DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nepl13 and ece1

DIOPT Version :9

Sequence 1:	NP_651096.1	Gene:	Nepl13 / 42699	FlyBaseID:	FBgn0039022	Length:	741	Species:	Drosophila melanogaster
Sequence 2:	XP_031762312.1	Gene:	ece1 / 100485607	XenbaseID:	XB-GENE-1014218	Length:	782	Species:	Xenopus tropicalis

Alignment Length:	797	Identity:	179/797 - (22%)
Similarity:	312/797 - (39%)	Gaps:	163/797 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LLELLLLFEIQLCDVTEARQNHMNRMQMSGNFPDSREEQLVRQ--KIATDVQKYMNLSADPCTDF 74
            ||.|::|..:.|         .|..:.:|..:.:|....|...  .:.:.:.:.::.|||||.||
Frog    82 LLVLVVLLSLGL---------FMCLLALSLQYRNSHRVCLSESCISVTSSILRSLDRSADPCQDF 137

  Fly    75 FEYACG-------------QWGRYHKRQLRPDELSTAQQLMETKISEQLQQLLTQPLPPQHHPNG 126
            ::|:||             :||.::  :|.....:|.:.|:|....|
Frog   138 YQYSCGGWIKGNPVPDGHSRWGTFN--ELWEHNQATMKHLLENSTIE------------------ 182

  Fly   127 YSGASMTNVRKVRAFYESCV----AVEANASERRRFLMKILKDNGGLRNVPNSNWQHNRQW---- 183
               .:.|..||.:.::::|:    ..|..|...:..:.|:    ||        |.....|
Frog   183 ---TNSTAERKAQRYFQACMNETKIEELGAKPLQDLIQKL----GG--------WAITGPWDRDN 232

  Fly   184 -VQTLGELRRNYGLDILLGLEIDLNLQTMKGNTIYFGEPKLTIIPAEHCNALATRGAQVRDEVYE 247
             .:||..:..:|.......:.:..:.:....|.|...:..|. :|:.......|...:|......
Frog   233 FQETLQLVTAHYRTSPFFSVFVSADSKNSNSNVIQIDQSGLG-LPSREFYLNKTENEKVLTGYLN 296

  Fly   248 LVQQQVTENLRDWFGMDTGEAARFA----GDIIRFEFELCKQMGEQDIQKPEEEFPPAIQAQIYG 308
            .:.|         .|:..|.|....    .:|:.||..|.      :|..|:|:
Frog   297 FMIQ---------LGVLLGGAENSTREQMQEILDFETTLA------NITIPQEK----------- 335

  Fly   309 ARSRTGQERLRRQKGGMTLTELTSEMGNHLDFKMLV--EVILESQYPSQVYLRSPEYVKHVVRTV 371
               |..:|::..:.....|.:|...: :.:.|...|  .|.:....|..||.:  ||:..|...:
Frog   336 ---RRDEEQIYHKMAAGELKDLVPAV-DWMPFLQTVFYPVAINESEPVVVYAK--EYLVAVSGLI 394

  Fly   372 KANNRITVGGYILY----VALNELNQPPEEAPSQ--------------RARQCVQVTQRLFPQVL 418
            .:.::..:..|:::    .|.:.|:|..::|..:              |.:.|:..|.......|
Frog   395 NSTDKRILNNYMMWNLVRKASSFLDQRFQDAEEKLMEVMYGTKKTCLPRWKFCISDTDNNLGFAL 459

  Fly   419 GEMFQRHVQRDNAKHDLDAVFNDVIKALEEQFH-VEWMDENDRRAARTR------LSQYRVSLPD 476
            |.||.:....:|:|.....:..::..|.||... :.|||:..|||||.:      :..|...:.|
Frog   460 GAMFVKATFAENSKLQALKMIKEIKAAFEENLSTLTWMDDETRRAAREKAEAIYDMIGYPNFIMD 524

  Fly   477 YQSLDLTDLQFQKSEDYWRRLEIALKYRSHQQFEALRGNDFGQDADGLDAFE-----VRAALSPR 536
            .:.||.....:..:.|::  .|..:::   ..|.|....|..:.|...|.:.     |.|..||.
Frog   525 PKELDKVFNDYNVTSDFY--FENGMRF---YNFSARVTADQLRKAPSKDQWSMTPPTVNAYYSPT 584

  Fly   537 QQMVLVGWGLLQAPYYNYYYPKSLKYALLGHRLASALVQAFDDEG--WNNHPQATAQWNEVTMSG 599
            :..::...|:||||:|....|.:|.:..:|..:...|..||||:|  ::........|...::..
Frog   585 KNEIVFPAGILQAPFYTSSSPTALNFGGIGVVMGHELTHAFDDQGREYDKDGNLRPWWKNASVEA 649

  Fly   600 YRNASECQRAQYSSYLYN-EPGEFRNATRLREIIADGSGLNLAFNAYLAWLEQQDHKLRPLLAKE 663
            ::..:||...||.:|..| ||...|..  |.|.|||..||..|:.||..|:.:..       |::
Frog   650 FKKQTECITEQYGNYTVNGEPVNGRQT--LGENIADNGGLKAAYRAYKNWVRKNG-------AEQ 705

  Fly   664 TLSELNFTNTQLFFIYFAQTRCWAKDNQDA----ILDSMPLMQHTPERWDVNGPLSNSAEFGREF 724
            .|..|..:|.||||:.|||..|..:.::.:    |.|     .|:|.|:.|.|.:|||.||...|
Frog   706 LLPSLGLSNDQLFFVGFAQVWCSVRTSESSHEGLITD-----PHSPSRFRVIGSVSNSQEFAEHF 765

  Fly   725 GCALGTPMNSGDKCLVY 741
            .|..|:|||..:||.|:
Frog   766 RCPPGSPMNPRNKCEVW 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nepl13	NP_651096.1	PepO	63..732	CDD:226118	164/733 (22%)
Nepl13	NP_651096.1	M13	68..738	CDD:189000	166/734 (23%)
ece1	XP_031762312.1	M13	131..780	CDD:341056	167/735 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D282463at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010