DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dcr-1 and Fancm

DIOPT Version :9

Sequence 1:	NP_524453.1	Gene:	Dcr-1 / 42693	FlyBaseID:	FBgn0039016	Length:	2249	Species:	Drosophila melanogaster
Sequence 2:	NP_001262806.1	Gene:	Fancm / 42543	FlyBaseID:	FBgn0038889	Length:	1489	Species:	Drosophila melanogaster

Alignment Length:	1813	Identity:	327/1813 - (18%)
Similarity:	548/1813 - (30%)	Gaps:	666/1813 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NNLHTTVFTPRDFQVELLATAYERNTIICLGHRSSKEFIALKLLQELSRRARRHGRVSVYLSCEV 72
            |||..     |.:|..::.:|..:||::.|.....|.|||..::....|
  Fly    54 NNLPL-----RSYQQTIVQSALFKNTLVVLPTGLGKTFIAAVVMYNFYR---------------- 97

  Fly    73 GTSTEPCSIYTMLTHLTDLRVWQEQPDMQIPFDHCWTDYHVSILRPEG-FLYLLETRELLLSSVE 136
                                 |.                      |:| .:::..||.|
  Fly    98 ---------------------WY----------------------PKGKIVFMAPTRPL------ 113

  Fly   137 LIVLEDCHDSAVYQRIRPLFENHIMPAPPADRPRILG-LAGPLHSAGCELQQLSAMLATLEQSVL 200
              |.:..|.|           ..|||.|..|..::.| |..|..:   ||.....:.....|.|
  Fly   114 --VSQQIHAS-----------QKIMPFPSEDTVQLTGQLPRPKRA---ELWASKRVFFATPQVV- 161

  Fly   201 CQIETASDIVTVLRYCSRPHEYIVQCAPFEMDELSLVLADVLNTHKSFLLDHRYDPYEIYGTDQF 265
                 .||::.....||           |....:.|::.|..:..|.     ||...::  .|..
  Fly   162 -----HSDMLEADGECS-----------FPFGSIKLIVVDEAHRAKG-----RYAYTQV--ADCL 203

  Fly   266 MDE--------LKDIPDPKVDPLNVINSLLVVLHEMGPWCT--------QRAAHHFYQCNEKLKV 314
            |..        |...|...::.:..:...|.:.:....|.|        .|........:.|.::
  Fly   204 MARNRYFRMLALSATPGRTMEDVAAVCRNLYISNLQVRWDTSIDVQPYIHRRTIRTIVVSLKERI 268

  Fly   315 KTPHERHYLLYCLVSTALIQLYSLCEHAFHRHLGSGSDSRQTIERYSSPKVRRLLQTLRCFKPEE 379
            |.|.||   |..::...|.||       ....:..|  ::.|:.|.|      ||...:.|
  Fly   269 KEPRER---LLQIIEPYLRQL-------MEAEIFKG--NKGTVSRNS------LLFEQKSF---- 311

  Fly   380 VHTQADGLRRMRHQVDQADFN---RLSHTLESKCR-----MVDQMDQPPTETRALVAT------- 429
            |...|.|.|...|.:...:|.   .:.|:|:...|     .|:..|.........|..
  Fly   312 VERSAQGQRHPDHNIIMGNFAMCISMYHSLDLMERHGLRVFVNNFDADDDGREKFVLARDGNLRN 376

  Fly   430 -LEQI--------LHTTEDRQTNRSAARVTPTPTP---AHAKPKPSSGANTAQPRTRRRVYTRRH 482
             :||:        |..|....||   ..|.|.|:.   .|||.:            :.|....:|
  Fly   377 LVEQVRQELGANPLDYTTHAMTN---GEVPPLPSDLDFGHAKYE------------KLRQVLVQH 426

  Fly   483 HRDHNDGSDTLCALIYCNQNHTARVLFELLAEISRRDPDLKFLRCQYTTDRVADPTTEPKEAELE 547
            .:.:.|..    |:::|....:..::..||.:   ..|.|: .||     .|...:|......|.
  Fly   427 FQANPDSR----AIVFCEYRESVMLIHRLLLQ---HRPVLR-PRC-----FVGQGSTVGASYALT 478

  Fly   548 HRRQEEVLKRFRMHDCNVLIGTSVLEEGIDVPKCNLVVRWD----PPTTYRSYVQCKGRARAAPA 608
            .::|.:::..||....|||:.||:.|||:||.:..::|.:|    .||.:...:...||.:....
  Fly   479 QKQQLQIMTDFRSGTSNVLVATSIGEEGLDVGEVEMIVCFDICSTNPTRFIQRIGRTGRKKNGEV 543

  Fly   609 YHVILVAPSYKSPTVGSVQLTDRSHRYICATGDTTEADSDSDDSAMPNSSGSDPYTFGTARGTVK 673
              |:||....:...:..|.                 |:.|..:..:.|||            .||
  Fly   544 --VMLVTEGREQQVLKDVL-----------------ANKDQINKKLLNSS------------VVK 577

  Fly   674 I----LNPEVFSKQPPTACDIK-LQEIQDELP---AAAQLDTSNSSDEAVSMS--------NTSP 722
            :    .||.:...:....|:.| ::.:.:|.|   :||:...|....:.|:.:        .:.|
  Fly   578 LSLYEQNPRMVPSKFQPKCEEKHMEPVAEEKPKPKSAAKTKESRKRKQPVAQTGSLRKYFKESPP 642

  Fly   723 SESS-------------------TEQKSRRFQCELSSLTEPEDTSDT--------------TAEI 754
            :||.                   .:|:..|....|.:.......|.|              |..:
  Fly   643 TESQQGILQGIKPYQMSEASQQLVKQQVLRRSVTLKNFFGESQASSTLTSSQEDVQRLRKLTRLL 707

  Fly   755 DTAHSLASTTKDLVHQMAQ---YREIEQMLLSKCANTEPPEQEQSEAERFSACLAAYRPKPHLLT 816
            .::....|.:|||:..:..   .|:|:..||.  :|.|                  :..:.||..
  Fly   708 QSSKPFVSDSKDLMSHLQDDHLPRQIKLYLLK--SNPE------------------FLRETHLKM 752

  Fly   817 GASVDLGSAIALVN------KYCARLPSDTFTKLTALWRCTRNERAGVTL-FQYTLRLPI--NSP 872
            ....:|..|...:|      |...:|..|....:..:....:.:.:|..: |:..|. ||  .||
  Fly   753 QVQSELNIADDRLNSRQRRTKNNYQLLLDICDGMDQMNELLQGDNSGAEISFRDELN-PIYNQSP 816

  Fly   873 LKHDIV-----------GLPMPT----QTLARRLAALQACVELHRIGELDDQLQPIGKEGFRALE 922
            .|.|.:           ||....    |.|..:|       ||.       .|:....|....:|
  Fly   817 KKFDTICEQIFDGLNEHGLNSNNFELKQDLLEKL-------ELR-------NLETTVNEQLGGIE 867

  Fly   923 PDWECFELEPEDEQI----VQLSDE---------PRPGTTKR-----------------RQYYYK 957
            ..|...|.:.::|.:    :.||.:         |...|..|                 .:|:..
  Fly   868 ASWSEEEWDQQEEDVKFESMYLSQQLNLPDANVVPHSSTPLRVKPLSKLMFKTLQGDIEEEYHSG 932

  Fly   958 RIASEFCD------------------CRPVAGAPCYLYFIQLTLQCPIPEEQNTRGRKIYPP-ED 1003
            ..|||..|                  ...:|               |||...:|.....:|. |:
  Fly   933 MEASELGDNLGRLNSLMNASESKIKATERIA---------------PIPVVDSTIETNHFPAVEE 982

  Fly  1004 AQQGFGI-----------LTTKRIPKLSAFSIFTRSGEVKVSLELAKERVILTSEQIVCINGFLN 1057
            :|:...|           ....:..::...||.....|||.||.|......:..:..:.::.||
  Fly   983 SQRSTPISIADSSGESNHCAVNKNSEIYPMSIDETKVEVKSSLNLKMHAESIVEDLDIDLDDFL- 1046

  Fly  1058 YTFTNVLRLQKFLMLFDPDSTENCVFIVPTVKAPAGGKHIDWQFLELI-QANGNTMPRAVPDEER 1121
                            :|...|                      |||. |..|.:....|..:..
  Fly  1047 ----------------EPMDKE----------------------LELASQTKGKSQENIVDHQME 1073

  Fly  1122 QAQPFDPQRFQDAVVMPWYRNQDQPQYFYVAEICPHLSPLSCFPGDNYRTFKHYYLVKYGLTIQN 1186
            :.:                :|.:|.:       ..|.:.|. ...::.:.|....:.:..|..|.
  Fly  1074 KLE----------------KNCEQKE-------TAHNNDLD-LTDEDLKEFLEPMVEEVELMSQK 1114

  Fly  1187 TSQPLLDVDHTSARLNFLTP-------RYVNRKGVALPTSSEETKRAKRENLEQ--KQILVPE-- 1240
            .:....|         ||.|       ....:|.:.|| |:|..|.::.:|..:  .:.:.|:
  Fly  1115 KANDFKD---------FLEPMPEELELMSQQKKNILLP-STETIKNSENKNSHEDGSRTVSPDIF 1169

  Fly  1241 ----LCTVHPFPASL------WRTAVCLPCILYRINGLLLADDIRKQVSA----------DLGLG 1285
                :..:.|...||      ...|..|||......||...:: ||:.:.          ||.|.
  Fly  1170 GSDSMSPLKPQGKSLAAKLAAKAAAKVLPCPPPNSVGLNSPEN-RKRTNPSIQEKSPSIFDLYLN 1233

  Fly  1286 RQQ-------------------------IEDEDFEWPMLDFGWSLSEVLKKSRESKQKESLKDDT 1325
            |.:                         .::||            |.:.:  |.||:|..:..|
  Fly  1234 RMRGRGRLAKAAENLHRITSTNPTISVPKDEED------------SPIAR--RPSKRKIVISSD- 1283

  Fly  1326 INGKDLADVEKKPTSEETQLDKDSKD-------------------------------DKVEKSAI 1359
                  .:.|:||...|||:|.:|.|                               |:.|||..
  Fly  1284 ------EEEEQKPQIAETQVDCESDDYERILDTQMPDPRKTPTRPRHKRSKFNSFILDEAEKSGS 1342

  Fly  1360 ELIIEGEEKLQEADDFIEIGTWSNDMADDIASFNQED--DDEDDAFHLPVLPANVKFCDQQTRYG 1422
            :...|||         ..|||:..|..  |.|.:.||  |....|.:|..|.:.::      |.|
  Fly  1343 DHEEEGE---------TTIGTYLKDSM--IVSSDDEDHNDTNTHAIYLRALKSPIQ------RPG 1390

  Fly  1423 SPTFWDVSNGESGFKGPKSSQNKQGGKGKAKGPAKPTFNYYDSDNSLGSSYDDDDNAGPLNYMHH 1487
            :            ||.|                  |...:.|..:......:||.:    .||..
  Fly  1391 A------------FKMP------------------PPRVFRDESHIFSQPVEDDSS----QYMQC 1421

  Fly  1488 NYSSDDDDVADDIDAGRIAFTSKNEAETIETAQEVEKRQKQLSIIQATNANERQYQQT 1545
            ::..||:  :..|:.|.  ..|:...|..|...:..::|::|..:.:...|:|:..||
  Fly  1422 SFIVDDE--SSTIERGH--DVSECPLEKAERILKERRKQRRLGKVPSAPVNKRRRLQT 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dcr-1	NP_524453.1	DEAD-like_helicase_N	15..208	CDD:421690	32/194 (16%)
		Dicer_PBD	240..344	CDD:277191	21/119 (18%)
		DEAD-like_helicase_C	490..614	CDD:365791	31/127 (24%)
		Dicer_dimer	825..916	CDD:397444	22/114 (19%)
		PAZ_dicer_like	1091..1212	CDD:239209	17/128 (13%)
		RIBOc	1724..1930	CDD:238333
		RIBOc	2008..2172	CDD:238333
		DSRM_DICER	2177..2240	CDD:380680
Fancm	NP_001262806.1	MPH1	43..608	CDD:224036	141/744 (19%)
		ResIII	55..221	CDD:282678	48/275 (17%)
		FANCM_ID	269..378	CDD:277190	27/130 (21%)
		Helicase_C	417..539	CDD:278689	33/146 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R301
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.030