Protein Alignment HP1c and Cbx8

DIOPT Version :10

• Sequence 1: NP_651093.1
• Gene: HP1c / 42696
• FlyBaseID: FBgn0039019
• Length: 237
• Species: Drosophila melanogaster
• Sequence 2: NP_038954.1
• Gene: Cbx8 / 30951
• MGIID: 1353589
• Length: 362
• Species: Mus musculus
• Alignment Length: 284
• Identity: 71/284 - (25%)
• Similarity: 103/284 - (36%)
• Gaps: 104/284 - (36%)

  Fly     8 FVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEENCDCPNLIQKFEESRAK-----SKKRGE 67
            |..|.::.:|| .:|::||.:||:|::...:|||||||.....|:..|||...:     .||||.
Mouse    11 FAAEALLKRRI-RKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEEREREMELYGPKKRGP 74

  Fly    68 KKP----KCEEIQKLRGYE------RGLELAEIVGATDVTGDIKYLVRWQFCDEFDLVPSAQIVE 122
            |..    |.:...|.:.||      ||:.             |.|             |.
Mouse    75 KPKTFLLKAQAKAKAKTYEFRSDSTRGIR-------------IPY-------------PG----- 108

  Fly   123 KDPQMLIDYFQKMAPYSR-HIAMRMKGVP------------------EELRLAASRT----SYPH 164
            :.|       |.:|..|| ...:|..|:|                  .|.....||.    |.|.
Mouse   109 RSP-------QDLASTSRAREGLRNTGLPPPGSSTSTCRADPPRDRDRERDRGTSRVDDKPSSPG 166

  Fly   165 ISS-----APVEVP------PEVDQSAELAGHLGGIAPQVDQA-------PQHHAPMDLANDTD- 210
            .||     .|.:.|      |..:.||.|..:|.|  .::|:.       |..|:.:.||...|
Mouse   167 DSSKKRGPKPRKEPLDPSQRPLGEPSAGLGEYLKG--RKLDETSSGTGKFPAGHSVIQLARRQDS 229

  Fly   211 DLASVSYSIPVPGVGD----IAID 230
            ||  |.|.:..|...:    :|:|
Mouse   230 DL--VQYGVTSPSSAEASSKLAVD 251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HP1c	NP_651093.1	CD_CSD	8..55	CDD:475127	18/46 (39%)
		CSD	85..135	CDD:349275	5/49 (10%)
Cbx8	NP_038954.1	CD_polycomb_like	11..59	CDD:349277	19/48 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	90..197		28/144 (19%)
		CBX7_C	322..354	CDD:465385