DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and RNT1

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_013966.1	Gene:	RNT1 / 855280	SGDID:	S000004852	Length:	471	Species:	Saccharomyces cerevisiae

Alignment Length:	537	Identity:	111/537 - (20%)
Similarity:	183/537 - (34%)	Gaps:	173/537 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1523 EKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLVPH 1587
            :|.|....:.....:.:|:...||.||.| |.|..:.|....|:.|.::.||   :||...::..
Yeast     9 KKTQNDNKLDNENGSQQRENINTKTLLKG-NLKISNYKYLEVIQLEHAVTKL---VESYNKIIEL 69

  Fly  1588 DQQLV-----LKRSDAAEAQV------------AKVSMME------LLKQLLPYVNEDVLAKKLG 1629
            ...||     :...|....|:            |::..:.      :|.::..|.||....:|..
Yeast    70 SPNLVAYNEAVNNQDRVPVQILPSLSRYQLKLAAELKTLHDLKKDAILTEITDYENEFDTEQKQP 134

  Fly  1630 DRRELLLSDLVEL-NADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERIEIEPPT 1693
            ..:|:..:|:.:| ..:.|.|.::|..:|          |.:.  ||:||:.:.:.|..:...||
Yeast   135 ILQEISKADMEKLEKLEQVKREKREKIDV----------NVYE--NLNEKEDEEEDEGEDSYDPT 187

  Fly  1694 STKAITSAI-----LPAGFSFDRQPDLVGHPGP-SPSIILQALTMSNANDGINLERLETIGDSFL 1752
            ....|..|.     ||.......:..:..|... ...:.|....|.||::    ||||.:|||.|
Yeast   188 KAGDIVKATKWPPKLPEIQDLAIRARVFIHKSTIKDKVYLSGSEMINAHN----ERLEFLGDSIL 248

  Fly  1753 KYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIATKFEPHDNWLPPCYYVP 1817
            ...:|..:|..:.:..||:||.||...|:|         :::.::.|...|
Yeast   249 NSVMTLIIYNKFPDYSEGQLSTLRMNLVSN---------EQIKQWSIMYNF-------------- 290

  Fly  1818 KELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQNGGAQNGQLDDSNDSCN 1882
                           |.||....|:|                    ::|...|||:|
Yeast   291 ---------------HEKLKTNFDLK--------------------DENSNFQNGKL-------- 312

  Fly  1883 DFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGAL-LFMAWLGVRVLPITRQLDGGNQ 1946
                              |..||..||.||. |:|..||..| ....||        |:|
Yeast   313 ------------------KLYADVFEAYIGG-LMEDDPRNNLPKIRKWL--------RKL----- 345

  Fly  1947 EQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQL-LSGFEEFEESLGYKFRDRSYL 2010
                   .||..|...         |:.:      |.|:.|:| ::...:....:||... |.:.
Yeast   346 -------AKPVIEEAT---------RNQV------ALEKTDKLDMNAKRQLYSLIGYASL-RLHY 387

  Fly  2011 LQAMTHASYTPNRLTDC 2027
            :......:..||.:.:|
Yeast   388 VTVKKPTAVDPNSIVEC 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333	46/206 (22%)
		RIBOc	2008..2172	CDD:238333	3/20 (15%)
		DSRM_DICER	2177..2240	CDD:380680
RNT1	NP_013966.1	RNase_3_N	44..147	CDD:408290	19/105 (18%)
RNT1	NP_013966.1	Rnc	183..440	CDD:223644	71/347 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810