Protein Alignment HP1c and CBX5

DIOPT Version :10

• Sequence 1: NP_651093.1
• Gene: HP1c / 42696
• FlyBaseID: FBgn0039019
• Length: 237
• Species: Drosophila melanogaster
• Sequence 2: NP_036249.1
• Gene: CBX5 / 23468
• HGNCID: 1555
• Length: 191
• Species: Homo sapiens
• Alignment Length: 157
• Identity: 56/157 - (35%)
• Similarity: 94/157 - (59%)
• Gaps: 26/157 - (16%)

  Fly     3 KNEPNFVVERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEENCDCPNLIQKFEESRAKSKKRGE 67
            ::|..:|||:::|:|:. :|:|||.:||:|::...||||||:|.|||.||.:|.:...|.|:...
Human    15 EDEEEYVVEKVLDRRVV-KGQVEYLLKWKGFSEEHNTWEPEKNLDCPELISEFMKKYKKMKEGEN 78

  Fly    68 KKPK---------------CEEIQK----------LRGYERGLELAEIVGATDVTGDIKYLVRWQ 107
            .||:               .::|:.          .||:|||||..:|:||||..||:.:|::|:
Human    79 NKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERGLEPEKIIGATDSCGDLMFLMKWK 143

  Fly   108 FCDEFDLVPSAQIVEKDPQMLIDYFQK 134
            ..||.|||.:.:...|.||::|.::::
Human   144 DTDEADLVLAKEANVKCPQIVIAFYEE 170

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HP1c	NP_651093.1	CD_CSD	8..55	CDD:475127	24/46 (52%)
		CSD	85..135	CDD:349275	20/50 (40%)
CBX5	NP_036249.1	CD_HP1alpha_Cbx5	19..68	CDD:349298	25/49 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	70..117		6/46 (13%)
		CSD_HP1alpha_Cbx5	116..173	CDD:349302	24/55 (44%)