DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-1 and DHX58

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:NP_077024.2 Gene:DHX58 / 79132 HGNCID:29517 Length:678 Species:Homo sapiens


Alignment Length:660 Identity:142/660 - (21%)
Similarity:232/660 - (35%) Gaps:222/660 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RDFQVELLATAYE-RNTIICL----GHRSSKEFIALKLLQELSRRARRHGRVSVYLSCEVGTSTE 77
            |.:|.|::..|.| :|.||.|    |...:..::|.:.|:.:.      |...|.|...|     
Human     4 RSYQWEVIMPALEGKNIIIWLPTGAGKTRAAAYVAKRHLETVD------GAKVVVLVNRV----- 57

  Fly    78 PCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPE-----GFLYLLETRELLLSSVE- 136
                     ||    |.|...:.:...|..||   |:.|..:     ||.:|....:||:.:.| 
Human    58 ---------HL----VTQHGEEFRRMLDGRWT---VTTLSGDMGPRAGFGHLARCHDLLICTAEL 106

  Fly   137 --------------------LIVLEDCHDS---AVYQRIRPLF-ENHIMPAPPADRPRILGLAGP 177
                                |||:::||.:   .||..|...: |..:..|.|.  |::|||...
Human   107 LQMALTSPEEEEHVELTVFSLIVVDECHHTHKDTVYNVIMSQYLELKLQRAQPL--PQVLGLTAS 169

  Fly   178 LHSAGCELQQLSAMLATLEQSVLCQIETASDIVTVLRYCSRPHEYIV----QCAPFEMDELSLVL 238
            ..:.|..                 :::.|  |..||:.|:....:.:    .|.| ::.|.|   
Human   170 PGTGGAS-----------------KLDGA--INHVLQLCANLDTWCIMSPQNCCP-QLQEHS--- 211

  Fly   239 ADVLNTHKSFLLDHRYDPYEIYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAH 303
               ....|.:.|.||      ...|.|.|.||.:.|...|.|.:            |..:::...
Human   212 ---QQPCKQYNLCHR------RSQDPFGDLLKKLMDQIHDHLEM------------PELSRKFGT 255

  Fly   304 HFYQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRL 368
            ..|   |:..||...          :.||..|.....:|.|            :.||:...:  :
Human   256 QMY---EQQVVKLSE----------AAALAGLQEQRVYALH------------LRRYNDALL--I 293

  Fly   369 LQTLRCFKPEEVHTQADGLRRMRHQVDQADFNRLSHTLESKCRMVDQMDQPPTETRALVATLEQI 433
            ..|:|.         .|.|..::      ||....|.               |:|:.|.|. .::
Human   294 HDTVRA---------VDALAALQ------DFYHREHV---------------TKTQILCAE-RRL 327

  Fly   434 LHTTEDRQTNRSAARVTPTPTPAHAKPK----------PSSGANTAQPRTRRRVYTRRHHRDHND 488
            |...:||: |..|...|..|    ..||          ..|.:|:    .|..::||.....|: 
Human   328 LALFDDRK-NELAHLATHGP----ENPKLEMLEKILQRQFSSSNS----PRGIIFTRTRQSAHS- 382

  Fly   489 GSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEE 553
                  .|::..|....:.: ::.|::                  :.......:...:..|.|:|
Human   383 ------LLLWLQQQQGLQTV-DIRAQL------------------LIGAGNSSQSTHMTQRDQQE 422

  Fly   554 VLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPSY 618
            |:::|:....|:|:.|||.|||:|:|.||:|||:...|...|.||.:|||||..:.:..:.    
Human   423 VIQKFQDGTLNLLVATSVAEEGLDIPHCNVVVRYGLLTNEISMVQARGRARADQSVYAFVA---- 483

  Fly   619 KSPTVGSVQL 628
               |.||.:|
Human   484 ---TEGSREL 490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 48/224 (21%)
Dicer_PBD 240..344 CDD:277191 21/103 (20%)
DEAD-like_helicase_C 490..614 CDD:365791 32/123 (26%)
Dicer_dimer 825..916 CDD:397444
PAZ_dicer_like 1091..1212 CDD:239209
RIBOc 1724..1930 CDD:238333
RIBOc 2008..2172 CDD:238333
DSRM_DICER 2177..2240 CDD:380680
DHX58NP_077024.2 MPH1 2..542 CDD:224036 142/660 (22%)
DEXDc 18..170 CDD:238005 41/180 (23%)
DECH box 131..134 0/2 (0%)
MDA5_ID 227..345 CDD:277189 37/188 (20%)
Helicase_C 350..472 CDD:278689 35/151 (23%)
LGP2_C 552..664 CDD:276944
RNA-binding 572..655
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1337630at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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