREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKETLSELNFTNTQLFFIYFAQT 683
            ||..|..: |.|.|||..||..|::||.:||.:...       ::.|..:..||.||||:.|||.
Frog   652 GERVNGRQTLGENIADNGGLKAAYHAYKSWLVKHGE-------EKQLPGVGLTNNQLFFVGFAQV 709

  Fly   684 RCWAK----DNQDAILDSMPLMQHTPERWDVNGPLSNSAEFGREFGCALGTPMNSGDKCLVY 741
            .|..:    .::..:.|     .|:|.::.|.|.||||.:|...|.|..|||||.|..|.|:
Frog   710 WCSVRTPESSHEGLVTD-----PHSPAKFRVIGTLSNSKDFAEHFNCPKGTPMNPGKHCDVW 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	170/707 (24%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	174/708 (25%)
ece2	XP_002935189.1	M13	115..763	CDD:341056	174/708 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11733
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.020