DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dcr-1 and Mrpl44

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_001074679.1	Gene:	Mrpl44 / 69163	MGIID:	1916413	Length:	333	Species:	Mus musculus

Alignment Length:	327	Identity:	71/327 - (21%)
Similarity:	117/327 - (35%)	Gaps:	93/327 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1971 PRSPLLHFAPNATEELDQLLSGFE---EFEESLGYKFRDRSYLLQA---MTHASYTPNRLTDCYQ 2029
            ||..|....|.....:..:..||.   .|::.|     :|..||:.   ....|..||  .|.:.
Mouse    13 PRRLLAPAVPTLAPPVRGVKKGFRAAFRFQKEL-----ERWRLLRCPPPPVRRSEKPN--WDYHA 70

  Fly  2030 RLEFLGDAV-----LDYLITRHL------YEDPRQHSPG-----ALTDLRSALVNNTIF-ASLAV 2077
            .::..|..:     ||.|.|..:      .|:.::.|.|     ||.:|:.   |..:| ..|:.
Mouse    71 EVQAFGSRLQETFSLDLLKTAFINSCYIKSEEAKRQSLGIEKEAALLNLKD---NQELFEQGLSF 132

  Fly  2078 RHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISEEYYLLSE------------EECDDAEDVEV 2130
            .|      |.|:..|.   |.|..:..|....:..  :|..|            |:...:.:..|
Mouse   133 SH------RCLTQFLE---DEFPDLPAEGTESLVS--FLTGEAVVCHVARNLAVEQLTLSAEFPV 186

  Fly  2131 P-KALGDVFESIAGAI---------------FLDSNMS---LDVVWHVYSNM--MSPEIEQFSNS 2174
            | ..|...|.::.||:               ||.:.|:   |..:|.|.:.|  :..|:::.:.|
Mouse   187 PLPVLRQTFFAVIGALLQSSGPERAALFIRDFLITQMTGKELFEMWTVVNPMGLLVEELKKRNIS 251

  Fly  2175 VPKSPIRELLELEPETAKFGKPEKLADGRRVRVTVDVFC--KGTFRGIGRNYRIAKCTAAKCALR 2237
            .|:|.:         |.:.|....|.     ...|.::|  |....|.|....:|:..||:.|||
Mouse   252 APESRL---------TRQSGSTTALP-----LYFVGLYCDRKLIAEGPGETVLVAEEEAARVALR 302

  Fly  2238 QL 2239
            :|
Mouse   303 KL 304

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333
		RIBOc	2008..2172	CDD:238333	44/216 (20%)
		DSRM_DICER	2177..2240	CDD:380680	16/65 (25%)
Mrpl44	NP_001074679.1	Rnc	77..305	CDD:223644	55/256 (21%)
		DSRM	236..304	CDD:294045	19/81 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	311..333
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900