Protein Alignment vret and TDRD7

DIOPT Version :10

• Sequence 1: NP_651092.1
• Gene: vret / 42695
• FlyBaseID: FBgn0263143
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_055105.2
• Gene: TDRD7 / 23424
• HGNCID: 30831
• Length: 1098
• Species: Homo sapiens
• Alignment Length: 761
• Identity: 147/761 - (19%)
• Similarity: 266/761 - (34%)
• Gaps: 215/761 - (28%)

  Fly    15 PMSREYYDQVGNRYTNESGQKLIMEAPLPPKDEKE--QRATRQAKYPYLVVPKSSPYVTEKMLIN 77
            |:.|.......||::.::..:..::..|.....||  ....:..:.|.:..|.|..|..:::
Human   176 PVQRHVTMSTNNRFSPKASLQPPLQMHLSRTSTKEMSDNLNQTVEKPNVKPPASYTYKMDEV--- 237

  Fly    78 FFGRALIKEMEFRRLSRVYF---------VYFENIASLETAQQRVQRYPNLI----KCITGR--- 126
               :..|||:..:..:.::.         :|.|::.  :...|:.:.:|::.    .|..|:
Human   238 ---QNRIKEILNKHNNGIWISKLPHFYKELYKEDLN--QGILQQFEHWPHICTVEKPCSGGQDLL 297

  Fly   127 --PQKERE-ITSDPVTSTEPM-PTPGPAISATERTPVNHNREVPISTGGQNHPEFFRPPLVTKDD 187
              |.|.:: :.|:..|...|: |.|||     ::||       |:.          ..|.|...|
Human   298 LYPAKRKQLLRSELDTEKVPLSPLPGP-----KQTP-------PLK----------GCPTVMAGD 340

  Fly   188 YKRGSLLATNDPIQRYLNVKYEFALER--HDIYKLKDETRIPQVVLHFRSGRTIPLSTVAVTEED 250
            :|.    ...|.:.:|.:..:..||.:  .::||:|                 .|        ||
Human   341 FKE----KVADLLVKYTSGLWASALPKAFEEMYKVK-----------------FP--------ED 376

  Fly   251 KTKSL--LEDGVSKCVVCQNWTDTFCKLCKMPFCNASCFADVAEQHK----QACGKGEILNLDEK 309
            ..|:|  |.|..|...:..| ........|:|........|..:.|.    :|..:.|.|.::|.
Human   377 ALKNLASLSDVCSIDYISGN-PQKAILYAKLPLPTDKIQKDAGQAHGDNDIKAMVEQEYLQVEES 440

  Fly   310 VGRK---------YPKPGLPPSGS-KVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVMMLGKDA 364
            :...         .|...:|...| .|.:.....||.|.:|                  .:|||.
Human   441 IAESANTFMEDITVPPLMIPTEASPSVLVVELSNTNEVVIR------------------YVGKDY 487

  Fly   365 SKLQS----------------TPV----CGQIVLYKF-EGHMSRAMVLNVDNIKEIYVVFIDFGS 408
            |..|.                |||    .||::.... |....||.|::.:..| |.|.::|:|.
Human   488 SAAQELMEDEMKEYYSKNPKITPVQAVNVGQLLAVNAEEDAWLRAQVISTEENK-IKVCYVDYGF 551

  Fly   409 VEVTQLERLYECSSYLAGLTCYPVAVKLRGVPRRFVGPNIREVMYELDQSLVFNIKYSSRE---- 469
            .|..:..:.|:.:.....|:......||.|:......|::.:|:..|....:|.::...:.
Human   552 SENVEKSKAYKLNPKFCSLSFQATKCKLAGLEVLSDDPDLVKVVESLTCGKIFAVEILDKADIPL 616

  Fly   470 ---YDTSKGMQVVVMTEIDINRSLNRLFKTILTPVEPSVSDLGYKEDCLPYIPLHCGKNINV-VV 530
               ||||        .|.|||                      ....||..|   |.|::.| :.
Human   617 VVLYDTS--------GEDDIN----------------------INATCLKAI---CDKSLEVHLQ 648

  Fly   531 MDNTFIQ------C--GFIYC-TSIDLAYEVTKMQRDIQEY---GEKIAKCATYAPPINELCIAK 583
            :|..:..      |  |.:|| .......:::.:.|.|::|   ....::|....|...::|:..
Human   649 VDAMYTNVKVTNICSDGTLYCQVPCKGLNKLSDLLRKIEDYFHCKHMTSECFVSLPFCGKICLFH 713

  Fly   584 YEGKWRRGLSVELVGDGYPSILFIDYGNIVPTHVTDIRPYPPQFI-----FPIMTTQLDLIGVPE 643
            .:|||.|.....:.......:.|:|.|.:....|:::|..||:|:     .|....:..|..:|:
Human   714 CKGKWLRVEITNVHSSRALDVQFLDSGTVTSVKVSELREIPPRFLQEMIAIPPQAIKCCLADLPQ 778

  Fly   644 KP---TDEQIKWLDKNYPIGSVITCSEITFDEETNSYSTRIEKLQE 686
            ..   |.:.:.||.     .||:.||:.         |.::.|:.|
Human   779 SIGMWTPDAVLWLR-----DSVLNCSDC---------SIKVTKVDE 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vret	NP_651092.1	TUDOR	322..438	CDD:425754	30/137 (22%)
		Tudor_vreteno-like_rpt1	371..424	CDD:410515	15/57 (26%)
		TUDOR	524..640	CDD:425754	27/133 (20%)
		Tudor_vreteno-like_rpt2	576..631	CDD:410516	13/59 (22%)
TDRD7	NP_055105.2	LOTUS_1_TDRD7	4..91	CDD:193600
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	129..156
		LOTUS_2_TDRD7	234..300	CDD:193587	9/73 (12%)
		LOTUS_3_TDRD7	338..404	CDD:193588	18/95 (19%)
		Tudor_TDRD7_rpt1	492..589	CDD:410498	20/97 (21%)
		Tudor_TDRD7_rpt2	653..792	CDD:410499	27/138 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	855..874
		Interaction with CDK17. /evidence=ECO:0000250	861..1098
		Interaction with CABLES1. /evidence=ECO:0000250	893..1098
		Tudor_TDRD7_rpt3	930..1020	CDD:410500