DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and RTL3

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_199328.1	Gene:	RTL3 / 834551	AraportID:	AT5G45150	Length:	957	Species:	Arabidopsis thaliana

Alignment Length:	679	Identity:	141/679 - (20%)
Similarity:	242/679 - (35%)	Gaps:	213/679 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1724 SIILQALTMSNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRL 1788
            :::.:|:|..:.    ..:|||..|||.|:.|.|.|:..||.|:...:|..||:..|:|....|:
plant    19 TLLKEAITQKSP----LFDRLEFFGDSILEVAFTNYICHTYPNLKVKELRDLRTANVSNEKFARI 79

  Fly  1789 GRRKRLGEYMI--------------------------------------------ATKF------ 1803
            .....|..:::                                            ||.|
plant    80 AVNHNLHHFLLLQNPSLFKKVKNFAEAVRKEDDPVPYGGLVKAPKILADTLESIAATVFIDVNYD 144

  Fly  1804 -----EPHDNWLPPCYYVPKELEKALIEAKIP----------------------THHWKL----- 1836
                 |...:.|.| .|.|.:|   |::.|:|                      |...|:
plant   145 VKRLWEIFRSLLEP-IYTPDDL---LLQPKLPFLTLFRLADKHGSESTSGIRKMTTSTKILLRNK 205

  Fly  1837 ----ADLLDIKNLSSVQIC-------EMVREKA--DALGLEQ---NGGAQNGQLDDSNDSCNDFS 1885
                .||.|:|. .|.:||       ..|.|.:  |.:..|:   :..:.|.:.:|......:.
plant   206 DCLDVDLEDVKG-KSFEICSTELFSLSTVSENSLTDEMSQEEVVIDEDSPNVEPEDVKGKLFEI- 268

  Fly  1886 CF--------------IPYNLVSQHSIPDKSIADCVEALIG-AYLIE-C---------------- 1918
            |:              :.|.:.::..:.||.... ||.:.| ..||| |
plant   269 CYTRKLQIQTGSSGNPLTYEMTTKQMVVDKDSLH-VEPVNGRGELIEICTKNKWPRPIFSVQEEK 332

  Fly  1919 GPRGALLFMAWLGVRVLPI--TRQLDGGNQEQRIPGSTKPNAEN--------------VVTVYGA 1967
            ||:....|:..:.:.:..|  |..:.|..:      |.|..|||              |..|...
plant   333 GPKNEPKFVCSVKIEIPNIEGTFHMKGDIK------SKKKQAENSLAYHMIRALESSLVSLVISN 391

  Fly  1968 WPTPRS------PLLHFAPNATEELDQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTD 2026
            ...|:|      |||.     :.|:|   |..|..|:.|.|.|.:::.|.:.:||.:      :.
plant   392 LQKPKSLDEKNNPLLF-----SSEMD---SSVEAVEKILNYSFVNKTLLKELLTHNN------SP 442

  Fly  2027 CYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPG 2091
            .:|.|.|:|::.|....|:|||.......|..|:.||.|...:..:|.:||:.|.::.|....|.
plant   443 LFQGLMFVGESALSLAFTKHLYLTYPMLEPKDLSVLRDANTCHDKYACVAVKKGIYQSFIGSVPK 507

  Fly  2092 LNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVV 2156
            ...:...|:.              |:.:|: |....|:.||.|.::...:|||:::|...::..:
plant   508 PEKMTTDFIE--------------LMGKED-DPYRVVKAPKILVNLLAGVAGAVYIDVKYNVQRL 557

  Fly  2157 WHVYSNMMSP--EIEQFSNSVPKSPIRELLELEPETAK-----FGKPEKLADGRRVRVTVDVFCK 2214
            ..::..::.|  .::.....: |.|...|..|..:..|     :.|     ||...:....|:..
plant   558 LEIFRVLLEPIYTLDDLRMQL-KQPFLMLFRLADKHGKQIDFRYSK-----DGGSRKNIAQVYMD 616

  Fly  2215 GTFRGIGRNYRI--AKCTAAKCALRQLKK 2241
            ..|...|...||  ||..||:.|:::|.:
plant   617 DMFIASGCAKRIDTAKLLAAEEAIQKLSE 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333	63/335 (19%)
		RIBOc	2008..2172	CDD:238333	36/165 (22%)
		DSRM_DICER	2177..2240	CDD:380680	18/69 (26%)
RTL3	NP_199328.1	Rnc	1..>170	CDD:223644	32/158 (20%)
		RIBOc	19..165	CDD:238333	30/150 (20%)
		DSRM	307..381	CDD:294045	16/79 (20%)
		RNaseIII	419..643	CDD:274024	58/250 (23%)
		RIBOc	430..574	CDD:238333	36/164 (22%)
		dsrm	584..643	CDD:278464	16/63 (25%)
		DSRM	839..911	CDD:294045
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810