DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1c and Mphosph8

DIOPT Version :9

Sequence 1:	NP_651093.1	Gene:	HP1c / 42696	FlyBaseID:	FBgn0039019	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_001347001.1	Gene:	Mphosph8 / 75339	MGIID:	1922589	Length:	870	Species:	Mus musculus

Alignment Length:	181	Identity:	46/181 - (25%)
Similarity:	79/181 - (43%)	Gaps:	43/181 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EPNFVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEENC-DCPNLIQKFEESRAKSKKRGEK 68
            |..|.||||:|.:... ||..|.::|:||||.|:|||||.:. ||..::.:|.:..|::|.:..:
Mouse    56 EDVFEVERILDMKCEG-GKNLYKVRWKGYTSEDDTWEPEVHLEDCKEVLLEFRKKLAENKAKAVR 119

  Fly    69 KPKCEEIQKLRGYERGLELAEIVGATDVTGDIKYLVRWQFCDEFDLVPSAQIVEKDPQMLIDYFQ 133
            |    :||:|   ....::.|....:|...|.|.          |:.|..:
Mouse   120 K----DIQRL---SLNNDIFEADSDSDQQSDTKE----------DISPRKK-------------- 153

  Fly   134 KMAPYSRHIAMRMKGVPEELRLAASRTSYPHISSAPVEVPPEVDQSAELAG 184
                 .:.|..:.:..||:||  ..||....:..   :...|::.::|:.|
Mouse   154 -----KKKIKCKEETSPEDLR--KKRTKMGKLKD---KFKTELESTSEIIG 194

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1c	NP_651093.1	Chromo	9..58	CDD:278797	22/49 (45%)
HP1c	NP_651093.1	Chromo_shadow	89..134	CDD:279701	6/44 (14%)
Mphosph8	NP_001347001.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..55
		CHROMO	58..109	CDD:214605	23/51 (45%)
		Histone H3K9me3 binding. /evidence=ECO:0000250\|UniProtKB:Q99549	80..87		5/6 (83%)
		Neuromodulin_N	<97..482	CDD:331332	25/139 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	129..175		13/76 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..234
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..300
		ANK	605..729	CDD:238125
		ANK 1	610..639
		ANK repeat	613..641	CDD:293786
		ANK repeat	643..674	CDD:293786
		ANK 2	643..672
		ANK repeat	676..705	CDD:293786
		ANK 3	676..705
		ANK 4	709..738
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1628171at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820