DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG31139 and POGLUT1

DIOPT Version :10

Sequence 1:NP_732797.1 Gene:CG31139 / 42698 FlyBaseID:FBgn0051139 Length:397 Species:Drosophila melanogaster
Sequence 2:NP_689518.1 Gene:POGLUT1 / 56983 HGNCID:22954 Length:392 Species:Homo sapiens


Alignment Length:295 Identity:59/295 - (20%)
Similarity:111/295 - (37%) Gaps:106/295 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 NSGVRLDYYQRIV----HRLIMRHQQPVTGLFPASPQTQHA-WIRDNVYCILAVWG---LSMAYK 62
            ::|.:.:.::|::    |..|::   |...:|..|....|| |:|      ||..|   |:| ::
Human   139 SAGDKWNRHRRMLTPAFHFNILK---PYVKIFNDSTNIMHAKWLR------LASGGSTRLNM-FE 193

  Fly    63 KIADQDEDRAKAYELEQCCVKLMRGLLMAMMNQKEKVERFKTSQNPLDSLHAKYSSRNGQIVVGD 127
            .|:....|     .|::|       :.....|.:||..::..:...|.:|..|   ||.|::   
Human   194 NISLMTLD-----TLQKC-------VFSFNSNCQEKPSQYIAAILELSTLAVK---RNEQLL--- 240

  Fly   128 SEWGHLQIDAISLYLLILAQMTASGLQIVFSLDEVAFIQNLVFYIESAYCIPDYG---IWE-RGD 188
                 :.:|       :|.::|..|::               || ::...:.|:.   |.| |..
Human   241 -----MHVD-------LLYRLTPDGMR---------------FY-KACRLVHDFTDAVIQERRRT 277

  Fly   189 KSNHGQPELNASSIGMAKAALEAMN-----------------------ELDLFGARG------GS 224
            ...||     ...|..|||..:.::                       |.|.|..||      |.
Human   278 LLKHG-----GDDIIKAKAKSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFRGHDTTASGL 337

  Fly   225 GSVIHVLA---DEAHKCQAVLQSMLPRESNSKELD 256
            ..:::.||   :...:|:..:|.:| |:.:.||::
Human   338 SWILYNLARHPEHQERCRQEVQELL-RDRDPKEIE 371

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG31139NP_732797.1 Glyco_transf_90 61..397 CDD:310354 43/232 (19%)
POGLUT1NP_689518.1 Glyco_transf_90 49..388 CDD:310354 59/295 (20%)
Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates. /evidence=ECO:0000269|PubMed:28775322 103..107
Interaction with the consensus sequence C-X-S-X-[PA]-C in peptide substrates. /evidence=ECO:0000269|PubMed:28775322 172..178 2/5 (40%)
Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138 389..392
Blue background indicates that the domain is not in the aligned region.

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