DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dcr-1 and FANCM

DIOPT Version :9

Sequence 1:NP_524453.1 Gene:Dcr-1 / 42693 FlyBaseID:FBgn0039016 Length:2249 Species:Drosophila melanogaster
Sequence 2:XP_011535336.1 Gene:FANCM / 57697 HGNCID:23168 Length:2053 Species:Homo sapiens


Alignment Length:2009 Identity:369/2009 - (18%)
Similarity:656/2009 - (32%) Gaps:638/2009 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 RDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARRHGRVSVYLSCEVGTSTEPCSIY 82
            ||:|:.:...|...||::||.....|.|||..::....|.. ..|:| |:::     .|:|    
Human    92 RDYQLHISRAALFCNTLVCLPTGLGKTFIAAVVMYNFYRWF-PSGKV-VFMA-----PTKP---- 145

  Fly    83 TMLTHLTDLRVWQEQPDMQIPFDH---------------CWTDYHVSILRPEGFLYLLETRELLL 132
                 |...::......|.||..|               .|....|..|.|:..:..|.......
Human   146 -----LVTQQIEACYQVMGIPQSHMAEMTGSTQASTRKEIWCSKRVLFLTPQVMVNDLSRGACPA 205

  Fly   133 SSVELIVLEDCHDS----AVYQRIRPL--FENHIMPAPPADRPRILGLAGPLHSAGCELQQLSAM 191
            :.::.:|:::.|.:    |..|.:|.|  :.||.         |||.|:.   :.|.:::.:..:
Human   206 AEIKCLVIDEAHKALGNYAYCQVVRELVKYTNHF---------RILALSA---TPGSDIKAVQQV 258

  Fly   192 LATLEQSVLCQIETAS-DIVTVLRYCSRPHEYIVQ--CAPFEMDELSLVLADVLNTHKSF----- 248
            :..|   ::.|||..| |...:|.|   .||..|:  ..|.. :||:.:....:...:||     
Human   259 ITNL---LIGQIELRSEDSPDILTY---SHERKVEKLIVPLG-EELAAIQKTYIQILESFARSLI 316

  Fly   249 ---LLDHRYDP----YE-IYGTDQFMDELKDIPDPKVDPLNVINSLLVVLHEMGPWCTQRAAHHF 305
               :|..|..|    |: |...|||    :..|.|     |::.....::.  |.:....:.:|.
Human   317 QRNVLMRRDIPNLTKYQIILARDQF----RKNPSP-----NIVGIQQGIIE--GEFAICISLYHG 370

  Fly   306 YQCNEKLKVKTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQ 370
            |:..:::.:::    .|...|.:..                 |:...:|...|...:....:|..
Human   371 YELLQQMGMRS----LYFFLCGIMD-----------------GTKGMTRSKNELGRNEDFMKLYN 414

  Fly   371 TLRCFKPEEVHTQADGLRRMRHQVDQADFNR---LSHTLESKCRMVDQMDQPPTETRALVATLEQ 432
            .|.|.......|.|:|:    ..:.|.|.|:   .||....|                    ||:
Human   415 HLECMFARTRSTSANGI----SAIQQGDKNKKFVYSHPKLKK--------------------LEE 455

  Fly   433 IL--HTTEDRQTNRSAARVTPTPTPAHAKPKPSSGANTAQPRTRRRVYTRRHHRDHNDGSDTLCA 495
            ::  |.                        |..:..||.:   ::|..||              .
Human   456 VVIEHF------------------------KSWNAENTTE---KKRDETR--------------V 479

  Fly   496 LIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELEHRRQEEVLKRFRM 560
            :|:.:...:.:.:.|:|   |:..|   .:|........:..:|:    ....:.|.||:|:||.
Human   480 MIFSSFRDSVQEIAEML---SQHQP---IIRVMTFVGHASGKSTK----GFTQKEQLEVVKQFRD 534

  Fly   561 HDCNVLIGTSVLEEGIDVPKCNLVVRWDPPTTYRSYVQCKGRARAAPAYHVILVAPS-------- 617
            ...|.|:.|.|.|||:|:.:.:|::.:|...:....||..||........::::...        
Human   535 GGYNTLVSTCVGEEGLDIGEVDLIICFDSQKSPIRLVQRMGRTGRKRQGRIVIILSEGREERIYN 599

  Fly   618 ---------YK--------------SPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSG 659
                     ||              ||.:....:..:.|:.....| ..|.:..|.:  :...|.
Human   600 QSQSNKRSIYKAISSNRQVLHFYQRSPRMVPDGINPKLHKMFITHG-VYEPEKPSRN--LQRKSS 661

  Fly   660 SDPYTFGTARGTVK---ILNPEVFSK-------------QPPTACDIKLQEIQDELPAAAQLDTS 708
            ...|..|..:.::|   .|:.|.|..             :..|...::...:|:|....||..|:
Human   662 IFSYRDGMRQSSLKKDWFLSEEEFKLWNRLYRLRDSDEIKEITLPQVQFSSLQNEENKPAQESTT 726

  Fly   709 NSSDEAVS-----MSNTSPSES--------------------STEQKSRRFQCELSSLTEPED-T 747
            .....::|     ..:..|:..                    ..|:....::.|:.|..:.|| |
Human   727 GIHQLSLSEWRLWQDHPLPTHQVDHSDRCRHFIGLMQMIEGMRHEEGECSYELEVESYLQMEDVT 791

  Fly   748 SDTTAEIDTAHSLASTTKDLVHQMAQY-REIEQMLLS-------KCANTE-----PPEQEQSEAE 799
            |...|..:.:::|||.| .:.|:.:.: :.|.|...|       :||...     .|.:..|..:
Human   792 STFIAPRNESNNLASDT-FITHKKSSFIKNINQGSSSSVIESDEECAEIVKQTHIKPTKIVSLKK 855

  Fly   800 RFSACLAAYRPKPHLLTGA--SVDLGSAIALVNKYCARLPSDTFTKLT--ALWRCTRNER----- 855
            :.|..:...:.|.....|.  |||......:.|.:...||:|..|..|  ....||.||.     
Human   856 KVSKEIKKDQLKKENNHGIIDSVDNDRNSTVENIFQEDLPNDKRTSDTDEIAATCTINENVIKEP 920

  Fly   856 -AGVTLFQYTLRLPINSPLKHDIV---------------GLPMPTQTLARRLAALQACVELHRIG 904
             ..:|..|:|.:  ..|.|..:::               .|.:|.:.            ||: |.
Human   921 CVLLTECQFTNK--STSSLAGNVLDSGYNSFNDEKSVSSNLFLPFEE------------ELY-IV 970

  Fly   905 ELDDQLQPIGKEGFRALEPDWECFELEPEDEQIVQ--LSDEPRP-------------GTTKRRQY 954
            ..|||.              :.|..|..|....|:  ||..|.|             ||......
Human   971 RTDDQF--------------YNCHSLTKEVLANVERFLSYSPPPLSGLSDLEYEIAKGTALENLL 1021

  Fly   955 YY---KRIASEFCDCRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKI----YP---------PED 1003
            :.   :.:.|:.|.|              |.....:..:||.....:    ||         |.|
Human  1022 FLPCAEHLRSDKCTC--------------LLSHSAVNSQQNLELNSLKCINYPSEKSCLYDIPND 1072

  Fly  1004 AQQGFGILTTKRIPKLSAFSIFTRSGEVKVSLELAKERV-------------ILTSEQIVCINGF 1055
            .......|....:.|.:.......:..|::....|:..|             :|:::|       
Human  1073 NISDEPSLCDCDVHKHNQNENLVPNNRVQIHRSPAQNLVGENNHDVDNSDLPVLSTDQ------- 1130

  Fly  1056 LNYTFTNVLRLQKFLMLFDPDSTE-NCVFIVP----TVKAPAGGK------HIDWQFL---ELIQ 1106
                       .:.|:||:..:|| :.|.:.|    :...|...|      .:..|||   ||:.
Human  1131 -----------DESLLLFEDVNTEFDDVSLSPLNSKSESLPVSDKTAISETPLVSQFLISDELLL 1184

  Fly  1107 ANGNTMPRAVPDEERQAQPFDPQRFQDAVVMPWYRNQD-----QPQYFYVA------------EI 1154
            .|.:.:...:..:....:..|.:..|:..|    :|.:     ....|.|.            ||
Human  1185 DNNSELQDQITRDANSFKSRDQRGVQEEKV----KNHEDIFDCSRDLFSVTFDLGFCSPDSDDEI 1245

  Fly  1155 CPHLS----PLSCFPGDNYRTFKHYYLVKYGLTIQNTSQPLLDVDHTSARLNFLT---------- 1205
            ..|.|    ||....| .|...|......|   :.|  |.|:..||:.   ||.:          
Human  1246 LEHTSDSNRPLDDLYG-RYLEIKEISDANY---VSN--QALIPRDHSK---NFTSGTVIIPSNED 1301

  Fly  1206 ---PRYVNRKGVALPTSSEETKRAKRENL---EQKQILVPELCTVHPFPASLWRTAVCLPCILYR 1264
               |.||:     ||.|:     ||.|.|   ...|..:|....|...|.|             :
Human  1302 MQNPNYVH-----LPLSA-----AKNEELLSPGYSQFSLPVQKKVMSTPLS-------------K 1343

  Fly  1265 INGLLLADDIRKQVSADLGLGRQQIEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLK--DDTIN 1327
            .|.|.....|||                              |:||....||:|.:|:  .:.:|
Human  1344 SNTLNSFSKIRK------------------------------EILKTPDSSKEKVNLQRFKEALN 1378

  Fly  1328 GK-DLAD--VEKKPTS------------EETQL--DKDSKDDKVEKSAIE------LIIEGEEKL 1369
            .. |.::  :||..:|            |:.||  ..:|:||::.:..::      |....::|.
Human  1379 STFDYSEFSLEKSKSSGPMYLHKSCHSVEDGQLLTSNESEDDEIFRRKVKRAKGNVLNSPEDQKN 1443

  Fly  1370 QEADDFIEIGTWSNDMADDIASFNQEDDDEDDAFHLPVLPANVKFCDQQTRYGSPTFWDVSNGES 1434
            .|.|..:..........:.::.:..|....|::.:.|      |.|.|...:      .|.||.:
Human  1444 SEVDSPLHAVKKRRFPINRVSKYQSELSSSDESENFP------KPCSQLEDF------KVCNGNA 1496

  Fly  1435 --GFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHHNYSSDDDDVA 1497
              |.|.||...:                                     |.::...:..|:.:::
Human  1497 RRGIKVPKRQSH-------------------------------------LKHVARKFLDDEAELS 1524

  Fly  1498 DDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEP 1562
            :: ||..::....:|:|..:.:..::....:..:.||.|.:|.:....|:|           :.|
Human  1525 EE-DAEYVSSDENDESENEQDSSLLDFLNDETQLSQAINDSEMRAIYMKSL-----------RSP 1577

  Fly  1563 ATIRYEESIAKLKTEIESGGMLVPHDQQLVLKRS---DAAEAQVAKVSMMELLKQLLPYVNEDVL 1624
            ......:.|.|....|..... :|...:..|:.|   |..|:...:.|..|:... ...:.:|..
Human  1578 MMNNKYKMIHKTHKNINIFSQ-IPEQDETYLEDSFCVDEEESCKGQSSEEEVCVD-FNLITDDCF 1640

  Fly  1625 A--KKLGDRRELLLSDLVELNADWVARHEQETYNVMGCGDSFDNYNDHHRLNLDEKQLKLQYERI 1687
            |  ||...||.::|.:::|.|.   |..:::...::...||.:..|     |:::|    :...|
Human  1641 ANSKKYKTRRAVMLKEMMEQNC---AHSKKKLSRIILPDDSSEEEN-----NVNDK----RESNI 1693

  Fly  1688 EIEPPTSTK------AITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTMSNANDGIN 1740
            .:.|.|..|      .:.|  :|:|.|  .|..:...|..:|.......|..|..|.|:
Human  1694 AVNPSTVKKNKQQDHCLNS--VPSGSS--AQSKVRSTPRVNPLAKQSKQTSLNLKDTIS 1748

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dcr-1NP_524453.1 DEAD-like_helicase_N 15..208 CDD:421690 46/211 (22%)
Dicer_PBD 240..344 CDD:277191 18/116 (16%)
DEAD-like_helicase_C 490..614 CDD:365791 27/123 (22%)
Dicer_dimer 825..916 CDD:397444 23/113 (20%)
PAZ_dicer_like 1091..1212 CDD:239209 34/163 (21%)
RIBOc 1724..1930 CDD:238333 4/17 (24%)
RIBOc 2008..2172 CDD:238333
DSRM_DICER 2177..2240 CDD:380680
FANCMXP_011535336.1 MPH1 83..617 CDD:224036 126/666 (19%)
DEXDc 106..248 CDD:238005 36/169 (21%)
FANCM_ID 298..413 CDD:277190 21/146 (14%)
HELICc 439..589 CDD:238034 40/220 (18%)
FANCM-MHF_bd 675..789 CDD:293388 15/113 (13%)
MRC1 1513..>1593 CDD:286523 14/91 (15%)
ERCC4 1846..1953 CDD:280828
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R301
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.030

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