DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1c and chp1

DIOPT Version :9

Sequence 1:	NP_651093.1	Gene:	HP1c / 42696	FlyBaseID:	FBgn0039019	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_593666.1	Gene:	chp1 / 2542239	PomBaseID:	SPAC18G6.02c	Length:	960	Species:	Schizosaccharomyces pombe

Alignment Length:	318	Identity:	74/318 - (23%)
Similarity:	117/318 - (36%)	Gaps:	120/318 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEEN----------------CDCPNLIQKF- 55
            :.||.|:..|:...|..||||||.||...|||||||:|                .....|::.|
pombe    22 YEVEDILADRVNKNGINEYYIKWAGYDWYDNTWEPEQNLFGAEKVLKKWKKRKKLIAKGLLEPFD 86

  Fly    56 -EESRAKSKKRGEKKPKCEEIQKLRGYERGLELAEIVGATDVTGDIKYLVRWQFCDEFDLV---P 116
             |::.||..|| ||     ||.:.:..:|..||      |.::..:|        ::|..:   |
pombe    87 AEDNEAKKMKR-EK-----EILRQQRQKRKSEL------TQLSQKVK--------EKFKKMRKKP 131

  Fly   117 SAQIV--------EKDPQMLIDYFQKMAPYSRHIAMRMKGVPEELRLAASRTS------------ 161
            :.:||        |.|..|..|.|::.:         |:|..:|..| ..:||
pombe   132 ARRIVTIANDEEEEDDQTMDEDAFERKS---------MQGELKERNL-TDKTSTLSTSFGETSPD 186

  Fly   162 --------YPHISSA------------PVE---------VPPEVDQSA---ELAGHLGGIAPQVD 194
                    :|.::.:            |::         :|.:.|.|.   :.:.:|......|:
pombe   187 VNPFYLSEWPTVTDSILLSKSLSSDAIPLKNGEIKSTMLMPSDSDNSVPGIQNSNNLENTGAFVE 251

  Fly   195 QA--PQ---------HHAPMDLA------NDTDDLASVSYSIPVPGVGDIAIDVPMAE 235
            .|  ||         |.:|:.|:      ||..:....|.|.|:|....|..:.|..|
pombe   252 NANSPQSNTPLSTFRHSSPLSLSPVITSDNDVANSLFFSNSTPLPSSLKIKKEAPKLE 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1c	NP_651093.1	Chromo	9..58	CDD:278797	24/66 (36%)
HP1c	NP_651093.1	Chromo_shadow	89..134	CDD:279701	11/55 (20%)
chp1	NP_593666.1	CHROMO	21..>64	CDD:214605	21/41 (51%)
		RRM	224..>371	CDD:223796	20/86 (23%)
		RRM_SF	313..373	CDD:240668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	50	1.000	Domainoid score	I3374
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000191
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22812
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R201
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.030