Protein Alignment Dcr-1 and drosha

DIOPT Version :10

• Sequence 1: NP_524453.1
• Gene: Dcr-1 / 42693
• FlyBaseID: FBgn0039016
• Length: 2249
• Species: Drosophila melanogaster
• Sequence 2: NP_001103942.1
• Gene: drosha / 567505
• ZFINID: ZDB-GENE-070209-23
• Length: 1289
• Species: Danio rerio
• Alignment Length: 789
• Identity: 169/789 - (21%)
• Similarity: 273/789 - (34%)
• Gaps: 284/789 - (35%)

  Fly  1521 EVEKRQKQLSIIQATNANERQYQQTKNLLIGFNFKHEDQKEPATIRYE---------ESIAKLKT 1576
            ::::.|...|:|            |..:::.|..:      ||.:.|.         :|..||:.
Zfish   676 QLDREQFNSSVI------------TFPIIVHFGIR------PAQLSYAGDPQYQKLWKSYVKLRH 722

  Fly  1577 EIESGGMLVPHDQQLVLKRSDAAEAQVAKVSM-----MELLKQ----------------LLPYVN 1620
            .:.:...:...|:|.:::|.:|.:....|.:|     :||..|                :||.:.
Zfish   723 LLANSPKVKQIDKQKLMQREEALQKIRQKNTMRREVTVELSSQGFWKTGIRSDVCQHAMMLPVLT 787

  Fly  1621 EDV--------LAKKLGDR-RELLLSDLV------ELNADWVARHEQETYNVMGCGDSFDNYND- 1669
            ..:        |.|.:|.. :|..|..|.      .||......|.:.  ::..||.....|.|
Zfish   788 HHIRYHQCLMHLDKLIGYMFKERCLLQLAMTHPSHHLNFGMNPDHARN--SLSNCGIRQPKYGDR 850

  Fly  1670 --HHRLNLDEKQLKLQYERIEIEPPTSTKAITSAILPAGFSFDRQPDLVGHPGPSPSIILQALTM 1732
              ||           .|.|        .|.|.:.|        .....:|...||||.|
Zfish   851 KVHH-----------MYMR--------KKGINTLI--------NIMSRLGQDDPSPSRI------ 882

  Fly  1733 SNANDGINLERLETIGDSFLKYAITTYLYITYENVHEGKLSHLRSKQVANLNLYRLGRRKRLGEY 1797
             |.|     ||||.:||:.:::..:.:||..:.::.||.|:..|:..|.|.:|           .
Zfish   883 -NHN-----ERLEFLGDAVVEFLTSVHLYHLFPSLEEGGLATYRTAIVQNQHL-----------A 930

  Fly  1798 MIATKFEPHDNWLPPCYYVPKELEKALIEAKIPTHHWKLADLLDIKNLSSVQICEMVREKADALG 1862
            |:|.|.               ||::.::.|..|
Zfish   931 MLAKKL---------------ELDRFMLYAHGP-------------------------------- 948

  Fly  1863 LEQNGGAQNGQLDDSNDSCNDFSCFIPYNLVSQHSIPDKSIADCVEALIGAYLIECGPR------ 1921
                            |.|.:...        :|     ::|:|.||||||..:|.|..
Zfish   949 ----------------DLCRESDL--------RH-----AMANCFEALIGAVYLEGGLEEAKDLF 984

  Fly  1922 GALLFMAWLGVRVLPITRQLDGGNQEQRIPGSTKPNAENVVTVYGAWPTPRSPLLHFAPNATEEL 1986
            |.|||                              |.|::..|:..:|.  .||....|....:|
Zfish   985 GRLLF------------------------------NTEDMREVWLNYPP--HPLQVQEPLTDRQL 1017

  Fly  1987 ---DQLLSGFEEFEESLGYKFRDRSYLLQAMTHASYTPNRLTDCY-QRLEFLGDAVLDYLITRHL 2047
               ..:|.....||:::|..|.....|.:|.|..:...|.||..: ||:|||||:::..:.|.:|
Zfish  1018 IESSPVLQKLTNFEDAIGVLFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEYL 1082

  Fly  2048 YEDPRQHSPGALTDLRSALVNNTIFASLAVRHGFHKFFRHLSPGLNDVIDRFVRIQQENGHCISE 2112
            :.....|..|.||.|||:||||...|.:|...|..:|     ...||...|.|.::
Zfish  1083 FIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEF-----AITNDKTKRPVALR--------- 1133

  Fly  2113 EYYLLSEEECDDAEDVEVPKALGDVFESIAGAIFLDSNMSLDVVWHVYSNM-MSPEIEQF----S 2172
                              .|.|.|:.||...|:::|.:  |:.| |.:.|: ..|.:::|    .
Zfish  1134 ------------------TKTLADLLESFIAALYIDKD--LEFV-HTFMNVCFFPRLKEFILNQD 1177

  Fly  2173 NSVPKSPIRE-LLEL-----EPETAKFGKPEKLADGRRVRVTVDVFCKGTFRGIGRNYRI--AKC 2229
            .:.|||.::: .|.|     ||:...:...:.:........||.|:.||...|.|:...|  |:.
Zfish  1178 WNDPKSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGCGKGPSIQQAEM 1242

  Fly  2230 TAAKCALRQ 2238
            .||..||.:
Zfish  1243 GAAMDALEK 1251

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:475120
		Dicer_PBD	240..344	CDD:277191
		P-loop containing Nucleoside Triphosphate Hydrolases	490..614	CDD:476819
		Dicer_dimer	825..916	CDD:460900
		PAZ_dicer_like	1091..1212	CDD:239209
		RIBOc	1724..1930	CDD:238333	43/211 (20%)
		RIBOc	2008..2172	CDD:238333	47/169 (28%)
		DSRM_DICER	2177..2240	CDD:380680	19/70 (27%)
drosha	NP_001103942.1	SF-CC1	213..>369	CDD:273721
		RIBOc	877..989	CDD:238333	44/210 (21%)
		Rnc	1025..1253	CDD:440336	71/262 (27%)