DRSC/TRiP Functional Genomics Resources

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Protein Alignment HP1c and CDYL

DIOPT Version :10

Sequence 1:NP_651093.1 Gene:HP1c / 42696 FlyBaseID:FBgn0039019 Length:237 Species:Drosophila melanogaster
Sequence 2:NP_001355054.1 Gene:CDYL / 9425 HGNCID:1811 Length:598 Species:Homo sapiens


Alignment Length:285 Identity:66/285 - (23%)
Similarity:97/285 - (34%) Gaps:123/285 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PNFVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEE---NCD-------------------- 47
            |...||||:|||...:||.||.::|:||.|.|:|||||:   ||:                    
Human    59 PALQVERIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHTEKQKESTLT 123

  Fly    48 -----CPNLIQKFEESRAKSKKRGEKKPKCEEI---------------QKLR-------GYERGL 85
                 .||..:| :.||:.:....:..||...|               ||.|       ...:.:
Human   124 RTNRTSPNNARK-QISRSTNSNFSKTSPKALVIGKDHESKNSQLFAASQKFRKNTAPSLSSRKNM 187

  Fly    86 ELAEIVGATDVTGDIKYLVRWQFCDEFDLVPSAQIVEKDPQMLIDYFQKMAPYSRHIAMRMKGVP 150
            :||:        ..||.           |||.:.:..:   ..:|.||..:             |
Human   188 DLAK--------SGIKI-----------LVPKSPVKSR---TAVDGFQSES-------------P 217

  Fly   151 EELRLAASRTSYPHISSAPVE------VPPEVDQSAELAGHLG--------GIAPQVDQ-APQHH 200
            |:|              .|||      |.|||.....:...||        |..|::.. .||..
Human   218 EKL--------------DPVEQGQEDTVAPEVAAEKPVGALLGPGAERARMGSRPRIHPLVPQVP 268

  Fly   201 APMDLANDTDDLASVSYSIPVPGVG 225
            .|:        .|:::..:.|.|.|
Human   269 GPV--------TAAMATGLAVNGKG 285

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HP1cNP_651093.1 CD_CSD 8..55 CDD:475127 25/74 (34%)
CSD 85..135 CDD:349275 10/49 (20%)
CDYLNP_001355054.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..76 8/16 (50%)
Interaction with EZH2. /evidence=ECO:0000269|PubMed:22009739 61..309 65/283 (23%)
CD_CDY 62..111 CDD:349284 23/48 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 112..149 5/37 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..226 9/51 (18%)
crotonase-like 344..540 CDD:119339
Acetyl-CoA-binding domain. /evidence=ECO:0000255 362..594
Blue background indicates that the domain is not in the aligned region.

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