Protein Alignment vret and TDRD5

DIOPT Version :10

• Sequence 1: NP_651092.1
• Gene: vret / 42695
• FlyBaseID: FBgn0263143
• Length: 691
• Species: Drosophila melanogaster
• Sequence 2: NP_001186014.1
• Gene: TDRD5 / 163589
• HGNCID: 20614
• Length: 1035
• Species: Homo sapiens
• Alignment Length: 1005
• Identity: 186/1005 - (18%)
• Similarity: 308/1005 - (30%)
• Gaps: 385/1005 - (38%)

  Fly     5 SSQDDWSAFDPMSREYYDQVGN---------RYTNE--------------SGQKLIMEAPLPPKD 46
            |::|..|. ..:.:||...|||         |.|.|              :|..:|::| :|.:.
Human    21 STKDGLSP-QELEKEYLLMVGNHLPLRILGYRSTMELVLDMPDVVRVCPGAGGTVILKA-IPDES 83

  Fly    47 EK-------EQRAT---------------------RQAKYPYLVVP------KS--------SPY 69
            .|       :||::                     |:..|...|.|      ||        ||.
Human    84 TKGIASLVAKQRSSHKLRNSMHKGRPSIYSGPRSHRRVPYRGRVAPILPAVVKSELKDLLALSPV 148

  Fly    70 VT---EKMLINFFGRALIKEMEFRRLSRVYFVYFE--NIAS--LETAQQRVQRYPNLIKCIT--- 124
            :.   ||.....|||:      |:.:...:...||  |.||  :...|.|......|.|.:|
Human   149 LLSDFEKAFAKRFGRS------FQYMQYGFLSMFEVLNAASDVISVEQTRAGSLLMLKKSVTEEK 207

  Fly   125 --GRPQKE--------------------REITSDPVTSTEPMPTPGPAISATERTPVNHNREVPI 167
              |.|..:                    :...|.|.::.||   |...:|..:.:.:|     .:
Human   208 PRGCPAGKIFTQPFRMKQGSYSTGFPVAKPCFSQPTSNMEP---PKQIMSMEKTSKLN-----VV 264

  Fly   168 STGGQNHPEFFRPPLVTKDDYKRGSLLATNDP---IQRYLNVKYEFALERHD----IYKLKDETR 225
            .|...||.|....   .::.:|  |::|...|   |...|..|.:|.:.:..    |.||..|..
Human   265 ETSRLNHTEKLNQ---LENTFK--SVIAQIGPGGTISSELKHKIKFVVSKFPEGLFISKLLGEYE 324

  Fly   226 I-------PQV---------------VLH--FRSGR---------TIPLSTVAVTEEDKTKSLL- 256
            :       |:.               :||  ||.|.         ..||..|...::.:.|:.:
Human   325 VIFKEQLSPKKLGFLNVTELVGALSDILHVEFRKGHQDLLVFDADKKPLPPVQSDKKIEAKACVS 389

  Fly   257 ---EDGVSKCVVCQN-WTDTFC----------KLCKMPFCNASCFADVAEQHKQACGKGEILNL- 306
               .:.:|...|.:. |.   |          |:||.|...........|.:|..      |||
Human   390 SPPRNSLSTAAVKETVWN---CPSKKQKEPQQKICKKPNLVVKPLQLQVETNKSE------LNLA 445

  Fly   307 --------DEKVGRKYPKPGLPPSGSKVRITAFEQTNVVYVRSADIQIDIAYYTVLTEVMMLGKD 363
                    |....:|..:  |||..:...|..|    |.|:.|.. |..|..|:         :|
Human   446 MANHDIPPDAVPNKKLCR--LPPLDTSSLIGVF----VEYIISPS-QFYIRIYS---------RD 494

  Fly   364 ASKLQSTPV-----C--GQIVLYKF--------EGHMS-----------RAMVLNVDNIKEIYVV 402
            :|:|....:     |  .|:|..::        .||:.           |.::..|...:|:.|.
Human   495 SSELLEDMMIEMRRCYSNQLVSDRYVMPECFIQPGHLCCVRISEDKWWYRVIIHRVLEKQEVEVF 559

  Fly   403 FIDFGSVEVTQLERLYECSSYLAGLTCYPVAVKLRGVP---------------------RRFVG- 445
            :.|||::.:.|       .|.|..|.|....:..:.:|                     ::..|
Human   560 YPDFGNIGIVQ-------KSSLRFLKCCYTKLPAQAIPCSLAWVRPVEEHWTSKAILQFQKLCGL 617

  Fly   446 -PNIREVMYELDQSL-VFNIKYSSRE----------------------------------YDTSK 474
             |.:..|...:|..| :|....||.|                                  |.||.
Human   618 KPLVGVVDEYVDGILNIFLCDTSSNEDVYFHHVLRTEGHAIVCRENISSKGFSELNPLALYTTSS 682

  Fly   475 -GMQVVVMTEI----------------------------DIN--RSLNRLFKTILTPVEPS---- 504
             |.:.:|:||:                            |||  :||:.|......|::.|
Human   683 GGPEDIVLTELGYPSQQHYFNEDRKISPQSKESELRILQDINDEKSLSHLKSESKEPLKDSEFES 747

  Fly   505 --VSDLGYKEDCLPYIPLHCGKNINVVVMDN-TFIQCGFIYCTSIDLAYEV-----TKMQRDIQE 561
              ..:..::||     |.......|.:..:| ..|..|.....|:.:..::     ..:|..:.:
Human   748 LKTCNKSFEED-----PKWSNPEPNDLKEENEDEIPTGMPCLESVTIGDDIWDENWLPLQAKMGK 807

  Fly   562 YGEKIAKCAT--------YAP----PINELCIA----KYEGKWR-----RGLSVELVGDGYPSIL 605
            .|:..:...|        |:.    |..:.|.:    .::..|:     .|..||:   ..|.:|
Human   808 GGDAASHLFTASLGGKNQYSSCKEMPQKDWCFSTPKDTWDDSWQPSGLVNGTKVEV---HKPEVL 869

  Fly   606 FIDYGNIVPTHVT----DIR--------PYPPQFIFPIMTTQLDLIGVPEKPTDEQIKWLDKNYP 658
            .....| ..|:.|    ||.        |...:|...:..::....|...:|.:.|.:  .|...
Human   870 GAQEKN-TGTNRTQKQLDINGSSDSSTLPKLEEFCTSLTQSEQSADGSQSEPNNSQTQ--PKQIQ 931

  Fly   659 IGSVITCSEITFDEETNSYSTRIEKLQEFL 688
            :.:...||....|:.....|..:|...|.|
Human   932 LSTAAPCSTTAVDDSAEKPSGSVESSPEIL 961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vret	NP_651092.1	TUDOR	322..438	CDD:425754	28/141 (20%)
		Tudor_vreteno-like_rpt1	371..424	CDD:410515	14/78 (18%)
		TUDOR	524..640	CDD:425754	24/154 (16%)
		Tudor_vreteno-like_rpt2	576..631	CDD:410516	14/75 (19%)
TDRD5	NP_001186014.1	LOTUS_1_TDRD5	4..98	CDD:193599	18/78 (23%)
		LOTUS_2_TDRD5	132..201	CDD:193589	18/74 (24%)
		LOTUS_3_TDRD5	296..369	CDD:193590	13/72 (18%)
		Tudor_TDRD5	476..593	CDD:410490	28/137 (20%)