DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and drosha

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_001103942.1	Gene:	drosha / 567505	ZFINID:	ZDB-GENE-070209-23	Length:	1289	Species:	Danio rerio

Alignment Length:	789	Identity:	169/789 - (21%)
Similarity:	273/789 - (34%)	Gaps:	284/789 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly  1521 EVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYE---------ESIAKLKT 1576
            ::::.|...|:|            |..:::.|..:      ||.:.|.         :|..||:.
Zfish   676 QLDREQFNSSVI------------TFPIIVHFGIR------PAQLSYAGDPQYQKLWKSYVKLRH 722

  Fly  1577 EIESGGMLVPHDQQLVLKRSDAAEAQVAKVSM-----MELLKQ----------------LLPYVN 1620
            .:.:...:...|:|.:::|.:|.:....|.:|     :||..|                :||.:.
Zfish   723 LLANSPKVKQIDKQKLMQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLT 787

  Fly  1621 EDV--------LAKKLGDR-RELLLSDLV------ELNADWVARHEQETYNVMGCGDSFDNYND- 1669
            ..:        |.|.:|.. :|..|..|.      .||......|.:.  ::..||.....|.|
Zfish   788 HHIRYHQCLMHLDKLIGYMFKERCLLQLAMTHPSHHLNFGMNPDHARN--SLSNCGIRQPKYGDR 850

  Fly  1670 --HHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTM 1732
              ||           .|.|        .|.|.:.|        .....:|...||||.|
Zfish   851 KVHH-----------MYMR--------KKGINTLI--------NIMSRLGQDDPSPSRI------ 882

  Fly  1733 SNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEY 1797
             |.|     ||||.:||:.:::..:.:||..:.::.||.|:..|:..|.|.:|           .
Zfish   883 -NHN-----ERLEFLGDAVVEFLTSVHLYHLFPSLEEGGLATYRTAIVQNQHL-----------A 930

  Fly  1798 MIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALG 1862
            |:|.|.               ||::.::.|..|
Zfish   931 MLAKKL---------------ELDRFMLYAHGP-------------------------------- 948

  Fly  1863 LEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPR------ 1921
                            |.|.:...        :|     ::|:|.||||||..:|.|..
Zfish   949 ----------------DLCRESDL--------RH-----AMANCFEALIGAVYLEGGLEEAKDLF 984

  Fly  1922 GALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEEL 1986
            |.|||                              |.|::..|:..:|.  .||....|....:|
Zfish   985 GRLLF------------------------------NTEDMREVWLNYPP--HPLQVQEPLTDRQL 1017

  Fly  1987 ---DQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCY-QRLEFLGDAVLDYLITRHL 2047
               ..:|.....||:::|..|.....|.:|.|..:...|.||..: ||:|||||:::..:.|.:|
Zfish  1018 IESSPVLQKLTNFEDAIGVLFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYL 1082

  Fly  2048 YEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISE 2112
            :.....|..|.||.|||:||||...|.:|...|..:|     ...||...|.|.::
Zfish  1083 FIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEF-----AITNDKTKRPVALR--------- 1133

  Fly  2113 EYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNM-MSPEIEQF----S 2172
                              .|.|.|:.||...|:::|.:  |:.| |.:.|: ..|.:::|    .
Zfish  1134 ------------------TKTLADLLESFIAALYIDKD--LEFV-HTFMNVCFFPRLKEFILNQD 1177

  Fly  2173 NSVPKSPIRE-LLEL-----EPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRI--AKC 2229
            .:.|||.::: .|.|     ||:...:...:.:........||.|:.||...|.|:...|  |:.
Zfish  1178 WNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEM 1242

  Fly  2230 TAAKCALRQ 2238
            .||..||.:
Zfish  1243 GAAMDALEK 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690
		Dicer_PBD	240..344	CDD:277191
		DEAD-like_helicase_C	490..614	CDD:365791
		Dicer_dimer	825..916	CDD:397444
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333	43/211 (20%)
		RIBOc	2008..2172	CDD:238333	47/169 (28%)
		DSRM_DICER	2177..2240	CDD:380680	19/70 (27%)
drosha	NP_001103942.1	WWbp	<14..63	CDD:304964
		DUF1777	204..>320	CDD:285811
		PRP38_assoc	206..308	CDD:289628
		RIBOc	877..989	CDD:238333	44/210 (21%)
		rnc	1025..1253	CDD:234633	71/262 (27%)
		RIBOc	1042..1174	CDD:238333	47/166 (28%)
		DSRM	1181..1252	CDD:214634	20/71 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0571
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810