DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Dcr-1 and DCL1

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_001184881.1 Gene:DCL1 / 839574 AraportID:AT1G01040 Length:1910 Species:Arabidopsis thaliana


Alignment Length:2410 Identity:468/2410 - (19%)
Similarity:759/2410 - (31%) Gaps:1032/2410 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARRHGR--VSVYLSCEVGTSTEPCS 80
            |.:|:::|..|..:|||..|...:.|..||:.|::.:.:......|  :||:|..:|....:...
plant   250 RRYQLDVLEQAKAKNTIAFLETGAGKTLIAILLIKSVHKDLMSQNRKMLSVFLVPKVPLVYQQAE 314

  Fly    81 IYTMLT-------------HLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEGFLYLLETRELLL 132
            :....|             ...|.|.||.:          :....|.::..:..|.:|....:.:
plant   315 VIRNQTCFQVGHYCGEMGQDFWDSRRWQRE----------FESKQVLVMTAQILLNILRHSIIRM 369

  Fly   133 SSVELIVLEDCHDSAVYQRIRPLFENHIMPAPPAD-RPRILGL-AGPLHSAGCELQQLSAM---- 191
            .:::|::|::|| .||.:....|..:......|.| ||.|.|: |.|::..|...|...|:    
plant   370 ETIDLLILDECH-HAVKKHPYSLVMSEFYHTTPKDKRPAIFGMTASPVNLKGVSSQVDCAIKIRN 433

  Fly   192 LATLEQSVLCQIETASDIVTVLRYCSRPHEYIVQ----CAPFEMDE-LSLVLADVLNTHKSFLLD 251
            |.|...|.:|.|:...::.   ::...|.|.:|:    ...:.:.| :..::|.|....::....
plant   434 LETKLDSTVCTIKDRKELE---KHVPMPSEIVVEYDKAATMWSLHETIKQMIAAVEEAAQASSRK 495

  Fly   252 HRYDPYEIYGTDQFM--------DELKDI--------PDPKVDPLNVINSLLVVLHEMGPWCTQR 300
            .::         |||        |||:.:        .|...:.::.:.::...|.|:|.||..:
plant   496 SKW---------QFMGARDAGAKDELRQVYGVSERTESDGAANLIHKLRAINYTLAELGQWCAYK 551

  Fly   301 AAHHF---YQCNEKL--KVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERY 360
            ....|   .|.:|::  :|....:..||...:   :|:|    ||               .:|..
plant   552 VGQSFLSALQSDERVNFQVDVKFQESYLSEVV---SLLQ----CE---------------LLEGA 594

  Fly   361 SSPKVRRLLQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRA 425
            ::.||     .....|||                     |..:|         |:|::.......
plant   595 AAEKV-----AAEVGKPE---------------------NGNAH---------DEMEEGELPDDP 624

  Fly   426 LVATLEQILHTTEDRQTNRSAA--RVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHND 488
            :|:..|.:     |.....:.|  :||         ||..|        ..:.:...:|..|.. 
plant   625 VVSGGEHV-----DEVIGAAVADGKVT---------PKVQS--------LIKLLLKYQHTADFR- 666

  Fly   489 GSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEE 553
                  |:::..:...|.||.::.||:    |.|.|:||       |.........|::..:.::
plant   667 ------AIVFVERVVAALVLPKVFAEL----PSLSFIRC-------ASMIGHNNSQEMKSSQMQD 714

  Fly   554 VLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSY 618
            .:.:||.....:|:.|||.|||:|:.:||:|:|:|...|..:|:|.:||||              
plant   715 TISKFRDGHVTLLVATSVAEEGLDIRQCNVVMRFDLAKTVLAYIQSRGRAR-------------- 765

  Fly   619 KSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVKILNPEVFSKQ 683
                                                  ..||| |.....||.|.          
plant   766 --------------------------------------KPGSD-YILMVERGNVS---------- 781

  Fly   684 PPTACDIKLQEIQDELPAAAQLDTSNSSDEAVSMSNTSPSESSTEQKSRRFQCELSSLTEPEDTS 748
                             .||.|..:.:|:|.:                |:...|.:.|:..:|||
plant   782 -----------------HAAFLRNARNSEETL----------------RKEAIERTDLSHLKDTS 813

  Fly   749 DTTAEIDTAHSLASTTKDLVHQMAQYREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPH 813
                                           .|:|  .:..|....:.||               
plant   814 -------------------------------RLIS--IDAVPGTVYKVEA--------------- 830

  Fly   814 LLTGASVDLGSAIALVNKYCARLPSDTFTKLTALWRCTRNER-AGVTLFQYTLRLPINSPLKHDI 877
              |||.|.|.||:.||:.||::||.|.:..|...:...::|: .|.|.:...|:||.|:|.  :|
plant   831 --TGAMVSLNSAVGLVHFYCSQLPGDRYAILRPEFSMEKHEKPGGHTEYSCRLQLPCNAPF--EI 891

  Fly   878 VGLPM-PTQTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQLS 941
            :..|: .:..||::...|.||.:||.:|...|.|.|....|..|.:.|        :|::     
plant   892 LEGPVCSSMRLAQQAVCLAACKKLHEMGAFTDMLLPDKGSGQDAEKAD--------QDDE----- 943

  Fly   942 DEPRPGTTKRRQYYYKRIA-----------SEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRG 995
            .||.|||.:.|::|.:.:|           .|.|:...:  ...|:|.::..             
plant   944 GEPVPGTARHREFYPEGVADVLKGEWVSSGKEVCESSKL--FHLYMYNVRCV------------- 993

  Fly   996 RKIYPPEDAQQGFGILTTKRIPKLSAFSIF---TRSGEV--KVSLELAKERVILTSEQIVCINGF 1055
                       .||......:.::|.|:|.   ....||  .:|::|...|.::|...: ...|.
plant   994 -----------DFGSSKDPFLSEVSEFAILFGNELDAEVVLSMSMDLYVARAMITKASL-AFKGS 1046

  Fly  1056 LNYTFTNVLRLQKF---LMLF------DPDST----ENCVFIVP----TVKAPAGGKHIDWQFLE 1103
            |:.|...:..|:||   ||..      :|.:|    ......||    |...|..|  |:|:.:|
plant  1047 LDITENQLSSLKKFHVRLMSIVLDVDVEPSTTPWDPAKAYLFVPVTDNTSMEPIKG--INWELVE 1109

  Fly  1104 LI---QANGNTMPRAVPD-----------EERQAQPFDPQRFQDAVVMPWYRNQDQPQY------ 1148
            .|   .|..|.:.||.||           .:|:...|...|..  :|   :..:..|.|      
plant  1110 KITKTTAWDNPLQRARPDVYLGTNERTLGGDRREYGFGKLRHN--IV---FGQKSHPTYGIRGAV 1169

  Fly  1149 --------------------------------------------------------FYVAEICPH 1157
                                                                    |||..||..
plant  1170 ASFDVVRASGLLPVRDAFEKEVEEDLSKGKLMMADGCMVAEDLIGKIVTAAHSGKRFYVDSICYD 1234

  Fly  1158 LSPLSCFPGD-------NYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNFLTPRYVNRKGVA 1215
            :|..:.||..       .|.|:..||..|||:.:....|||:.....|...|.|:||:..     
plant  1235 MSAETSFPRKEGYLGPLEYNTYADYYKQKYGVDLNCKQQPLIKGRGVSYCKNLLSPRFEQ----- 1294

  Fly  1216 LPTSSEETKRAKRENLEQKQILVPELCTVHPFPASLWRTAVCLPCILYRINGLLLADDIRKQVSA 1280
              :...||...|...:    .|.||||.|||...||.|.|..||.|:.|:..:|||         
plant  1295 --SGESETVLDKTYYV----FLPPELCVVHPLSGSLIRGAQRLPSIMRRVESMLLA--------- 1344

  Fly  1281 DLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDTINGKDLADVEKKPTSEETQL 1345
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1346 DKDSKDDKVEKSAIELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPA 1410
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1411 NVKFCDQQTRYGSPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDD 1475
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1476 DDNAGPLNYMHHNYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANER 1540
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1541 QYQQTKNLLIGFNFKHEDQKEPATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRSDAAEAQVAK 1605
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1606 VSMMELLKQLLPYVNEDVLAKKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDH 1670
                                                                             
plant  1345 ----------------------------------------------------------------- 1344

  Fly  1671 HRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNA 1735
                   .|||                                :|:.:|.|: |.||:|||.::.
plant  1345 -------VQLK--------------------------------NLISYPIPT-SKILEALTAASC 1369

  Fly  1736 NDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEYMIA 1800
            .:....||.|.:||::||:.::.:|::.|...|||:|:.:|.:.|:|:.||:....|.|..|:.|
plant  1370 QETFCYERAELLGDAYLKWVVSRFLFLKYPQKHEGQLTRMRQQMVSNMVLYQFALVKGLQSYIQA 1434

  Fly  1801 TKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALGLEQ 1865
            .:|.| ..|..|  .||...::                  |.|:..|    ....|:...:..|.
plant  1435 DRFAP-SRWSAP--GVPPVFDE------------------DTKDGGS----SFFDEEQKPVSEEN 1474

  Fly  1866 NGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPRGALLFMAWL 1930
            :...::|:::|..         :..:|.|...:..|::||.||||||.|.:|.|...|...|.|:
plant  1475 SDVFEDGEMEDGE---------LEGDLSSYRVLSSKTLADVVEALIGVYYVEGGKIAANHLMKWI 1530

  Fly  1931 GVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEELDQLLSGFEE 1995
            |:.|.....::||..:...:|       |:|:                     :.:|     |..
plant  1531 GIHVEDDPDEVDGTLKNVNVP-------ESVL---------------------KSID-----FVG 1562

  Fly  1996 FEESLGYKFRDRSYLLQAMTHASYTPNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALT 2060
            .|.:|.|:|:::..|::|:|||| .|:....|||||||:||||||:||||||:.......||.||
plant  1563 LERALKYEFKEKGLLVEAITHAS-RPSSGVSCYQRLEFVGDAVLDHLITRHLFFTYTSLPPGRLT 1626

  Fly  2061 DLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVR-IQQENGHCISEEYYLLSEEECDD 2124
            |||:|.|||..||.:||:|..|.:.||.|..|...|..||: :|.|:.......:.|        
plant  1627 DLRAAAVNNENFARVAVKHKLHLYLRHGSSALEKQIREFVKEVQTESSKPGFNSFGL-------- 1683

  Fly  2125 AEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLE---- 2185
             .|.:.||.|||:.|||||||||||.......|.|:..::.|.:.  ..::|..|:|||.|    
plant  1684 -GDCKAPKVLGDIVESIAGAIFLDSGKDTTAAWKVFQPLLQPMVT--PETLPMHPVRELQERCQQ 1745

  Fly  2186 ----LEPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRN--YRIAKCTAAKCALRQLKKQGL 2244
                ||.:.::.|.          ..||:||..|...|:.:|  .::|:..||:.||..||::.:
plant  1746 QAEGLEYKASRSGN----------TATVEVFIDGVQVGVAQNPQKKMAQKLAARNALAALKEKEI 1800

  Fly  2245 IAKKD 2249
            ...|:
plant  1801 AESKE 1805

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 48/210 (23%)
Dicer_PBD 240..344 CDD:277191 23/124 (19%)
DEAD-like_helicase_C 490..614 CDD:365791 35/123 (28%)
Dicer_dimer 825..916 CDD:397444 30/92 (33%)
PAZ_dicer_like 1091..1212 CDD:239209 41/203 (20%)
RIBOc 1724..1930 CDD:238333 57/205 (28%)
RIBOc 2008..2172 CDD:238333 73/164 (45%)
DSRM_DICER 2177..2240 CDD:380680 20/72 (28%)
DCL1NP_001184881.1 DEXDc 250..456 CDD:214692 48/219 (22%)
DEXDc 263..415 CDD:238005 35/162 (22%)
Helicase_C 648..764 CDD:278689 36/141 (26%)
Dicer_dimer 841..927 CDD:281376 28/87 (32%)
PAZ_CAF_like 1177..1321 CDD:239210 34/154 (22%)
RIBOc 1358..1537 CDD:238333 60/212 (28%)
Rnc 1558..1785 CDD:223644 96/253 (38%)
RIBOc 1576..1731 CDD:238333 73/166 (44%)
DSRM 1735..1785 CDD:214634 16/59 (27%)
DSRM 1832..1905 CDD:294045
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 102 1.000 Domainoid score I2292
eggNOG 1 0.900 - - E1_COG0571
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 473 1.000 Inparanoid score I346
OMA 1 1.010 - - QHG57860
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 1 1.000 - - FOG0002051
OrthoInspector 1 1.000 - - mtm1149
orthoMCL 1 0.900 - - OOG6_101152
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1728
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1211.740

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