Protein Alignment CG17141 and NOA1

DIOPT Version :10

• Sequence 1: NP_651094.2
• Gene: CG17141 / 42697
• FlyBaseID: FBgn0039020
• Length: 323
• Species: Drosophila melanogaster
• Sequence 2: NP_115689.1
• Gene: NOA1 / 84273
• HGNCID: 28473
• Length: 698
• Species: Homo sapiens
• Alignment Length: 882
• Identity: 165/882 - (18%)
• Similarity: 293/882 - (33%)
• Gaps: 273/882 - (30%)

  Fly   346 QAVAEYSQKLEDILVKTEEGMKLIPELYAVPEKAVAAEYQAPGSQQRVVVGRCPFLWGQSLYILG 410
            ||..::.|:   .|:|.::..:..|:....|.:.....||....||:.......|   |:::...
Human   458 QATPQHQQQ---HLLKQQQQQQQQPQQPTAPPQPAGTFYQQQQQQQQQQAQTQQF---QAVHPAA 516

  Fly   411 KLLQEGFLAVGELDPLNRRLGA----QKKPDVVVQVVILAEDNDIRDKLA--------------- 456
            :........||......::|..    |::.....|..::|:...::.|.|
Human   517 QQPVTAQFPVGSQGGAQQQLMQNFYHQQQQQQQQQQQLMAQQAALQQKTAVVVPQSQAQPATAPQ 581

  Fly   457 -----EHGIQVQTIADVAPIEVQPARVLSHLYTYLGRNKKLGL----SGRKSRDVGILSTSKLYS 512
                 |.|||       ||:..||....:...|..|  :|:|.    |..|::..|
Human   582 AAAAQEPGIQ-------APVRQQPKVQTTPPPTIQG--QKVGSLTPPSSPKTQRAG--------- 628

  Fly   513 LKDRIFAFTPQFSDVNRFYI----ASDNELMIDLLKGE--INFLKSAWQNLLGRPLLTLVLKTVH 571
             ..||      .|||....:    ||.:..::.....|  :|..|||.....|.|
Human   629 -HRRI------LSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSP---------- 676

  Fly   572 LDNNKVPLAMIQTMKKLKSGYISGTRVILGNLGDFINTSAIT-------DLSFLGSQEDGYPDKL 629
                       :|.::..|....|:   ..|..|..|.|.:|       |.:.||  |...|:||
Human   677 -----------RTSQQNVSNASEGS---TWNPFDDDNFSKLTAEELLNKDFAKLG--EGKLPEKL 725

  Fly   630 NPAVQAYL--------DEHLLRSFSHRASTTSIRSSG---------LRPKNLRRRMSVKGAIKKT 677
            ..:.::.:        |.....|||  |.|...|..|         |...:....:.|..|..|.
Human   726 GGSAESLIPGFQPTQGDAFTTPSFS--AGTAEKRKGGQAVDSGIPLLSVSDPFIPLQVPDAPDKA 788

  Fly   678 RSINVDSETLGMEGNVTERRLSHVTPQWLEPNQTTVGAAGAAGAGTGAATTGPSGGSPTSRDPSP 742
             .:.|:|...|:|..|.:|.          |:||.            :.|:..:|   ..|||||
Human   789 -DVAVESLIPGLEPPVAQRL----------PSQTE------------SVTSNRTG---LQRDPSP 827

  Fly   743 NTQAQQQQQQQQQQPRYGTERVSLDDDGKKLHIQTSATAAMPKIHIQPLPRHRPTTETNFENTEV 807
            ......:..::..    ||:.:.|..|    ..:...|.....:....|.|..|::.::|.::
Human   828 CPVITVEHFKESM----GTKGLPLYPD----PCRAPGTKTQNTLASDSLAREGPSSNSSFHSS-- 882

  Fly   808 EELIAMLRETENLEEQGDIL-----QHLVDTQGLDFNTGMLEE--GRVVTVRGLLKGLYEKA--C 863
                    |.|..:.:||:|     :.|::::..|.|...|:|  |..        .|:.::  |
Human   883 --------EEEGTDLEGDMLDCSGSRPLLESEEEDENCRPLQEKLGEA--------ALFSESGVC 931

  Fly   864 QQKMWGLVRHTAGMLGKRVEDL---AKAVTDLLVRQKQVTVGMPPNSEHTITAPLPEMELRAVIH 925
            .:.      ...|..||:.:.|   .:|..||         |.|   :...|||.....:.|
Human   932 TEP------EERGQGGKKSQFLPINQRASDDL---------GEP---DVFATAPFRSSLVPA--- 975

  Fly   926 EAYGDD---------ESTAMLSQELLVYLAMFIRTEPQLFHEMLRLRVGLIIQVMAKELSRTLNC 981
                ||         .|...::...:..:.:|.|..   |.:...:...|.:|..:::|....|.
Human   976 ----DDVDIFSKAPFVSKGSVAPSQMDEVDVFSRAP---FTKKRSMEEFLAVQGSSQDLPMQANL 1033

  Fly   982 DGEQASEHLLNLSPFEMKNLLHHILSGKEFAINSVARGNISIV--SCKSSRVSKKSQIG------ 1038
              .|::|     .|         :|:|::.||.:.|:....:.  :.::...|...|:.
Human  1034 --SQSNE-----GP---------LLAGRDRAIYTPAQAQYPMTGFAPQAGLPSHSVQVADHFDGN 1082

  Fly  1039 --IGEPEAAEGSLIDDRQGQWLRRRRLDG----------ALNRVPRDFYPR-----------VWT 1080
              .|.|.::.|..:|..:|...::....|          ||::..|.:.|.           .:.
Human  1083 SPRGSPMSSGGHPVDRNRGLQPQKEAFSGPAAGKPFHPQALSKYSRHYSPEDELSAEAQPIAAYK 1147

  Fly  1081 VLERCSGLAIEGRILPQSLTQEMTPNELKFALEVETA 1117
            ::.:.:...:.|.:...||:...|        |:.||
Human  1148 IVSQSNKQLLAGSVSVTSLSSRTT--------ELATA 1176

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG17141	NP_651094.2	GTPase_YlqF	20..317	CDD:274669
NOA1	NP_115689.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..66
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..134
		GTPase_YqeH	141..660	CDD:213834	43/232 (19%)
		YqeH	179..394	CDD:206748
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	279..306