DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcr-1 and RTL2

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_566661.1	Gene:	RTL2 / 821587	AraportID:	AT3G20420	Length:	391	Species:	Arabidopsis thaliana

Alignment Length:	314	Identity:	88/314 - (28%)
Similarity:	145/314 - (46%)	Gaps:	46/314 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1947 EQRIPGSTKPNAENVVTVYGAWPTPRSPLLH-----FAPNA-----TEELDQLLSGFEEFEESLG 2001
            |...|..|:.:..|.:......|.|.|..:|     .:|:|     :.|::.:    |..|:.|.
plant     8 EYNFPAITRCSLSNSLPHRPPSPLPSSADIHRFYNSLSPSAPSVPVSSEMESM----EAVEKILN 68

  Fly  2002 YKFRDRSYLLQAMTHASYT--PNRLTDCYQRLEFLGDAVLDYLITRHLYEDPRQHSPGALTDLRS 2064
            |||.::|.|.:|:||.|.|  |:     |:||||:||:.:...|:.:||.......|..|:.||:
plant    69 YKFSNKSLLKEAITHTSCTDFPS-----YERLEFIGDSAIGLAISNYLYLTYPSLEPHDLSLLRA 128

  Fly  2065 ALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSEEECDDAED-- 2127
            |.|:....|.:::.||.:.|.|..:|.|::.:..|       ...:.:|         ||...
plant   129 ANVSTEKLARVSLNHGLYSFLRRNAPSLDEKVKEF-------SEAVGKE---------DDLSVSY 177

  Fly  2128 ---VEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNMMSPEIEQFSNSVPKSPIRELLELEPE 2189
               |:.||.|.|:|||:|||:::|.|..|..:|.::..::.|.:..........|:..|.:|..:
plant   178 GGLVKAPKVLADLFESLAGAVYVDVNFDLQRLWVIFRGLLEPIVTLDDLQKQPQPVSMLFKLCHK 242

  Fly  2190 TAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGR--NYRIAKCTAAKCALRQLKK 2241
            ..|....:...|| .|.:.| ::........||  |..||:..|||.|||:|.:
plant   243 HKKRIDIKNWKDG-NVSIAV-IYLDDELLASGRAENKDIARLIAAKEALRKLSE 294

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333
		RIBOc	2008..2172	CDD:238333	51/170 (30%)
		DSRM_DICER	2177..2240	CDD:380680	19/64 (30%)
RTL2	NP_566661.1	Rnc	54..294	CDD:223644	78/266 (29%)
		RIBOc	75..226	CDD:238333	51/171 (30%)
		dsrm	232..292	CDD:278464	19/61 (31%)
		DSRM	313..385	CDD:238007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002051
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810