Protein Alignment vret and tdrd5

DIOPT Version :10

• Sequence 1: NP_651092.1
• Gene: vret / 42695
• FlyBaseID: FBgn0263143
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001038315.1
• Gene: tdrd5 / 557999
• ZFINID: ZDB-GENE-050208-502
• Length: 905
• Species: Danio rerio
• Alignment Length: 754
• Identity: 125/754 - (16%)
• Similarity: 237/754 - (31%)
• Gaps: 273/754 - (36%)

  Fly    21 YDQVGN---RYTNESGQKLIMEAPLPPKDEKEQRATRQAKYPYLVV--PKSSPYVTE-------- 72
            |...||   :...:...|.|.|.....:|.|.:...|:.|..|..:  |:..|.:..
Zfish    67 YQLDGNIILKAIGDDTTKGIEELVSKQRDHKPKPNNRKGKPGYFNISYPRLQPVILPRRGQAKPA 131

  Fly    73 ---------KMLINFFGRALIKEMEFRRLSR-------VYFVYFENIASLETA-------QQRVQ 114
                     |.|:: .|...:.|:|.|.:::       ..:.:|.....|..|       |.|..
Zfish   132 LPAHLRSQLKQLLS-HGPVRLSELESRYVAQFGKPLNVTQYGFFSISEMLSAAMDFIIMQQSRTG 195

  Fly   115 RYPNLIKCITGRPQKEREITSDPVTSTEPMP-----TPGPAISATERTPVNHNREVPISTGGQNH 174
            ....|...:|.:.|.|..:....:.||.|..     :| .|.|..||.|     ||.:.....:.
Zfish   196 SQLLLRSAVTPQNQPENLMRRFSMQSTSPKQRLAGFSP-KASSLPERRP-----EVSLDPSSVSK 254

  Fly   175 PEFFRPPLVTKDDYKRGSLLATNDPIQRYLNVKYEFALERHDIYKLKDETRIPQVVLHFRSGRTI 239
            ||                            .||.|.:.| ..::||::|.|
Zfish   255 PE----------------------------PVKEEQSFE-ETVFKLEEELR-------------- 276

  Fly   240 PLSTVAVTEEDKTKSLLEDGVSKCVVCQNWTDTFCKLCKMPFCNASCFADVAEQHKQACGKGEIL 304
                         :.:||.|.:                          ..|:::.|:
Zfish   277 -------------QQILEKGTA--------------------------GTVSQELKE-------- 294

  Fly   305 NLDEKVGRKYPKPGLPPSGSKVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVM-MLGKDASKLQ 368
                                |:|....|..|           .|:.:.:.||.. |.|::....|
Zfish   295 --------------------KLRKVVAENGN-----------GISIHNLPTEYQRMHGEELPVSQ 328

  Fly   369 STPVCGQIVLYKFEGHMSRAMVL--NVDNIKEIYVVFIDFGSVEVTQLERLYECSSYLA---GLT 428
                ||.:.:.:..|.:|..:.:  ..|..:..::| ::|..:: ||     .|...|:   |.|
Zfish   329 ----CGFLSVTEMVGALSDTLAIQRGTDESESHWMV-VEFKPID-TQ-----PCEPELSPGDGTT 382

  Fly   429 CYPVAVKLRGVPRRFVGPNIREVMYELDQSLVFNIKYSSREYDTSKGMQVVVMTEIDI---NRSL 490
            ..|..                |:.....::..|:...|:.|::.::.:.....::.::   |:::
Zfish   383 SSPTG----------------ELQNPSSRAFYFSCPESAWEHEETEPLTDSQESDAELRVANKTI 431

  Fly   491 NRLFKTILTPVEPSVSDLGYKEDCLPYIPLHCGK----------NINVVVMDNTFIQCGFIYCTS 545
            :::..  |.| |..||    :...:|...:.|.|          .:..|:::.|.....|.
Zfish   432 HQMVN--LFP-ELMVS----RVSAVPLDAVRCQKLKPPVHRKERELLPVLVEQTESPSYFY---- 485

  Fly   546 IDLAYEVTKMQRDIQEYGEKIAKCATYAPPINE--------------LCIAKYEGKWRRGLSVEL 596
              :.:...|..|.::....::..|.:| |.:.|              .|:|..:..:.|.:..|:
Zfish   486 --IRFSQNKEARALENMMIEMRSCYSY-PDVAERYRLPDAYVRPGQVCCVAPRDMWFYRVVIHEV 547

  Fly   597 VGDGYPSILFIDYGNIVPTHVTDIRPYPPQFI------FPIMTTQLDLIGVPEKPTDEQIKWLDK 655
            ..:....:.::|||:|     |.:..:..:|:      .|.......|.||  :|       :..
Zfish   548 FSETEVKVYYVDYGDI-----TKVERHSLRFLKACYADLPAQAVPAMLAGV--RP-------ITN 598

  Fly   656 NYPIGSVI----TCSEITFDEETNSYSTRIEKLQEFLSL 690
            .:|..:|.    .|.|.|.....:||.      ::||.|
Zfish   599 IWPASAVSCFQRLCCERTLVAGVHSYQ------EDFLLL 631

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vret	NP_651092.1	TUDOR	322..438	CDD:425754	24/121 (20%)
		Tudor_vreteno-like_rpt1	371..424	CDD:410515	10/54 (19%)
		TUDOR	524..640	CDD:425754	22/145 (15%)
		Tudor_vreteno-like_rpt2	576..631	CDD:410516	11/74 (15%)
tdrd5	NP_001038315.1	LOTUS_1_TDRD5	3..97	CDD:193599	7/29 (24%)
		LOTUS_2_TDRD5	133..202	CDD:193589	12/69 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..264		16/78 (21%)
		LOTUS_3_TDRD5	289..364	CDD:193590	17/118 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	368..393		8/45 (18%)
		Tudor_TDRD5	474..590	CDD:410490	19/127 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	694..728