Protein Alignment vret and TDRD6

DIOPT Version :10

• Sequence 1: NP_651092.1
• Gene: vret / 42695
• FlyBaseID: FBgn0263143
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001010870.1
• Gene: TDRD6 / 221400
• HGNCID: 21339
• Length: 2096
• Species: Homo sapiens
• Alignment Length: 560
• Identity: 115/560 - (20%)
• Similarity: 212/560 - (37%)
• Gaps: 114/560 - (20%)

  Fly   212 LERHD---IYKLKDETRIPQVVLHFRSGRTIPLSTVAVTEEDKTK-SLLEDGVSKCVVCQNWTDT 272
            |::.|   :.::.||:|..:..:    .:.|..:..|..:|.:|| ::|.:..|...|..::|
Human   634 LDKQDHQYVIEILDESRTGEENI----SKVIAQAGYAKYQEFETKENILVNAHSPGHVSNHFT-- 692

  Fly   273 FCKLCKMPFCNASCFADVAEQHKQACGKGEILN-------------LDEKVGRK---YP------ 315
             .:..|:||.........|::..:.....:.|:             :.|||.|.   :|
Human   693 -TESNKIPFAKTGEGEQKAKRENKTTSVSKALSDTTVVTNGSTELVVQEKVKRASVYFPLMQNCL 756

  Fly   316 --KPGLPPSGS-------KVRITAFEQTNVVYVR-SADIQ------IDIAYYTVLTEVMMLGKDA 364
              |||....|.       :||::..|.....:.: :.:||      .||.||...|.       |
Human   757 EIKPGSSSKGELEVGSTVEVRVSYVENPGYFWCQLTRNIQGLKTLMSDIQYYCKNTA-------A 814

  Fly   365 SKLQSTPVCGQIVLYKFEGHMSRAMVLNVDNIKEIYVVFIDFGSVEVTQLERLYECSSYLAGLTC 429
            ...::|..|  :.........|||::..:.:::.:.|.|:|:|..|:..::.:|..|.....:..
Human   815 PHQRNTLAC--LAKRTVNRQWSRALISGIQSVEHVNVTFVDYGDREMVSVKNIYSISEEFLKVKA 877

  Fly   430 YPVAVKLRGVPRRFVGPNIREVMYELDQSLVFNIKYSSREYDTSKGMQVVVMTEIDINRSLNRLF 494
            ......|..:.:. ||.|  ..::::.....|| ::....:..:..::..:.....||..|..:.
Human   878 QAFRCSLYNLIQP-VGQN--PFVWDVKAIQAFN-EFIDNAWQKNLELKCTIFALASINEELFNIV 938

  Fly   495 KTILTPVEPSVSDLGYKEDCLP---YIPLHCGKNINVVVMDNTFIQCG---FIYCTSID------ 547
             .:|||.:.:...|..|....|   ..||.....::........::.|   .:|.|.||
Human   939 -DLLTPFQSACHFLVEKRLARPVKLQKPLESSVQLHSYFYSTHDMKIGSEELVYITHIDDPWTFY 1002

  Fly   548 --LAYEVTKMQR---DIQEYGEKIAKCATYAPPIN--ELCIAKY-EGKWRRGLSVELVGDGYPSI 604
              ||.....:::   .|.:..:.:....|  .|:|  .||:||| :|.|.||:.:|   .....:
Human  1003 CQLARNANILEQLSCSITQLSKVLLNLKT--SPLNPGTLCLAKYTDGNWYRGIVIE---KEPKKV 1062

  Fly   605 LFIDYGNIVPTHVTDIRPYPPQ----FIFPIMTTQLDLIGVPEKPTDEQIKW-----LDKNY--- 657
            .|:|:|||......|:.|.|..    .:.|:...:..|..:|:...:|.:.|     |||:.
Human  1063 FFVDFGNIYVVTSDDLLPIPSDAYDVLLLPMQAVRCSLSDIPDHIPEEVVVWFQETILDKSLKAL 1127

  Fly   658 -----PIGSVIT---CSEITFDEETN------SYSTRIEK 683
                 |.|::|.   ...|......|      ||..||.|
Human  1128 VVAKDPDGTLIIELYGDNIQISASINKKLGLLSYKDRIRK 1167

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vret	NP_651092.1	TUDOR	322..438	CDD:425754	25/129 (19%)
		Tudor_vreteno-like_rpt1	371..424	CDD:410515	11/52 (21%)
		TUDOR	524..640	CDD:425754	31/136 (23%)
		Tudor_vreteno-like_rpt2	576..631	CDD:410516	19/61 (31%)
TDRD6	NP_001010870.1	Tudor_TDRD6_rpt1	6..136	CDD:410491
		Tudor_TDRD6_rpt2	240..380	CDD:410492
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	287..316
		Tudor_TDRD6_rpt3	488..622	CDD:410493
		Tudor_TDRD6_rpt4	815..893	CDD:410494	14/80 (18%)
		Tudor_SF	975..1100	CDD:470623	30/129 (23%)
		Tudor_TDRD6_rpt6	1306..1420	CDD:410496
		Tudor_TDRD6_rpt7	1521..1663	CDD:410497