DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HP1c and Cdyl

DIOPT Version :9

Sequence 1:	NP_651093.1	Gene:	HP1c / 42696	FlyBaseID:	FBgn0039019	Length:	237	Species:	Drosophila melanogaster
Sequence 2:	NP_034011.1	Gene:	Cdyl / 12593	MGIID:	1339956	Length:	593	Species:	Mus musculus

Alignment Length:	196	Identity:	53/196 - (27%)
Similarity:	77/196 - (39%)	Gaps:	35/196 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VERIMDKRITSEGKVEYYIKWRGYTSADNTWEPEEN-CDCPNLIQKFEESRAKSKKRG------E 67
            ||.|:|||...:||.||.::|:||.|.|:|||||:: .:|...|..|.....:.:|.|      .
Mouse    58 VESIVDKRKNKKGKTEYLVRWKGYDSEDDTWEPEQHLVNCEEYIHDFNRRHNERQKEGSLARASR 122

  Fly    68 KKPKCEEIQKLRGYERGL----ELAEIVGATDVTGDIKYLVRWQFCDEFDLVPSAQIV-EKDPQM 127
            ..|.....|..|.....|    ..|.:||....:...:.|...|   :|...|:..:. .|:..:
Mouse   123 ASPSNARKQISRSTHSTLSKTNSKALVVGKDHESKSSQLLAASQ---KFRKNPAPSLANRKNMDL 184

  Fly   128 LIDYFQKMAPYSRHIAMRMKGVPEELRLAASRTSYPHISSAPVEVPPEVDQSAELAGHLGGIAPQ 192
            .....:.:.|.|     .:||          |||.........|....|||.||     ..:||:
Mouse   185 AKSGIKILVPKS-----PVKG----------RTSVDGFQGESPEKLDPVDQGAE-----DTVAPE 229

  Fly   193 V 193
            |
Mouse   230 V 230

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HP1c	NP_651093.1	Chromo	9..58	CDD:278797	23/48 (48%)
HP1c	NP_651093.1	Chromo_shadow	89..134	CDD:279701	7/45 (16%)
Cdyl	NP_034011.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30
		CHROMO	55..109	CDD:214605	23/50 (46%)
		Interaction with EZH2. /evidence=ECO:0000250\|UniProtKB:Q9Y232	56..304		53/196 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..158		9/47 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..223		8/32 (25%)
		crotonase-like	339..535	CDD:119339
		Acetyl-CoA-binding domain. /evidence=ECO:0000255	357..589
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1911
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R201
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840